Cro services in
Lung (IPF)
Accelerate your drug development by exploring clinical pulmonary function endpoints and histopathological readouts in our BLEO-IPF mouse models. We apply clinically relevant endpoints to ensure model translatability and the understanding of drug mode-of-action.
Why Gubra?
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In-depth validated mouse models of IPF
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Spirometry-confirmed lung dysfunction
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Whole body plethysmography-validated disease stratification at baseline
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Automated AI-based histopathological scoring
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Profile compounds using clinical trial endpoints
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Tailored study design and rapid initiation
Asbjørn Graver Petersen
Senior Scientist, Scientific Sales
Reach out to our experts to learn how we can move your IPF drug pipeline forward
Advance your study in
spirometry-confirmed IPF models
We offer bleomycin-induced IPF mouse models with hallmarks of lung dysfunction confirmed by spirometry and whole body plethysmography. Our advanced study design allows for therapeutic intervention assessing anti-fibrotic efficacy.
Main Offerings
Lung function testing
Spirometry & Whole body plethysmography
Biochemical assessment
Plasma, Lung & BALF
Histopathological
Ashcroft scoring
Quantitative histology
Inflammation & fibrosis
Lung transcriptomic profile
advanced bleomycin models
Idiopathic Pulmonary Fibrosis (IPF) Models
Single BLEO-IPF mouse
- Mature-aged C57BL/6J mice on chow diet
- Single dose bleomycin induction
- Study period for 4 weeks post-bleomycin
- Whole body plethysmography & spirometry-confirmed lung dysfunction
- AI-based Ashcroft histopathological scoring
- Quantitative lung histology & transcriptomics
- Validated using TGFbeta/ALK5 inhibitor
Repetitive BLEO-IPF mouse
- Mature-aged C57BL/6J mice on chow diet
- Repetitive bleomycin lead-in induction for 6 weeks
- Therapeutic intervention for 6-12 weeks
- Whole body plethysmography & spirometry-confirmed lung dysfunction
- AI-based Ashcroft histopathological scoring
- Quantitative lung histology & transcriptomics
Cloud-based data viewer
GubraView
Our cloud-based data viewer GubraView provides instant access to study data as it is uploaded, ensuring seamless monitoring throughout your study. With features for cross-group and cross-study comparisons, GubraView enables informed decision-making with statistical analyses. Accessible across multiple locations, GubraView empowers efficient and collaborative drug development for your whole team.
Related pages
For further information
Contact us
Gubra
Hørsholm Kongevej 11B
2970 Hørsholm
Denmark
+45 3152 2650