Cro services in

CNS / Brain Imaging

Our imaging services provide a new innovative strategy for characterizing CNS disease models, mapping drug targets and evaluating treatment effects. We use fully automated light-sheet microscopy for 3D imaging of the intact brain at single cell resolution.

Why Gubra?

End-to-end light-sheet service provider
Fully automated immunolabeling and clearing
AI-assisted mapping and quantification
Cloud-based interactive brain data viewer
Approximately 2.5 months from study to data presentation

Consult with Jacob Hecksher-Sørensen

Director, Scientific Sales

Get expert advice on whole-brain imaging and discuss how to design your next study.

Imaging services that enable quantification and visualization of your drug’s effects

Gubra is changing the future of preclinical CNS drug discovery with an industry-leading 3D imaging platform. Explore how our whole-brain imaging pipeline can visualize drug distribution, map drug targets and quantify treatment outcomes in unprecedented detail.

Explore Now

Main Offerings

Quantitative
whole brain imaging

Anatomical
reference mapping

Automated
stereotactic surgery

Complete
pharmacological solutions

Multiplexed
IHC & ISH endpoints

Gene
& cell therapy

Complex 3D imaging data to clear interpretable data

Atlas-defined CNS imaging endpoints

Parkinson’s Disease

Quantification of total dopaminergic neuron numbers
Mapping and quantifying α-synuclein aggregate spreading Neuroinflammation markers
Markers of axon architecture
Monitoring progression of motor deficits

Learn more

Alzheimer’s Disease

Quantification of amyloid plaque burden
Mapping cerebral amyloid angiopathy
Visualization of drug distribution and BBB penetration
Neuronal loss and brain atrophy

Learn more

CNS activation

Whole-brain activation (c-Fos) maps
Voxel-based statistical maps for subanatomical responses
Comparative c-Fos maps for benchmarking drugs

Learn more

Drug distribution

Visualization and mapping of CNS drug distribution
Parenchyma vs vascular drug distribution
Mapping and quantifying BBB penetrance

Learn more

Gene therapy

Distribution of AAV and non-viral gene delivery systems
Visualization of siRNA distribution
Validation and quantification of target knockdown/overexpression

Learn more

Gene expression

Whole-brain in situ hybridization for gene expression maps
Quantification of drug target expression at single-nuclei resolution
Delineating gene expression changes in disease models

Learn more

Open-source Brain Map Database

Visit NeuroPedia

NeuroPedia is an open source database for digital whole-brain maps recorded using light-sheet microscopy. Researchers around the globe can access data from various experiments and overlay gene expression data with neuronal activity and connectivity.

Explore