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PRECLINICAL Cro services in

Liver (MASH)

Gubra is industry-leading in translational models of metabolic dysfunction-associated steatohepatitis (MASH) and MASH-driven hepatocellular carcinoma (MASH-HCC). Our automated AI-based histology pipeline enables effective, accurate and objective analysis of drug effects on pivotal clinical endpoints.

Why choose Gubra?
  • Expert scientific guidance in MASH
  • Clinically translatable models
  • GAN DIO-MASH mouse ranked #1 by LITMUS consortium
  • Biopsy-enabled stratification of baseline disease
  • Profile compounds using clinical trial endpoints
  • Tailored study design and rapid initiation
mash models
mash models

Consult with Michael Feigh

Vice President, Scientific Sales

Choose the right animal model for your MASH-targeted drug candidate.

What is MASH?

Metabolic Dysfunction-associated Steatohepatitis (MASH)

Metabolic dysfunction-associated steatohepatitis (MASH) and metabolic dysfunction-associated steatotic liver disease (MASLD), respectively, are now the replacement terms for non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD).

Industry-leading models for translatability into the clinic


Choosing the right translational model of MASH is crucial for efficacy evaluation and bridging to clinical development. Our GAN DIO-MASH mouse model has been ranked #1 by the LITMUS consortium for its human proximity score and clinical translatability. Our model is already induced and ready to be used for your study. With reference to standard clinical practice, all animals are biopsy-confirmed for stratification of baseline disease which allows for within-subject evaluation of histological outcomes.

Main Offerings

mash models

Full metabolic assessment

mash models

Biochemical assessment liver & plasma

mash models

NAS & fibrosis scoring (pre-post)

mash models

Quantitative histology Steatohepatitis & fibrosis

mash models

Hepatic transcriptomic profile

mash models

GAN DIO-MASH mice readily available

High clinical translatability

Models of MASH

Cloud-based data viewer

GubraView

Our cloud-based data viewer GubraView provides instant access to study data as it is uploaded, ensuring seamless monitoring throughout your study. With features for cross-group and cross-study comparisons, GubraView enables informed decision-making with statistical analyses. Accessible across multiple locations, GubraView empowers efficient and collaborative drug development for your whole team.

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Close-up of 3D light sheet imaged mouse brain following anti-obesity drug treatment

Related pages

For further information

Contact us

Gubra

Hørsholm Kongevej 11B
2970 Hørsholm
Denmark

+45 3152 ­2650

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