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Poster

Effect of lisinopril on glomerular and tubular injury in a surgical rat model of progressive chronic kidney disease and kidney failure

Background & Aim
The 5/6 nephrectomy (Nx) rat model of CKD displays progressive albuminuria, glomerulosclerosis, tubulointerstitial fibrosis, and loss of kidney function. Here, we characterised the effect of lisinopril, a standard ACE inhibitor, on kidney histopathology, renal biochemical markers, and kidney function in 5/6 Nx rats.

Subjects
Chronic kidney disease5/6 nephrectomy (Nx) ratAngiotensin converting enzyme (ACE)RatBlood biochemistryGlomerular filtration rate (GFR)Histopathology scoreImage analysisImmunohistochemistry (IHC)Kidney morphometryLisinopril

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