Contract research services within diabetes

We have extensive experience conducting preclinical diabetes studies in a variety of different rodent models of both type I and type II diabetes. We have a long track record of creating impact for our customers, when it comes to working with difficult models like ZDF rats and db/db mice as well as quantitating beta-cell mass and other histological-pathological endpoints of diabetes.

Our scientific expertise within diabetes combined with our effective CRO experience results in solid data to base decisions on. Furthermore, we have a high animal availability, which enables us to accelerate studies.

We offer:

Extensive experience with the majority of commercially available rodent models (C57BL/6, ob/ob, db/db mice as well as SPD and ZDF rats)
Oral/intravenous/intraperitoneal glucose tolerance tests (OGTT, IVGTT, IPGTT) and insulin tolerance test (ITT)
Continuous (24h) glucose monitoring in rats
Insulin sensitivity testing (endogenous glucose production and tissue glucose uptake) using the hyperinsulinemic euglycemic clamp
NOD mice and models of pancreatectomy
Models of diabetic nephropathy and diabetic CVD
RNA sequencing and bioinformatics

Get in touch

Get in touch if you are interested in discussing how to get started with your study.

Niels Vrang

Co-founder, Chairman of the board
niels@gubra.dk
+45 3152 2651

Book meeting

Various type 2 diabetes rodent models

We have experience with several of all available models in the marked. Here you can get an overview of the phenotypical features of typical type 2 diabetes models at Gubra.

Overview of type II diabetes models | Check out our other models

Type 1 diabetes model (Gubra PX rat)

The Gubra pancreatectomized (PX) rat is hyperglycemic from the time of PX and is ideal for anti-diabetic pharmacological testing and for modeling diabetic complications.

Overview of type 1 diabetes model – Partial and complete pancreatectomy

db/db mouse model

When evaluating the potential proliferative effects of various interventions (pharmacological or non-pharmacological), our research has shown that the db/db mouse model is preferable.

Read article: Characterization of Age-Dependent Beta Cell Dynamics in the Male db/db Mice

ZDF rat model

Thorough knowledge of the ZDF rat model is a must if you want to optimize your study design in accordance with drug type and mode of action. Take a look at our film on the subject to learn more about how this model can be used.

“Gubra is a highly competent partner in execution of – also more complicated – preclinical studies. The long term experience and the deep scientific competence of Gubra partners adds value to the studies and is a guaranty for trustworthy results.“

Dr. Michael Mark
Vice President | Boehringer Ingelheim

Type of studies

Mode of action studies

In a mode of action study we offer e.g.

Hyperinsulinemic euglycemic clamp studies
Lipogenesis
Lactate clamp
Gastric Bypass surgery
Energy expenditure
Insulin sensitivity testing (endogenous glucose production and tissue glucose uptake) using the hyperinsulinemic euglycemic clamp