Publication
Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis
Nature Metabolism 2(5):413–431, 2020
Boland ML, Laker RC, Mather K, Nawrocki A, Oldham S, Boland BB, Lewis H, Conway J, Naylor J, Guionaud S, Feigh M, Veidal SS, Lantier L, McGuinness OP, Grimsby J, Rondinone CM, Jermutus L, Larsen MR, Trevaskis JL, Rhodes CJ
Therapeutic AreaDIO mouseMouseTargetCompoundMethod/EndpointAMLN DIO-MASH mouseSpeciesAMLN ob/ob-MASH mouseBody weightBlood biochemistryMetabolic dysfunction-associated steatohepatitisCotadutideGLP-1 receptorGlucagon receptorHistopathology scoreIntraperitoneal glucose tolerance test (IPGTT)Image analysisLiver biopsyLiver morphometryReal-time food intake/activity analysisLiraglutideObeticholic acid
Share this page
Related resources
For further information
Contact us
Gubra
Hørsholm Kongevej 11B
2970 Hørsholm
Denmark
+45 3152 2650