When it comes to preclinical kidney disease research, Gubra stands out for offering a diverse and innovative range of animal models tailored to study chronic kidney disease (CKD), diabetic kidney disease (DKD), acute kidney injury (AKI), and related renal conditions. One model sets Gubra apart: the ReninAAV UNx db/db mouse model is a highly complex and advanced representation of human DKD, as it encompasses the major risk factors for developing DKD, including obesity, hyperglycemia, and hypertension. This model is our flagship offering, designed for precision and reliability in mimicking human renal disease conditions. Read through a list of key preclinical kidney disease models Gubra offers, find what their key features are and what their application is.
1. ReninAAV UNx db/db Mouse Model
- Description:
- Hypertension accelerated diabetic kidney disease
- Key Features:
- State-the-art model of DKD
- Progressive albuminuria and glomerulosclerosis
- Validated using standard of care treatments
- Application:
- Robust model for testing effects on albuminuria as well as glomerulosclerosis
- Why it’s unique:
- This model displays the most critical risk factors for developing DKD including obesity, hyperglycaemia and hypertension. Gubra’s expertise and advanced methodologies make the ReninAAV UNx dbdb mouse model one of the most reliable and translatable options available. Its ability to closely mirror the human disease makes it an invaluable tool for researchers aiming to develop effective treatments for DKD.
Mapping Progression of DKD in ReninAAV UNx db/db mice utilizing time-series RNA sequencing
Renal cell-type associated therapeutic effects of semaglutide in a mouse model of hypertension accelerated diabetic kidney disease
2. Unilateral Ureteral Obstruction (UUO) Mouse Model
-
- Description:
- A surgically induced CKD model that causes renal inflammation and tubulointerstitial fibrosis
- Key Features:
- Surgical induced and very reliable model of CKD
- Robust induction of renal inflammation and fibrosis
- Short study duration and conclusive data
- Application:
- Suitable for fast screening of multiple compounds and doses
- Description:
3. Adenine Diet-Induced (ADI) CKD Mouse Model
-
- Description:
- A dietary model of CKD that induces renal impairment through adenine consumption
- Key Features:
- Fast diet induced onset and progressions of CKD
- Impaired kidney function
- Robust induction of renal inflammation and fibrosis
- Application:
- Ideal for profiling drug effects on GFR and renal fibrosis
- Description:
4. 5/6 Nephrectomy Rat Model
-
- Description:
- A classic CKD model achieved by surgically removing five-sixths of the renal mass, leading to gradual kidney failure
- Key Features:
- Advanced surgically induced model of CKD
- Profound loss of kidney function
- Progressive albuminuria, glomerulosclerosis and tubulointerstitial fibrosis
- Application:
- Ideal for profiling drug effects on kidney function and renal fibrosis
- Description:
5. Bilateral Ischemia Reperfusion Injury (bIRI) Mouse Model
-
- Description:
- An AKI model created by temporarily obstructing blood flow to both kidneys
- Key Features:
- Surgical induction of rapid loss of renal function
- Histopathological assessment of tubular necrosis, degeneration, hyaline casts and dilation
- Application:
- Suited for testing of compounds that can attenuate AKI or conserve kidney function
- Description:
6. Anti-Glomerular Basement Membrane (GBM) Mouse Model
-
- Description:
- An immune-mediated CKD model characterized by glomerular inflammation and injury
- Key Features:
- Model for glomerular nephritis
- Progressive development of albuminuria and glomerulosclerosis
- Development of tubulointerstitial fibrosis
- Application:
- Ideal for profiling of glomerular protective drug effects
- Description:
7. PCK Rat Model of Polycystic Kidney Disease (PKD)
-
- Description:
- An immune-mediated CKD model characterized by glomerular inflammation and injury
- Key Features:
- Progressive cyst formation and kidney enlargement
- Progressive albuminuria and impairment of renal function
- Whole-kidney 3D imaging for total cyst quantification
- Application:
- Suited for evaluation of effects of cyst formation and renal function in PKD
- Description:
Why choose Gubra’s preclinical kidney models?
Gubra’s range of preclinical kidney disease models is unparalleled, offering reliable and translational platforms to explore therapeutic interventions. The ReninAAV UNx db/db mouse model, in particular, has garnered attention for its ability to replicate the complexity of human DKD, making it an essential tool for any groundbreaking kidney disease research.
Contact us to learn more
Whether you are focused on CKD, DKD, AKI, or specific renal pathologies like glomerulopathy or polycystic kidney disease, Gubra’s preclinical models can accelerate your drug discovery and development efforts. Connect with our experts to explore how our models can be tailored to your research needs here.