Background & aim: Psychiatric compounds modulate complex brain networks, making whole-brain assessment of neuronal activity essential for understanding their mechanisms of action. Activity-dependent genes such as c-Fos, and other stimulus-regulated genes (SRGs) provide complementary molecular readouts of neuronal activation, and…
Background & aim: Central regulation of appetite and satiety engages neuronal populations distributed across the brain. The identification of novel drug targets, development of anti-obesity therapeutics, and validation of their mode of action benefit from whole-brain imaging. Light-sheet fluorescence…
Background & aim: Neurodegenerative diseases are characterized by complex, large-scale structural and cellular alterations across the brain. Understanding these changes requires comprehensive, whole-brain analysis at high spatial resolution. Three-dimensional light sheet fluorescence microscopy (3D LSFM) enables rapid imaging of intact…
Speaker Urmas Roostalu Urmas is department manager for 3D Imaging and work in his team is focused on high throughput sample preparation and microscopy of proteins, mRNAs, and pharmacological compounds in whole organs. He has PhD in molecular biology and…
Journal of Clinical Endocrinology and Metabolism 106(2):e966-e981, 2021
