Publication

Identification and metabolic profiling of a novel human gut-derived LEAP2 fragment

Journal of Clinical Endocrinology and Metabolism 106(2):e966-e981, 2021

Hagemann CA, Zhang C, Hansen HH, Jorsal T, Rigbolt KTG, Madsen MR, Bergmann NC, Heimbürger SMN, Falkenhahn M, Theis S, Breitschopf K, Holm S, Hedegaard MA, Christensen MB, Vilsbøll T, Holst B, Vrang N, Jelsing J, Knop FK

Subjects
HumanDIO mouseTargetDIO ratMouseCompoundMethod/EndpointDiabetesSpeciesBody weightBlood biochemistryBariatric surgeryObesityDrug discoveryEnergy expenditure monitoringGhrelin receptorGlucose-stimulated insulin secretion (GSIS)Gut biopsyImage analysisImmunohistochemistry (IHC)In situ hybridization (ISH)GLP-1Laser-capture microdissection (LCM)Real-time food intake/activity analysisRoux-en-Y gastric bypass (RYGB)LEAP-2RNA sequencing

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