Background & aim: Central regulation of appetite and satiety engages neuronal populations distributed across the brain. The identification of novel drug targets, development of anti-obesity therapeutics, and validation of their mode of action benefit from whole-brain imaging. Light-sheet fluorescence…
Background & aim: Neurodegenerative diseases are characterized by complex, large-scale structural and cellular alterations across the brain. Understanding these changes requires comprehensive, whole-brain analysis at high spatial resolution. Three-dimensional light sheet fluorescence microscopy (3D LSFM) enables rapid imaging of intact…
Background & aim: Progressive spreading of pathological alpha‑synuclein (αSyn) aggregates in the brain drives the degeneration of tyrosine hydroxylase (TH)-positive dopaminergic neurons in Parkinson’s disease (PD). Development of disease-modifying therapies has been hampered by the lack of techniques that can…
Speaker Urmas Roostalu Urmas is department manager for 3D Imaging and work in his team is focused on high throughput sample preparation and microscopy of proteins, mRNAs, and pharmacological compounds in whole organs. He has PhD in molecular biology and…
In this webinar, principal scientist and biologist Jacob Hecksher-Sørensen talks about the basic principles of 3D imaging, how to visualize and quantify intensities and cells in the whole brain. Finally, he talks about how this can be applied to large study groups.
