Publication

Nephroprotective effects of semaglutide as mono- and combination treatment with lisinopril in a mouse model of hypertension-accelerated diabetic kidney disease

Biomedicines 10(7):1661, 2022

Dalbøge LS, Christensen M, Madsen MR, Secher T, Endlich N, Drenic´ V, Manresa-Arraut A, Hansen HH, Rune I, Fink LN, Østergaard MV

Subjects
Adeno-associated virus (AAV)-mediated gene deliveryReninAAV UNx db/db mouseMouseChronic kidney diseaseAngiotensin converting enzyme (ACE)Body weightBlood biochemistryDiabetic kidney diseaseBioinformaticsGLP-1 receptorHistopathology scoreImage analysisImmunohistochemistry (IHC)Kidney morphometryNext-generation sequencingNephrectomyRenin–angiotensin systemRNA sequencingSingle-cell RNA sequencingLisinoprilUrine biochemistrySemaglutide

Share this page

Resource Library

Related resources
Publication
Rationale and design of a prospective, clinical study of kidney biopsies in people with type 2 diabetes and severely increased albuminuria (the PRIMETIME 2 study)
Publication
Automated image analyses of glomerular hypertrophy in a mouse model of diabetic nephropathy
Poster
Renal cell-type associated therapeutic effects of semaglutide in a mouse model of hypertension accelerated diabetic kidney disease
Poster
Transcriptomic profiling of renal cortical and glomerular changes in a uninephrectomized, hypertension-accelerated mouse model of advanced diabetic kidney disease

For further information

Contact us

Gubra

Hørsholm Kongevej 11B
2970 Hørsholm
Denmark

+45 3152 ­2650

Back To Top