Insight Resource Library Tap into Gubra’s vast production of publications, webinars, videos and posters to get the latest knowledge and insights within our focus areas: obesity, diabetes, MASH, CKD, IPF and IBD. Filtered (23) Filters Reset all × ASBT × Bariatric surgery × Pharmacokinetics × Search × Resource type Data presentation (0) Poster (2) Publication (21) 3D imaging video (0) Webinar (0) Category × Disease model (212) Cardiovascular disease (10) AngII mouse (1) DIO-ApoE-KO mouse (1) DIO-LDLR-KO mouse (4) DIO-PCK9-AAV mouse (1) Isoprenaline-induced cardiomyopathy (1) Cholangiopathy (1) Bile duct ligation (BDL) mouse (1) Mdr2-KO mouse (1) CNS disease (39) Alzheimer's disease models (9) CNS activation (12) Drug distribution (6) Gene expression (1) Gene therapy (1) Parkinson's disease models (6) Diabetes (33) db/db mouse (17) Non-obese diabetic (NOD) mouse (4) ZDF rat (10) Inflammatory bowel disease (2) Acute DSS-IBD mouse (0) Chronic DSS-IBD mouse (2) Idiopathic pulmonary fibrosis (5) BLEO-IPF mouse (3) Chronic BLEO-IPF mouse (1) HFD-BLEO-IPF mouse (0) Kidney disease (31) Acute kidney injury (4) Bilateral ischemia reperfusion injury (bIRI) mouse (1) Unilateral ischemia reperfusion injury (uIRI) mouse (3) Chronic kidney disease (16) Anti-GBM glomerulonephritis mouse (1) Adenine diet-induced (ADI) nephropathy mouse (5) Polycystic kidney disease (PCK) rat (1) Unilateral ureteral obstruction (UUO) mouse (4) 5/6 nephrectomy (Nx) rat (2) Diabetic kidney disease (17) db/db-UNx mouse (1) ReninAAV UNx db/db mouse (11) ZSF-1 rat (0) Knock-out mouse models (8) Metabolic dysfunction-associated steatohepatitis (72) GAN DIO-MASH mouse (28) GAN DIO-MASH-HCC mouse (7) GAN ob/ob-MASH mouse (4) CDAA-HFD mouse (8) CDAA-HFD rat (9) AMLN DIO-MASH mouse (16) AMLN ob/ob-MASH mouse (12) Obesity (51) Bariatric surgery (10) DIO mouse (22) DIO rat (14) ob/ob mouse (8) Therapeutic Area (231) Alzheimer's disease (13) Alcoholic steatohepatitis (2) Cardiovascular disease (9) Chronic kidney disease (26) Cholangiopathy (1) Diabetes (55) Diabetic cardiomyopathy (2) Diabetic kidney disease (18) Hepatocellular carcinoma (5) Idiopathic pulmonary fibrosis (5) Inflammatory bowel disease (2) Metabolic dysfunction-associated steatohepatitis (80) Obesity (80) Parkinson's disease (8) Target (143) Alpha-synuclein (1) Autotaxin (1) Beta amyloid (4) Acetyl-CoA carboxylase (2) Amylin receptor (4) Angiotensin converting enzyme (ACE) (4) AMPK (1) ASBT (2) CB1 receptor (5) CCK receptor (4) D2 receptor (3) DPP-IV (2) Fatty acid synthase (1) FGF receptor-1 (3) FXR (12) GCC receptor (1) GFRAL (1) Ghrelin receptor (3) GIP receptor (4) GLP-1 receptor (71) GLP-2 receptor (5) Glucagon receptor (5) GPR119 (0) GPR120 (1) G-protein coupled receptor 10 (GPR10) (1) HSD17b13 (1) 5-HT2C receptor (3) IL-1beta receptor (1) Insulin receptor (2) mARC1 (1) MC4 receptor (4) Monoamine transporter (2) Leptin receptor (1) Neuropeptide FF receptor type 2 (1) Neurotensin receptor (1) Nicotinic acetylcholine receptor (1) NPY receptor (2) NMU receptor (2) PCSK9 (1) PICK1 (1) PPAR (22) PSD-95 (1) Renin–angiotensin system (3) Secretin receptor (1) SGLT-2 (5) TAAR1 (1) TGF-beta (5) TGR5 (2) THR-ß receptor (5) Y2 receptor (3) Compound (140) Aducanumab biosimilar (4) Adeno-associated virus (AAV)-mediated gene therapy (1) A3907 (2) Adrenomedullin (2) Alk5 inhibitor (4) ALT-801 (1) Amylin (3) Amylin receptor agonist (1) BLD-0409 (1) Bromocriptine (2) CHS-131 (1) Captopril (1) Cilofexor (1) Cotadutide (1) DA-1241 (1) Dapagliflozin (2) Dietary intervention (4) Exenatide (9) Elafibranor (9) Empagliflozin (4) Exendin-4 analogues (3) FGF21 (3) Firsocostat (2) GDF15 analogues (1) Ghrelin (1) GIP receptor agonist (1) GIPRA (1) GIP receptor antagonist (1) Glibenclamide (1) GLP-1 (5) GLP-1 receptor agonist (5) GLP-2 (1) Glucagon receptor agonist (1) Glucose-dependent insulinotropic polypeptide (GIP) (1) Guanylin (1) GUB06-046 (1) GUB08-248 (1) GUB09-123 (1) GUB09-145 (2) GUB08251 (1) GUB021794 (1) GUBamy (1) GS-834356 (1) HSD17b13 inhibitor (1) Icosabutate (1) ID166 (0) Insulin (1) INT-767 (4) INT-787 (0) Lanifibranor (9) LEAP-2 (2) Leptin (1) Linagliptin (5) Liraglutide (30) Lisinopril (4) Lorcaserin (3) MEDI0382 (1) mPD95 (1) Neuromedin U (2) Neurotensin (1) Neurturin (1) Nicotine (1) Obeticholic acid (10) Oxyntomodulin (1) PYY3-36 (4) Prolactin-releasing peptide (1) Resmetirom (6) Rimonabant (4) Rosiglitazone (2) S961 (1) Salmon calcitonin (1) SEFA-1024 (1) Seladelpar (2) Semaglutide (28) SER140 (1) Setmelanotide (3) Sibutramine (4) TAAR1 agonists (1) Taspoglutide (1) Teduglutide (2) TVB-3664 (1) UCCB01-147 (1) Uroguanylin (1) Y2 receptor agonist (1) ZP3022 (3) Method/Endpoint (253) 