Preclinical CRO Services in

Kidney Diseases
(CKD, DKD and AKI)

We specialize in providing high-end preclinical models tailored for your studies within chronic kidney disease (CKD), diabetic kidney disease (DKD), and acute kidney injury (AKI). Our translational models are instrumental for characterizing preclinical drug candidates and benchmark against current treatments. We offer full-service solutions in preclinical drug development. Partner with us to unlock new insights into kidney health and drive innovation in target and drug discovery.

Why Choose Gubra?

Expert scientific guidance in drug efficacy studies
Full-service CRO with a wide range of translational disease models
Individually tailored study design to meet your research objectives
AI-assisted endpoint quantification for accurate and conclusive data
Pharmacology, biomarkers, histology and whole-kidney 3D imaging

Consult with Michael Christensen

Principal Scientist, Scientific Sales

Get expert advice on choosing the right model for your project.

Discover Our Extensive Range of Models for Kidney Disease Research

Discover our advanced rodent models of various kidney diseases. We employ industry-standard and state-of-the-art models to address therapeutic effects of your specific drug treatment concept. We ensure translatability by comprehensive model validation and incorporating clinical endpoints. Ready to delve deeper?

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Main study offerings

Glomerular filtration rate

Quantitative
fibrosis scoring

Quantitative 3D whole kidney imaging

Plasma & urine markers

AI-assisted glomerulosclerosis scoring

Surgical expertise
& know-how

Profile your preclinical drug candidate

Preclinical Models of Diabetic Kidney Disease (DKD)

ReninAAV UNx db/db mouse model

State-of-the-art model of DKD
Progressive albuminuria and glomerulosclerosis
Unbiased AI-assisted glomerulosclerosis scoring
Validated using standard of care (SoC) benchmark
Ideal for profiling mono- and combination therapies

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Profile your preclinical drug candidate

Preclinical Models of Chronic Kidney Disease (CKD)

Unilateral ureteral obstruction (UUO) mouse model

Surgery-induced model of CKD
Robust renal inflammation
Tubulointerstitial fibrosis
Short lead-in and study duration
Suitable for fast screening of drug efficacy

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Adenine diet-induced (ADI) CKD mouse model

Fast onset and progression of CKD
Impaired kidney function (GFR)
Exhibits muscle wasting and anaemia
Robust kidney fibrosis
Ideal for profiling drug effects on GFR and renal fibrosis

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Unilateral ischemia reperfusion injury (uIRI) mouse model

Surgery-induced model of CKD
Fast onset and progression of CKD
Tubular injury
Ideal for profiling drug effects on renal inflammation and fibrosis

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5/6 nephrectomy rat model

- Surgery-induced model of CKD and kidney failure
- Progressive albuminuria and loss of kidney function
- Glomerulosclerosis and tubulointerstitial fibrosis
- Ideal for profiling drug effects on GFR and renal fibrosis

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Discover other kidney disease models at Gubra

Polycystic Kidney Disease (PKD) model

PCK rat with Pkhd1 gene mutation

Continuously breeding of PCK rats for intervention studies
Progressive cyst formation and kidney enlargement
Whole-kidney 3D imaging for total cyst load

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Acute Kidney Injury (AKI) model

Bilateral Ischemia Reperfusion Injury (bIRI) mouse model

- Surgery-induced AKI
- Bilateral temporary obstruction of blood flow to simulate severe renal stress
- Rapid loss of renal function
- Tubular necrosis, degeneration and dilation
- Ideal for drug intervention studies

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