Effects of ALT-801, a GLP-1 and glucagon receptor dual agonist, in a translational mouse model of non-alcoholic steatohepatitis
Scientific Reports 12(1):6666, 2022
New insights into disease progression and human translatability of the GAN DIO-NASH mouse
Join preclinical NASH experts Michael Feigh and Henrik Björk Hansen in a scientist-to-scientist talk about the latest research discoveries and advances within human translational models of non-alcoholic steatohepatitis (NASH).
Nephroprotective effects of semaglutide in a preclinical model of hypertensive diabetic kidney disease
In this webinar, Gubra’s experts on preclinical DKD models, Principal Scientists Mette Østergaard and Henrik Björk Hansen, will discuss the effects of semaglutide on renal functional, histological and gene expression markers of advanced DKD in the db/db UNx-ReninAAV mouse.
Preclinical drug discovery in NASH – Narrowing the translational gap
In this webinar Principal Scientist at Gubra Henrik Björk Hansen discusses strategies to improve clinical translatability of preclinical models of NASH. The webinar introduces a diet-induced obese and biopsy-confirmed rodent model of NASH with progressive development of fibrosis and hepatocellular carcinoma, that recapitulates…
Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH
Clinical and Translational Science 15(5):1167-1186, 2022
Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease
American Journal of Physiology-Renal Physiology 321(2):F149-F161, 2021
Empagliflozin improves metabolic and hepatic outcomes in a non-diabetic obese biopsy-proven mouse model of advanced NASH
International Journal of Molecular Sciences 22:6332, 2021
Activation of thyroid hormone receptor-β improved disease activity and metabolism independent of body weight in a mouse model of non-alcoholic steatohepatitis and fibrosis
British Journal of Pharmacology 178(12):2412-2423, 2021