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PRECLINICAL Cro services in

Liver (MASH)

Gubra is industry-leading in translational models of metabolic dysfunction-associated steatohepatitis (MASH) and MASH-driven hepatocellular carcinoma (MASH-HCC). Our automated AI-based histology pipeline enables effective, accurate and objective analysis of drug effects on pivotal clinical endpoints.

Why choose Gubra?
  • Expert scientific guidance in MASH
  • Clinically translatable models
  • GAN DIO-MASH mouse ranked #1 by LITMUS consortium
  • Biopsy-enabled stratification of baseline disease
  • Profile compounds using clinical trial endpoints
  • Tailored study design and rapid initiation

Consult with Michael Feigh

Vice President, Scientific Sales

Choose the right animal model for your MASH-targeted drug candidate.

What is MASH?

Metabolic Dysfunction-associated Steatohepatitis (MASH)

Metabolic dysfunction-associated steatohepatitis (MASH) and metabolic dysfunction-associated steatotic liver disease (MASLD), respectively, are now the replacement terms for non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD).

Industry-leading models for translatability into the clinic


Choosing the right translational model of MASH is crucial for efficacy evaluation and bridging to clinical development. Our GAN DIO-MASH mouse model has been ranked #1 by the LITMUS consortium for its human proximity score and clinical translatability. Our model is already induced and ready to be used for your study. With reference to standard clinical practice, all animals are biopsy-confirmed for stratification of baseline disease which allows for within-subject evaluation of histological outcomes.

Main Offerings

Full metabolic
assessment

Biochemical assessment
liver & plasma

NAS & fibrosis scoring
(pre-post)

Quantitative histology
Steatohepatitis & fibrosis

Hepatic transcriptomic
profile

GAN DIO-MASH
mice
readily available

High clinical translatability

Models of MASH & MASH-HCC

Related pages

For further information

Contact us

Gubra

Hørsholm Kongevej 11B
2970 Hørsholm
Denmark

+45 3152 ­2650

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