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EXPERTS IN PEPTIDE DRUG DISCOVERY AND DEVELOPMENT​

Discovery, Development & Partnerships

We are advancing next-generation peptide therapeutics through a focused, data-driven discovery engine, rooted in years of peptide drug discovery and strengthened by selected strategic partnerships.

Collaboration with Gubra

Drug Discovery and Development​
Combine deep peptide expertise with AI-driven discovery to rapidly deliver development candidates and advance successful programs.

R&D Pipeline
Explore our robust and growing pipeline of peptide pre-clinical and clinical programs.

streaMLine Platform ​
Synthesize and screen thousands of peptides, using machine-learning and advanced models to accelerate drug discovery.​

Partnerships​
Partner with us to develop tomorrow’s novel peptide therapeutics.​

balanced portfolio of internal & partnered programs

Gubra’s R&D Pipeline

Gubra’s R&D pipeline is driven by a strong focus on peptide drug discovery and development. We are advancing a growing portfolio of programs across key therapeutic areas, including metabolic, endocrine, and hematological disorders. Our deep expertise in peptides enables us to discover and develop innovative drug candidates, both through our proprietary initiatives and in close collaboration with strategic partners.

Project
Disease Area
Partner
Drug Discovery
Pre-Clinical
Phase 1
UCN2
Obesity
Gubra

Background

With current weight loss treatments, 20–40% of body weight reduction comes from unwanted loss of lean mass (muscles, bones, internal organs). Gubra’s UCN2 program is developed for high quality weight loss. In preclinical models UCN2 prevented incretin induced lean mass loos while enhancing fat mass reduction.

Compound

Urocortin-2 analogue and a potent and highly selective Corticotropin-releasing hormone receptor 2 (CRHR2) agonist that has been designed for weekly dosing.

Internal

Gubra

Orexin
Narcolepsy
Gubra

Background

Narcolepsy type 1 is characterized by the loss of hypothalamic neurons producing orexin (hypocretin), a neuropeptide critical for maintaining wakefulness. Orexin receptor agonists activate orexin receptors (OX1R/OX2R), compensating for the deficiency. This mechanism directly targets the underlying pathophysiology, offering a therapeutic potential to improve clinical symptoms such as excessive daytime sleepiness and cataplexy.

Compound

A novel, peptide-based dual orexin receptor agonist designed to restore the underlying orexin deficiency and reestablish normal wakefulness regulation.

Internal

Gubra

GLP-1
Obesity
Gubra

Background

Injectable peptide-based GLP-1 receptor (GLP1R) agonists have shown remarkable therapeutic success in the treatment of type2 diabetes and obesity, as a monotherapy or in combinations.

Compound

Potent and selective GLP-1 receptor agonist ​from secretin backbone with good formulation properties​ excellent in vivo efficacy and PK properties.

Internal

Gubra

PTH
Hypoparathyroidism
Gubra

Background

Hypoparathyroidism is a rare endocrine disorder in which the body produces insufficient levels of parathyroid hormone (PTH). PTH is crucial for regulating and maintaining a balance of calcium and phosphorus in the body. Low PTH levels lead to hypocalcemia and hyperphosphatemia, which can lead to muscle cramps, tingling sensations, and in severe cases, seizures or cardiac issues.

Compound

A novel, peptide-based PTH receptor agonist designed to restore calcium and phosphate levels in patients suffering from hypoparathyroidism.

Internal

Gubra

Undisclosed
Obesity
Gubra

Background

Despite significant advancements with approved anti-obesity medications, a substantial medical need persists. Current therapies, while effective for many, often fall short in delivering sustained, long-term and muscle preserving weight loss.

Compound

Undisclosed

Internal

Gubra

Amylin
Obesity
AbbVie

Background

AbbVie and Gubra announced a license agreement to develop an amylin analog for the treatment of obesity. The agreement enables the incorporation of GUB014295, an amylin analogue discovered and developed by Gubra, into AbbVie's global infrastructure (ABBV-295). Amylin is a naturally occurring hormone secreted by pancreatic beta cells that plays a crucial role in energy balance and glucose homeostasis. As a satiety signal, it activates pathways in the brain to suppress appetite and reduce food intake.

Compound

A long-acting amylin analog.

Partner

Abbvie

Clinical

The Phase 1 clinical trial is a two-part, single center, double-blind (within cohorts), randomized, placebo-controlled, single (Part 1) and multiple (Part 2) ascending subcutaneous dose study of GUB014295. Part 1 has been completed; Part 2 is ongoing. More information on this trial can be found at https://www.clinicaltrials.gov/ (NCT: 06144684).

NPY2R agonist
Undisclosed
Boehringer Ingelheim

Background

BI 1820237, which is fully outlicensed to Boehringer Ingelheim, is a long-acting neuropeptide Y receptor type 2 (NPY2R) agonist. In October 2024, Boehringer Ingelheim discontinued its development for obesity. Potential opportunities outside the obesity indication are now being explored by Boehringer Ingelheim.

Compound

Undisclosed

Partner

BI

Triple agonist
Obesity
Boehringer Ingelheim

Background

BI 3034701, fully outlicensed to Boehringer Ingelheim, is a triple agonist peptide.

Compound

A long-acting triple agonist peptide with a potential to become a next-generation and first-in-class obesity treatment.

Partner

BI

Clinical

The Phase 1, first-in-human, randomized, placebo-controlled trial, will assess safety, tolerability, and pharmacokinetics of the drug candidate (BI 3034701). The trial has 2 parts. Part A is open to healthy men between 18 and 55 years of age. Part B is open to people between 18 and 65 years of age with overweight or obesity who are otherwise healthy.

Undisclosed
Obesity
Boehringer Ingelheim

Background

Building on a longstanding partnership, Boehringer Ingelheim and Gubra continue their collaborative efforts to identify and validate novel peptide-based therapies for obesity. Leveraging complementary strengths in Research and Development , the partnership aims to deliver innovative peptide treatments to improve health outcomes for people living with obesity.

Compound

Undisclosed

Partner

BI

Undisclosed
Obesity
Boehringer Ingelheim

Background

Further building on their history of successful partnership, Gubra and Boehringer Ingelheim have entered a collaboration taking a new approach to discover novel peptides to deliver innovative treatments with the aim of improving health outcomes for people living with obesity.

Compound

Undisclosed

Partner

BI

GLP-1R antagonist
PBH & Other Rare Diseases
Amylyx

Background

Collaboration with Amylyx Pharmaceuticals to develop a novel long-acting GLP-1 Receptor Antagonist.

Compound

Undisclosed

Partner

Amylyx

Undisclosed
Bleeding Disorder
Hemab

Background

Undisclosed

Compound

Undisclosed

Partner

Hemab

MACHINE LEARNING-ASSISTED ANALYSIS OF THOUSANDS OF PEPTIDES​

StreaMLine​


At Gubra, we continuously advance our knowledge and innovate our technology. Visit our resource library to explore the latest publications on streaMLine, our in-house machine-learning platform. ​

We believe the most meaningful innovations happen together


That’s why we are eager to collaborate with forward-thinking partners to co-create transformative therapeutic options, blending our expertise to drive science and value forward.

Related pages

For further information

Contact us

Gubra

Hørsholm Kongevej 11B
2970 Hørsholm
Denmark

+45 3152 ­2650

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