Publication

Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese-diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries

Molecular Metabolism 55:101392, 2021

Boland BB, O’Brien S, Sermadiras I, Nielsen JC, Barkholt P, Roostalu U, Hecksher-Sørensen J, Sejthen SR, Thorbek DD, Suckow A, Burmeister N, Oldham S, Will S, Howard VG, Gill BM , Newton P, Naylor J, Sitaula S, Laker RC, Hornigold DC, Austin J, Lantier L, McGuiness OP, Trevaskis JL, Grimsby JS, Rhodes CJ

Subjects
3D imagingdb/db mouseTherapeutic AreaDIO mouseCNS activationMouseTargetCompoundMethod/EndpointDiabetesSpeciesKnock-out mouse modelsBioinformaticsc-Fos activationConditioned taste aversion testObesityGLP-1 receptorImmunohistochemistryGLP-1 receptor agonistLight sheet fluorescence microscopy (LSFM)Laser-capture microdissection (LCM)Y2 receptorRNA sequencingPYY3-36

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