Skip to content
Poster

Prophylactic and therapeutic effects of the dual FXR/TGR5 agonist INT-767 in the GAN diet-induced ob/ob mouse model of advanced MASH with progressive fibrosis

Background & Aim:
The farnesoid X receptor (FXR) and G-protein-coupled bile acid receptor (TGR5, Gpbar1) have both been implicated in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH).

The present study aimed to evaluate the efficacy of the dual FXR/TGR5 agonist INT-767 on therapeutic outcomes in an accelerated genetically obese mouse model of MASH with progressive fibrosis.

Subjects
MouseGAN ob/ob-MASH mouseBody weightBlood biochemistryMetabolic dysfunction-associated steatohepatitisFXRHistopathology scoreImage analysisImmunohistochemistry (IHC)Liver biopsyLiver morphometryINT-767TGR5

For further information

Contact us

Gubra

Hørsholm Kongevej 11B
2970 Hørsholm
Denmark

+45 3152 ­2650

Back To Top