Cro services in

Obesity

At Gubra we have extensive scientific expertise and capabilities to conduct preclinical studies using animal models of obesity. We conduct comprehensive efficacy and mode-of-action studies combining in vivo metabolic profiling with biomarker analysis, histology, whole-brain imaging and RNAseq to evaluate and visualize the effects of your drug candidate.

Why choose Gubra?

Expert scientific guidance within obesity
Extensive experience in anti-obesity drug profiling
Diet-induced obese (DIO) models readily available
Tailored study design and rapid initiation
Whole-brain 3D imaging of drug responses

Consult with Marco Tozzi

Senior Scientist, Scientific Sales

Advance your obesity drug development with our extensive knowhow.

Choose an experienced partner in anti-obesity drug profiling

Our scientific and technical expertise in the obesity field has enabled us to profile several approved anti-obesity drugs. The combination of Gubra’s extensive knowhow and availability of rodent models guarantees speedy delivery of solid and comprehensive data.

Main Offerings

DIO mice
readily available

Treatment efficacy studies

Real-time food
intake monitoring

Gastric emptying
studies

Taste aversion &
pica behavior

Energy expenditure testing

Accelerate your anti-obesity drug profiling

Models of obesity

DIO mouse

Model for obesity and metabolic syndrome
HFD-driven adiposity and prediabetes
Readily available at Gubra
Extensive in-house standard-of-care benchmarking
Suitable for monotherapy and combinatorial profiling

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DIO rat

Model for obesity and metabolic syndrome
HFD-driven adiposity and prediabetes
Readily available at Gubra
In-house standard-of-care benchmarking
Suitable for monotherapy and combinatorial profiling

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ob/ob mouse

Model for obesity and type II diabetes
Hyperphagia-driven overt obesity
Marked insulin resistance and glucose intolerance
Intact leptin receptor signaling
Suitable for monotherapy and combinatorial profiling

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Investigate your compound’s mode of action

Acute obesity studies

Real-time food intake/activity analysis

HM2 and PhenoMaster systems
Detailed real time acute food/water intake
Detailed real time locomotor activity
Suitable for lean or DIO mice/rats
Screening up to 14 compounds/doses

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Energy expenditure monitoring

TSE system
Detailed real time indirect calorimetry monitoring
Possibility to run studies at Thermoneutrality
Acute or semi-chronic studies
Suitable for lean or DIO mice/rats

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In-study and stand-alone tests

Food preference
Taste aversion and pica behavior
Gastric emptying
c-Fos activation 3D imaging
Brain receptor mapping

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Cloud-based BRAIN DATA VIEWER

Explore GubraView

GubraView visualizes your compound’s impact and enables fast and effective data mining for your specific brain regions of interest. See your compound’s neurological effects with your own eyes.

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Visualize your compound’s effects

3D Imaging
Video Gallery

Visualize the neurological impacts of your obesity drug candidate. Gubra uses modern whole-brain 3D imaging to provide deeper insight into neurochemical interactions.

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