Publication

Nephroprotective effects of semaglutide as mono- and combination treatment with lisinopril in a mouse model of hypertension-accelerated diabetic kidney disease

Biomedicines 10(7):1661, 2022

Dalbøge LS, Christensen M, Madsen MR, Secher T, Endlich N, Drenic´ V, Manresa-Arraut A, Hansen HH, Rune I, Fink LN, Østergaard MV

Subjects
Adeno-associated virus (AAV)-mediated gene deliveryReninAAV UNx db/db mouseMouseChronic kidney disease (CKD)Angiotensin converting enzyme (ACE)Body weightBlood biochemistryDiabetic kidney disease (DKD)BioinformaticsGLP-1 receptorHistopathology scoreImage analysisImmunohistochemistryKidney morphometryRenin–angiotensin systemNext-generation sequencingNephrectomyLisinoprilRNA sequencingSingle-cell RNA sequencingUrine biochemistrySemaglutide

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