Systemic inhibition of soluble TNF significantly changes glial cell populations leading to improved myelin integrity and better functional outcome after experimental stroke
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Development and characterization of a humanized GLP-1 receptor mouse model for translational drug development
Background & aim: Injectable peptide-based GLP-1 receptor agonists (GLP1RAs) are effective treatments for obesity and type 2 diabetes, yet present challenges related to patient compliance and scalable production. In contrast, small-molecule GLP1RAs offer significant advantages, including oral bioavailability and scalable…
3D whole-brain imaging of parenchymal/vascular amyloid plaque architecture during disease progression in a transgenic mouse model of Alzheimer’s disease
Background & Aim: Alzheimer’s disease (AD) is histologically defined by accumulation of Abeta (Aβ) plaques in the brain. Age and gender are important factors in AD pathology. To develop more effective interventions, preclinical studies should therefore consider these factors in…
Transferrin receptor-binding blood-brain barrier shuttle enhances brain delivery and efficacy of a therapeutic anti-Aβ antibody
Background & Aim: Improved CNS access of amyloid β (Aβ)-directed antibodies may increase therapeutic benefits while also reducing dose-dependent adverse effects of this drug class. Using light sheet fluorescence microscopy (LSFM), we 3D mapped and quantified brain delivery, distribution and…
