Contract research services within diabetes

We have extensive experience of conducting preclinical diabetes studies in a variety of different rodent models of both type 1 and type 2 diabetes. We have a long track record of creating impact for our customers, when it comes to working with difficult models such as ZDF rats and db/db mice as well as quantitating beta-cell mass and other histological-pathological endpoints of diabetes.

Our scientific expertise within diabetes, combined with our effective CRO experience, provide solid data on which to base decisions. Furthermore, we have a high availability of animal enabling us to accelerate studies.

Our main offerings:

• Extensive experience with the majority of commercially available rodent models (C57BL/6, ob/ob, db/db mice as well as SPD and ZDF rats)
• Oral/intravenous/intraperitoneal glucose tolerance tests (OGTT, IVGTT, IPGTT) and insulin tolerance test (ITT)
• Continuous (24h) glucose monitoring in rats
• Insulin sensitivity testing (endogenous glucose production and tissue glucose uptake) using the hyperinsulinemic euglycemic clamp
• NOD mice and models of pancreatectomy
• RNA sequencing and bioinformatics
• Glucose infusion study
• Hyperinsulinemic-euglycemic clamp