Get solid data to base decisions on
Diabetes research services
Contract research services within diabetes
We have extensive experience of conducting preclinical diabetes studies in a variety of different rodent models of both type 1 and type 2 diabetes. We have a long track record of creating impact for our customers, when it comes to working with difficult models such as ZDF rats and db/db mice as well as quantitating beta-cell mass and other histological-pathological endpoints of diabetes.
Our scientific expertise within diabetes, combined with our effective CRO experience, provide solid data on which to base decisions. Furthermore, we have a high availability of animal enabling us to accelerate studies.
Our main offerings:
- Extensive experience with the majority of commercially available rodent models (C57BL/6, ob/ob, db/db mice as well as SPD and ZDF rats)
- Oral/intravenous/intraperitoneal glucose tolerance tests (OGTT, IVGTT, IPGTT) and insulin tolerance test (ITT)
- Continuous (24h) glucose monitoring in rats
- Insulin sensitivity testing (endogenous glucose production and tissue glucose uptake) using the hyperinsulinemic euglycemic clamp
- NOD mice and models of pancreatectomy
- RNA sequencing and bioinformatics
- Glucose infusion study
- Hyperinsulinemic-euglycemic clamp
Get in touch
Please get in touch if you are interested in discussing how to get started with your study.
Niels Vrang
Get in touch
Various type 2 diabetes rodent models
We have experience with several of the models available in the market. Here you can get an overview of the phenotypical features of typical type 2 diabetes models at Gubra.
Overview of type II diabetes models | Check out our methodologies
Type 1 diabetes model (Gubra PX rat)
The Gubra pancreatectomized (PX) rat is hyperglycemic from the time of PX and is ideal for anti-diabetic pharmacological testing and for modeling diabetic complications.
Overview of type 1 diabetes model – Partial and complete pancreatectomy
db/db mouse model
Our research has shown that the db/db mouse model is preferable for evaluating the potential proliferative effects of various interventions (pharmacological and non-pharmacological).
Read article: Characterization of Age-Dependent Beta Cell Dynamics in the Male db/db Mice
ZDF rat model
Thorough knowledge of the ZDF rat model is a must if you want to optimize your study design in accordance with drug type and mode of action. Take a look at our film on the subject to learn more about how this model can be used.
Type of studies
Mode of action studies
In a mode of action study we offer e.g.
- Hyperinsulinemic euglycemic clamp studies
- Lipogenesis
- Lactate clamp
- Gastric Bypass surgery
- Energy expenditure
- Insulin sensitivity testing (endogenous glucose production and tissue glucose uptake) using the hyperinsulinemic euglycemic clamp
Chronic efficacy studies
In a chronic efficacy study we offer e.g.
- Long term effects on glucose homeostasis in ZDF rats
- Chronic (7 days to 12+ weeks) efficacy testing
- In-house developed and validated Glucose Compound pancreatectomy model
- Ex vivo assays (insulin, HbA1c, glucose, GLP-1, PYY etc.)
Acute efficacy studies
In an acute efficacy study we offer e.g.
- OGTT/IPGTT/IVGTT and ITT in rats and mice
- Automatized food intake testing
- In vitro biology
Main offerings
- Metabolic assessment (body weight, adiposity, food intake, glycemic control and glucose tolerance)
- Biochemical assessment for plasma lipids and liver biomarkers
- Biochemical assessment for hepatic lipid, inflammation and collagen content
- Histomorphomtric assesment for hepatic steatosis, inflammation, hepatocellular ballooning and fibrosis
- Histopathological scoring for NAFLD Activity Score and Fibrosis Stage
- Deep learning AI
- RNA sequencing and bioinformatics
- Flow cytometry
