Get solid data to base decisions on

Diabetes research services

Contract research services within diabetes

We have extensive experience of conducting preclinical diabetes studies in a variety of different rodent models of both type 1 and type 2 diabetes. We have a long track record of creating impact for our customers, when it comes to working with difficult models such as ZDF rats and db/db mice as well as quantitating beta-cell mass and other histological-pathological endpoints of diabetes.

Our scientific expertise within diabetes, combined with our effective CRO experience, provide solid data on which to base decisions. Furthermore, we have a high availability of animal enabling us to accelerate studies.

Our main offerings:

  • Extensive experience with the majority of commercially available rodent models (C57BL/6, ob/ob, db/db mice as well as SPD and ZDF rats)
  • Oral/intravenous/intraperitoneal glucose tolerance tests (OGTT, IVGTT, IPGTT) and insulin tolerance test (ITT)
  • Continuous (24h) glucose monitoring in rats
  • Insulin sensitivity testing (endogenous glucose production and tissue glucose uptake) using the hyperinsulinemic euglycemic clamp
  • NOD mice and models of pancreatectomy
  • RNA sequencing and bioinformatics
  • Glucose infusion study
  • Hyperinsulinemic-euglycemic clamp

Get in touch

Please get in touch if you are interested in discussing how to get started with your study.

Niels Vrang

Co-founder, Chairman of the board
+45 3152 2651

Get in touch

Various type 2 diabetes rodent models

We have experience with several of the models available in the market. Here you can get an overview of the phenotypical features of typical type 2 diabetes models at Gubra.

Overview of type II diabetes models  |  Check out our methodologies

Type 1 diabetes model (Gubra PX rat)

The Gubra pancreatectomized (PX) rat is hyperglycemic from the time of PX and is ideal for anti-diabetic pharmacological testing and for modeling diabetic complications.

Overview of type 1 diabetes model – Partial and complete pancreatectomy

db/db mouse model

Our research has shown that the db/db mouse model is preferable for evaluating the potential proliferative effects of various interventions (pharmacological and non-pharmacological).

Read article: Characterization of Age-Dependent Beta Cell Dynamics in the Male db/db Mice

ZDF rat model

Thorough knowledge of the ZDF rat model is a must if you want to optimize your study design in accordance with drug type and mode of action. Take a look at our film on the subject to learn more about how this model can be used.
“Gubra is a highly competent partner in execution of – also more complicated – preclinical studies. The long term experience and the deep scientific competence of Gubra partners adds value to the studies and is a guaranty for trustworthy results.“

Dr. Michael Mark
Vice President | Boehringer Ingelheim

Type of studies

Mode of action studies

In a mode of action study we offer e.g.

  • Hyperinsulinemic euglycemic clamp studies
  • Lipogenesis
  • Lactate clamp
  • Gastric Bypass surgery
  • Energy expenditure
  • Insulin sensitivity testing (endogenous glucose production and tissue glucose uptake) using the hyperinsulinemic euglycemic clamp

Chronic efficacy studies

In a chronic efficacy study we offer e.g.

  • Long term effects on glucose homeostasis in ZDF rats
  • Chronic (7 days to 12+ weeks) efficacy testing
  • In-house developed and validated Glucose Compound pancreatectomy model
  • Ex vivo assays (insulin, HbA1c, glucose, GLP-1, PYY etc.)

Acute efficacy studies

In an acute efficacy study we offer e.g.

  • OGTT/IPGTT/IVGTT and ITT in rats and mice
  • Automatized food intake testing
  • In vitro biology

Main offerings


  • Metabolic assessment (body weight, adiposity, food intake, glycemic control and glucose tolerance)
  • Biochemical assessment for plasma lipids and liver biomarkers
  • Biochemical assessment for hepatic lipid, inflammation and collagen content
  • Histomorphomtric assesment for hepatic steatosis, inflammation, hepatocellular ballooning and fibrosis
  • Histopathological scoring for NAFLD Activity Score and Fibrosis Stage
  • Deep learning AI
  • RNA sequencing and bioinformatics
  • Flow cytometry