Publication

Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect

Scientific Reports 12:1696, 2022

Alexopoulou F, Bech EM, Pedersen SL, Thorbek DD, Leurs U, Rudkjær LCB, Fosgerau K, Hansen HH, Vrang N, Jelsing J, Elster L

Subjects
Therapeutic AreaDIO mouseTargetMouseCompoundMethod/EndpointSpeciesBody weightObesityDrug discoveryG-protein coupled receptor 10 (GPR10)Neuropeptide FF receptor type 2GUB08-248GUB08251Peptide chemistryPharmacokineticsReal-time food intake/activity analysisReceptor bindingProlactin-releasing peptideSemaglutide

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