GUBox, a dual Ox1R/Ox2R peptide agonist, promotes wakefulness and reduces cataplexy in orexin/ataxin3 mice

Aim:

Utilize orexin analogues to activate central orexin signaling and compensate for the loss of endogenous orexin function in Narcolepsy Type 1 (NT1).

How? Engineering highly potent dual orexin receptor (OxR) 1 and OxR2 agonists from orexin backbone with optimized pharmacokinetic (PK) and physiochemical properties using our StreaMLine platform (sML).