Publication

Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease

American Journal of Physiology-Renal Physiology 321(2):F149-F161, 2021

Østergaard MV, Secher T, Christensen M, Salinas CG, Roostalu U, Skytte JL, Rune I, Hansen HH, Jelsing J, Vrang N, Fink LN

Subjects
3D imagingdb/db mouseTherapeutic AreaAdeno-associated virus (AAV)-mediated gene deliveryReninAAV UNx db/db mouseTargetMouseChronic kidney disease (CKD)CompoundMethod/EndpointSpeciesAngiotensin converting enzyme (ACE)Body weightBlood biochemistryDiabetic kidney disease (DKD)EmpagliflozinGlomerular filtration rate (GFR)Histopathology scoreImage analysisImmunohistochemistryKidney morphometryLight sheet fluorescence microscopy (LSFM)NephrectomySGLT-2LisinoprilSurgeryUrine biochemistry

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