Cro services in
Diabetes
At Gubra we have decades of scientific expertise in conducting preclinical studies using animal models of type 1 and type 2 diabetes. We can provide end-to-end study design, and comprehensive data combining in vivo metabolic profiling with hormonal analysis, histology, 3D imaging and RNAseq to evaluate the impact of your anti-diabetic drug candidate.
Why choose Gubra?
-
Expert scientific guidance within diabetes
-
Extensive experience in anti-diabetic drug profiling
-
Wide range of diabetic animal models
-
Tailored study design and rapid initiation
-
Combination of pharmacology, histology and 3D imaging
Consult with Marco Tozzi
Senior Scientist, Scientific Sales
Advance your diabetes drug development with our extensive knowhow.
Decades of experience in anti-diabetes drug profiling
We have extensive knowhow in conducting preclinical studies using animal models of type 1 and type 2 diabetes. Our technical expertise includes working with difficult models such as ZDF rats, db/db or NOD mice as well as quantifying beta-cell mass and other histological-pathological endpoints of diabetes.
Main Offerings
Diabetic rodent models
Treatment efficacy studies
Full metabolic
assessment services
Glucose homeostasis
evaluation
Insulin sensitivity testing
Islets and β-cells
quantification
We work with all the most common models of diabetes
Models of Diabetes
db/db mouse
-
Deficient leptin receptor signalling
-
Morbid obesity and impaired glucose tolerance
-
Early phenotype of type 2 diabetes
-
Well-defined progression in islet pathology
-
Suitable for treatment intervention
- Validated with several anti-diabetic drug classes
ZDF rat
-
Deficient leptin receptor signalling
-
Morbid obesity and impaired glucose tolerance
-
Early phenotype of type 2 diabetes
-
Well-defined progression in islet pathology
-
Suitable for treatment intervention
- Validated with several anti-diabetic drug classes
NOD mouse
-
Standard model of type 1 diabetes
-
Well-defined progression in islet pathology
-
Sustained hyperglycemia
-
Age/sex-dependent transition to diabetes
-
Validated with several anti-diabetic drug classes
STZ mouse/rat
- Streptozotocin (STZ)-induced β-cells depletion
- 100% response rate using medium-dose STZ
- Fast and predictable induction of insulin deficiency
- Robust and stabile hyperglycemia
- Suitable for treatment intervention
- Validated with several anti-diabetic drug classes
Related pages
For further information
Contact us
Gubra
Hørsholm Kongevej 11B
2970 Hørsholm
Denmark
+45 3152 2650