Get solid data to base decisions on

Diabetes research services

Contract research services within diabetes

We have extensive experience conducting preclinical diabetes studies in a variety of different rodent models of both type I and type II diabetes. We have a long track record of creating impact for our customers, when it comes to working with difficult models like ZDF rats and db/db mice as well as quantitating beta-cell mass and other histological-pathological endpoints of diabetes.

Our scientific expertise within diabetes combined with our effective CRO experience results in solid data to base decisions on. Furthermore, we have a high animal availability, which enables us to accelerate studies.

We offer:

  • Extensive experience with the majority of commercially available rodent models (C57BL/6, ob/ob, db/db mice as well as SPD and ZDF rats)
  • Oral/intravenous/intraperitoneal glucose tolerance tests (OGTT, IVGTT, IPGTT) and insulin tolerance test (ITT)
  • Continuous (24h) glucose monitoring in rats
  • Insulin sensitivity testing (endogenous glucose production and tissue glucose uptake) using the hyperinsulinemic euglycemic clamp
  • NOD mice and models of pancreatectomy
  • Models of diabetic nephropathy and diabetic CVD
  • RNA sequencing and bioinformatics

Get in touch

Get in touch if you are interested in discussing how to get started with your study.

Niels Vrang

Co-founder, Chairman of the board
niels@gubra.dk
+45 3152 2651

Various type 2 diabetes rodent models

We have experience with several of all available models in the marked. Here you can get an overview of the phenotypical features of typical type 2 diabetes models at Gubra.

Overview of type II diabetes models  |  Check out our other models

Type 1 diabetes model (Gubra PX rat)

The Gubra pancreatectomized (PX) rat is hyperglycemic from the time of PX and is ideal for anti-diabetic pharmacological testing and for modeling diabetic complications.

Overview of type 1 diabetes model – Partial and complete pancreatectomy

db/db mouse model

When evaluating the potential proliferative effects of various interventions (pharmacological or non-pharmacological), our research has shown that the db/db mouse model is preferable.

Read article: Characterization of Age-Dependent Beta Cell Dynamics in the Male db/db Mice

ZDF rat model

Thorough knowledge of the ZDF rat model is a must if you want to optimize your study design in accordance with drug type and mode of action. Take a look at our film on the subject to learn more about how this model can be used.



“Gubra is a highly competent partner in execution of – also more complicated – preclinical studies. The long term experience and the deep scientific competence of Gubra partners adds value to the studies and is a guaranty for trustworthy results.“

Dr. Michael Mark
Vice President | Boehringer Ingelheim

Gubra

Hørsholm Kongevej 11B
2970 Hørsholm
Denmark

info@gubra.dk
+45 3152 ­2650