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Nephroprotective effects of semaglutide in a preclinical model of hypertensive diabetic kidney disease

In this webinar, Gubra’s experts on preclinical DKD models, Principal Scientists Mette Østergaard and Henrik Björk Hansen, will discuss the effects of semaglutide on renal functional, histological and gene expression markers of advanced DKD in the db/db UNx-ReninAAV mouse.

Adeno-associated virus (AAV)-mediated gene deliveryReninAAV UNx db/db mouseMouseChronic kidney diseaseBody weightBlood biochemistryDiabetic kidney diseaseBioinformaticsGLP-1 receptorHistopathology scoreImage analysisImmunohistochemistry (IHC)Kidney morphometryNext-generation sequencingNephrectomyRNA sequencingUrine biochemistrySemaglutide

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