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Webinar

Lost in translation – how to improve the translatability of rodent models of diabetic kidney disease

Senior scientist Mette Viberg Østergaard introduces to the challenges of using current rodent models of diabetic kidney disease in drug discovery and development. Mette then presents an example of how translatability may be improved in a model of diabetic kidney disease in the setting of type 2 diabetes and hypertension.

Subjects
3D imagingAdeno-associated virus (AAV)-mediated gene deliveryChronic kidney disease (CKD) modelsReninAAV UNx db/db mouseMouseBody weightBlood biochemistryDiabetic kidney disease (DKD)Image analysisImmunohistochemistry (IHC)Kidney morphometryNext-generation sequencingNephrectomyUrine biochemistry

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