Publication

Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates

Diabetes Obesity and Metabolism 18(12):1176–1190, 2016

Henderson SJ, Konkar A, Hornigold DC, Trevaskis JL, Jackson R, Fritsch Fredin M, Jansson-Löfmark R, Naylor J, Rossi A, Bednarek MA, Bhagroo N, Salari H, Will S, Oldham S, Hansen G, Feigh M, Klein T, Grimsby J, Maguire S, Jermutus L, Rondinone CM, Coghlan MP

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Subjects

DIO mouse Therapeutic Area Target Compound Method/Endpoint Non-human primate Diabetes Species Obesity Energy expenditure monitoring GLP-1 receptor Glucagon receptor Intraperitoneal glucose tolerance test (IPGTT)Liraglutide MEDI0382 Oxyntomodulin

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