3D imaging (55) Adeno-associated virus (AAV)-mediated gene delivery (14) Atherosclerotic plaques (3) Beta-cell mass (12) Blood pressure (1) Body composition (11) Body weight (115) Blood biochemistry (77) Bariatric surgery (12) Bioinformatics (101) c-Fos activation (19) Clinical trial (2) Conditioned taste aversion test (1) Drug discovery (25) Drug distribution (11) Energy expenditure monitoring (4) Echocardiography (ECG) (3) Flow cytometry (1) Gut biopsy (6) Glomerular filtration rate (GFR) (7) Gastric emptying (3) Gut morphometry (11) Glucose-stimulated insulin secretion (GSIS) (1) Histopathology score (71) Heart morphometry (4) Intraperitoneal glucose tolerance test (IPGTT) (7) Image analysis (138) Immunohistochemistry (IHC) (136) In situ hybridization (ISH) (14) Insulin tolerance test (ITT) (2) Kidney biopsy (2) Kidney morphometry (22) Lung functional test (3) Light sheet fluorescence microscopy (LSFM) (58) Liver biopsy (64) Liver morphometry (62) Lung biochemistry (2) Laser-capture microdissection (LCM) (9) Magnetic resonance imaging (MRI) (2) Microbiomics (5) Micro-computed tomography (micro-CT) (1) Neurobehavior (6) Next-generation sequencing (44) Nephrectomy (14) Oral glucose tolerance test (OGTT) (20) Pancreatectomy (1) Peptide chemistry (14) Pharmacokinetics (9) Proteomics (1) qPCR (1) Real-time food intake/activity analysis (32) Receptor binding (3) Roux-en-Y gastric bypass (RYGB) (8) RNA sequencing (79) Single-cell RNA sequencing (3) Single-nucleus RNA sequencing (6) siRNA (1) StreaMLine (1) Surgery (12) Spirometry (3) Stereology (29) Stereotaxic injection (2) Ultrasound imaging (1) Urine biochemistry (12) Vasculature (2) Vertical sleeve gastrectomy (1) Western Blotting (1) Whole-body plethysmography (2) Whole-brain in situ hybridization (3) Species (207) Hamster (1) Human (28) Mouse (166) Minipig (2) Non-human primate (3) Pig (3) Rat (32) Show (23) Cancel Sort result Default sorting By title: alphabetical By title: reverse By date: oldest first By date: newest first Reset all × ASBT × Bariatric surgery × Pharmacokinetics × 23 resource library items found PosterPharmacokinetics of a long-acting GLP-1 receptor agonist in minipigs PublicationA3907, a systemic ASBT inhibitor, improves cholestasis in mice by multi-organ activity and shows translational relevance to humans PublicationLipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect PosterA3907, a novel inhibitor of bile acid transport in the intestine and the kidney, improves markers of metabolic and hepatic pathology and reduces NAFLD activity score and fibrosis stage in a diet-induced and biopsy-confirmed mouse model of nonalcoholic steatohepatitis PublicationTranscriptomic changes in pancreatic islets, adipose and liver after Roux-en-Y gastric bypass in a diet-induced obese rat model PublicationGut mucosal gene expression and metabolic changes after Roux-en-Y gastric bypass surgery PublicationIdentification and metabolic profiling of a novel human gut-derived LEAP2 fragment PublicationGlobal transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss PublicationInvestigating intestinal glucagon after Roux-en-Y gastric bypass surgery PublicationThe preprohormone expression profile of enteroendocrine cells following Roux-en-Y gastric bypass in rats PublicationBariatric surgery in patients with non-alcoholic fatty liver disease – from pathophysiology to clinical effects PublicationNovel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice PublicationChemical Strategies for Half-life Extension of Biopharmaceuticals: Lipidation and its Alternatives PublicationGuanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control PublicationGUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice PublicationPeptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues PublicationA hydrogel-microsphere drug delivery system that supports once-monthly administration of a GLP-1 receptor agonist PublicationThe endogenous preproglucagon system is not essential for gut growth homeostasis in mice PublicationNeoglycolipids for prolonging the effects of peptides: Self-assembling glucagon-like peptide 1 analogues with albumin binding properties and potent in vivo efficacy PublicationEffects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery PublicationAlterations in hypothalamic gene expression following Roux-en-Y gastric bypass PublicationSynthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake PublicationPost-surgical effects of Roux-en-Y gastric bypass on glucose homeostasis, intestinal morphology and L-cells in obese Göttingen minipigs For further information Contact us Gubra Hørsholm Kongevej 11B 2970 Hørsholm Denmark +45 3152 2650