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Preclinical drug discovery in NASH – Narrowing the translational gap

In this webinar Principal Scientist at Gubra Henrik Björk Hansen discusses strategies to improve clinical translatability of preclinical models of NASH. The webinar introduces a diet-induced obese and biopsy-confirmed rodent model of NASH with progressive development of fibrosis and hepatocellular carcinoma, that recapitulates the wide spectrum of the human condition.

GAN DIO-NASH (GAN DIO-MASH) mouseHumanMouseBody weightBioinformaticsNon-alcoholic steatohepatitis/Metabolic dysfunction-associated steatohepatitis (NASH/MASH)GLP-1 receptorHistopathology scoreImage analysisImmunohistochemistryLiver biopsyLiver morphometryPPARNext-generation sequencingLanifibranorRNA sequencingSemaglutide

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