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Poster

Molecular Hallmarks of Lung Cellular Senescence in the Repetitive Bleomycin-induced and Spirometry-confirmed Mouse Model of IPF

Background & aim:

Growing evidence suggests that senescent cells contribute to the development and progression of idiopathic pulmonary fibrosis (IPF).

This study aimed to identify and characterize key markers of lung senescence using a repetitive bleomycin-induced (BLEO), spirometry-confirmed mouse model of IPF.

Subjects
Chronic BLEO-IPF mouseMouseIdiopathic pulmonary fibrosisHistopathology scoreImage analysisImmunohistochemistry (IHC)Lung functional testLung biochemistryRNA sequencingWhole-body plethysmography
Related resources
Poster
Repetitive installations of bleomycin induce persistent progressive lung fibrosis in a mouse model of IPF

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