Cro services in
Kidney (CKD/DKD/AKI)
We offer a wide range of high-end preclinical models of kidney disease for profiling drug effects in chronic kidney disease (CKD), diabetic kidney disease (DKD) and acute kidney injury (AKI).
Why Gubra?
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Expert scientific guidance within kidney diseases
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Wide range of translational models
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Tailored study design and rapid initiation
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AI-assisted quantification of endpoints
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Combination of pharmacology, histology and 3D imaging
Consult with Michael Christensen
Principal Scientist, Scientific Sales
Get expert advice on choosing the right model for your project.
Explore our broad portfolio of preclinical kidney disease models
We offer advanced rodent models of kidney diseases to which we apply sophisticated surgeries, toxins or AAV-based techniques to accelerate kidney disease progression. We apply clinical endpoints to enhance model translatability.
Main Offerings
Kidney function assessment
Quantitative
fibrosis scoring
Quantitative
whole kidney imaging
Plasma & urine markers assessment
AI-assisted glomerulosclerosis scoring
Surgical expertise
& know-how
Profile your preclinical drug candidate
Diabetic Kidney Disease (DKD) Models
ReninAAV UNx db/db
- Hypertension-accelerated DKD
- Progressive albuminuria and glomerulosclerosis
- AI-assisted glomerulosclerosis scoring
- Standard-of-care (SoC) benchmarking
- Suitable for monotherapy profiling and in combination with SoC
ZSF-1 rat
- Genetic model of DKD
- Metabolic syndrome
- Progressive albuminuria and glomerulosclerosis
- AI-assisted glomerulosclerosis scoring
- Standard-of-care benchmarking
- Suitable for monotherapy profiling and in combination with SoC
Profile your preclinical drug candidate
Chronic Kidney Disease (CKD) Models
Unilateral ureteral obstruction (UUO)
- Surgery-induced mouse model of CKD
- Renal inflammation
- Tubulointerstitial fibrosis
- Short lead-in and study duration
- Suitable for fast screening of drug therapeutic effects in CKD
Adenine diet- induced (ADI) nephropathy
- Diet-induced mouse model of CKD
- Impaired kidney function (GFR)
- Muscle wasting and anaemia
- Anti-fibrotic drug efficacy
- Suitable for profiling drug effects on GFR and renal fibrosis
Unilateral ischemia reperfusion injury (uIRI)
- Surgery-induced mouse model of CKD
- Renal inflammation
- Tubular injury and tubulointerstitial fibrosis
- Suitable for anti-fibrotic drug efficacy testing
5/6 nephrectomy model of CKD
- Industry-standard, surgery-induced rat model of CKD
- Impaired kidney function (GFR)
- Progressive albuminuria and glomerulosclerosis
- AI-assisted glomerulosclerosis scoring
- Tubulointerstitial fibrosis
- Suitable for profiling drug effects on GFR and renal fibrosis
Explore other models
Polycystic Kidney Disease (PKD)
PCK rat with Pkhd1 gene mutation
- Ongoing breeding of PCK rats
- Progressive cyst formation and kidney enlargement
- Evaluation of cyst formation using whole-kidney 3D imaging
Acute Kidney Injury (AKI) model
Bilateral Ischemia Reperfusion Injury (bIRI)
- Surgery-induced mouse model of AKI
- Bilateral temporary obstruction of blood flow
- Acute loss of renal function
- Tubular necrosis, degeneration and dilation
CKD model of Glomerulopathy
Anti-GBM glomerulonephritis
- Nephrotoxicity-induced kidney injury model
- Progressive albuminuria and glomerulosclerosis
- AI-assisted glomerulosclerosis scoring
- Tubulointerstitial fibrosis
- Profiling glomeruloprotective drug effects
CKD model of Glomerulopathy
Adriamycin-induced nephropathy
- Model of focal segmental glomerulosclerosis
- AI-assisted glomerulosclerosis scoring
- Advanced albuminuria and glomerulosclerosis
- Tubulointerstitial fibrosis
- Profiling glomeruloprotective drug effects
Related pages
For further information
Contact us
Gubra
Hørsholm Kongevej 11B
2970 Hørsholm
Denmark
+45 3152 2650