Cro services in
Obesity
At Gubra we have extensive scientific expertise and capabilities to conduct preclinical studies using animal models of obesity. We conduct comprehensive efficacy and mode-of-action studies combining in vivo metabolic profiling with biomarker analysis, histology, whole-brain imaging and RNAseq to evaluate and visualize the effects of your drug candidate.
Why choose Gubra?
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Expert scientific guidance within obesity
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Extensive experience in anti-obesity drug profiling
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Diet-induced obese (DIO) models readily available
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Tailored study design and rapid initiation
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Whole-brain 3D imaging of drug responses


Consult with Marco Tozzi
Senior Scientist, Scientific Sales
Advance your obesity drug development with our extensive knowhow.
Choose an experienced partner in anti-obesity drug profiling
Our scientific and technical expertise in the obesity field has enabled us to profile several approved anti-obesity drugs. The combination of Gubra’s extensive knowhow and availability of rodent models guarantees speedy delivery of solid and comprehensive data.
Main Offerings
DIO mice
readily available
Treatment efficacy studies
Real-time food
intake monitoring
Gastric emptying
studies
Taste aversion &
pica behavior
Energy expenditure testing
Accelerate your anti-obesity drug profiling
Models of obesity

DIO mouse
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Model for obesity and metabolic syndrome
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HFD-driven adiposity and prediabetes
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Readily available at Gubra
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Extensive in-house standard-of-care benchmarking
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Suitable for monotherapy and combinatorial profiling

DIO rat
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Model for obesity and metabolic syndrome
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HFD-driven adiposity and prediabetes
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Readily available at Gubra
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In-house standard-of-care benchmarking
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Suitable for monotherapy and combinatorial profiling

ob/ob mouse
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Model for obesity and type II diabetes
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Hyperphagia-driven overt obesity
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Marked insulin resistance and glucose intolerance
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Intact leptin receptor signaling
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Suitable for monotherapy and combinatorial profiling
Investigate your compound’s mode of action
Acute obesity studies

Real-time food intake/activity analysis
- HM2 and PhenoMaster systems
- Detailed real time acute food/water intake
- Detailed real time locomotor activity
- Suitable for lean or DIO mice/rats
- Screening up to 14 compounds/doses

Energy expenditure monitoring
- TSE system
- Detailed real time indirect calorimetry monitoring
- Possibility to run studies at Thermoneutrality
- Acute or semi-chronic studies
- Suitable for lean or DIO mice/rats

In-study and stand-alone tests
- Food preference
- Taste aversion and pica behavior
- Gastric emptying
- c-Fos activation 3D imaging
- Brain receptor mapping

Related pages
For further information
Contact us
Gubra
Hørsholm Kongevej 11B
2970 Hørsholm
Denmark
+45 3152 2650