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Poster

Transferrin receptor-binding blood-brain barrier shuttle enhances brain delivery and efficacy of a therapeutic anti-Aβ antibody​

Background & aim:
Improved CNS access of amyloid β (Aβ)-directed antibodies may increase therapeutic benefits while also reducing dose-dependent adverse effects of this drug class. Using light sheet fluorescence microscopy (LSFM), we 3D mapped and quantified brain delivery, distribution and efficacy of a blood-brain barrier (BBB) shuttle-enhanced therapeutic anti-Aβ antibody in a mouse model of Alzheimer’s disease (AD).

Subjects
3D imagingAlzheimer's diseaseAlzheimer's disease modelsAducanumabMouseBeta amyloidBioinformaticsDrug distributionImmunohistochemistry (IHC)Light sheet fluorescence microscopy (LSFM)

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