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Novel NPY2R agonist BI 1820237 provides synergistic anti-obesity efficacy when combined with the GCGR/GLP-1R dual agonist survodutide

Molecular Metabolism 102205, 2025 (online ahead of print). Augustin R, Oldenburger A, Baader-Pagler T, Zimmermann T, Borghardt J, Hecksher-Sørensen J, Baljuls A, Reindl W, Krawczyk B, Martel E, Brennauer A, Peters S, Grube A, Rudkjaer LB, Haebel P.

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3D imaging BI 1820237 CNS activation Mouse c-Fos activation Obesity GLP-1 receptor Glucagon receptor Image analysis Light sheet fluorescence microscopy (LSFM)NPY receptor Survodutide

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Novel NPY2R agonist BI 1820237 provides synergistic anti-obesity efficacy when combined with the GCGR/GLP-1R dual agonist survodutide

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