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Poster

Mapping Progression of DKD in ReninAAV UNx db/db mice utilizing time-series RNA sequencing

Background & Aim:

The adeno-associated virus-mediated renin (ReninAAV) overexpressing and uninephrectomized (UNx) db/db mouse model of diabetic kidney disease (DKD)recapitulates hallmarks of DKD complicated by hypertension. Gaps persist in our understanding regarding temporal patterns of glomerular gene expression and pathophysiology during hypertensive DKD. The present longitudinal study therefore characterized glomerular transcriptome changes during disease progression in the ReninAAV-UNx db/db mouse.

Subjects
Adeno-associated virus (AAV)-mediated gene deliveryReninAAV UNx db/db mouseMouseBody weightDiabetic kidney diseaseBlood biochemistryBioinformaticsHistopathology scoreImmunohistochemistry (IHC)Kidney biopsyLaser-capture microdissection (LCM)RNA sequencingUrine biochemistry

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