Technologies in

3D Imaging

Our light sheet microscopy and whole organ labelling are revolutionizing the understanding of disease progression and drug distribution. Gubra is industry-leading in whole organ imaging and AI-assisted quantification of histological markers. Our cutting-edge approach is shaping the future of 3D imaging in preclinical drug discovery.

Why Gubra?

Immunolabeling of disease endpoints
Whole organ ISH for receptor mapping
Visualization of viral or non-viral gene delivery
In vivo distribution of fluorescently labelled compounds
AI-assisted quantification of endpoints

Consult with Jacob Hecksher-Sørensen

Director, Scientific Sales

Find out how whole-organ 3D imaging can visualize and quantify drug effects.

Get the full picture
with whole organ imaging

We can apply quantitative 3D light sheet microscopy to any organs in the mouse and rat. Our imaging platform is integrated into Gubra’s pipeline and works seamlessly in combination with our animal models and in-house developed algorithms to ensure absolute quantification of disease endpoints.

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Main Offerings

Quantitative whole
organ imaging

Applicable to all organs

Segmentation of
complex 3D structures

Complete
pharmacological solutions

Multiplexed IHC &
ISH endpoints

In vivo distribution

Whole Organ Imaging Services

Kidney Diseases

Precise quantification of glomeruli
Determine changes in glomerular size
Monitor vascular changes

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Cardiovascular Diseases

Plaque burden in arteroschlerosis models
Cardiac fibrosis
Cardiac vascular network density
Ventricular volume

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Diabetes

Pancreatic islet/β-cell number and volume
Sympathetic innervation
Intra-islet Inflammation

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Gene Therapy

Visualize viral and non-viral gene delivery
Visualize and quantify gene expression or knock-down

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Vasculature

Vascular density
Branch points
Vascular length

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Customized Services

Ocular imaging
Adipose tissue
Spinal cord
Others

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Interpret complex organ effects

Explore Preclinical Endpoints in 3D

Pancreas

Functional Kidney

Liver Imaging

TH Neuron

Cloud-based brain data viewer

GubraView

Gubra offers an interactive cloud-based brain-viewer. Click on any brain region and get instant access to statistical information about cell counts and signal intensities. The platform facilitates easy access across multiple geographical sites.

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