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Single-cell Transcriptomic Profiling of MASH-HCC Development

Background & aim:

Cellular-level insights into metabolic associated steatohepatitis (MASH) and its progression to hepatocellular carcinoma (HCC) have been limited by bulk RNA-sequencing, which masks rare or tumor-relevant populations. Here, we applied single-cell transcriptomics to characterize liver cell-specific transcriptome changes in the GAN DIO-MASH-HCC mouse – a gold-standard translational model of MASH-driven HCC. The current study aimed to construct a comprehensive liver single-cell atlas of the healthy mouse, the GAN DIO-MASH and GAN DIO-MASH-HCC mouse models.

Subjects

GAN DIO-MASH mouse GAN DIO-MASH-HCC mouse Mouse Bioinformatics Metabolic dysfunction-associated steatohepatitis Liver biopsy Next-generation sequencing RNA sequencing Single-cell RNA sequencing

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