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Poster

Whole-brain 3D quantification of alpha-synuclein spreading in a mouse model of Parkinson’s disease

Background & Aim:

Progressive spreading of α-synuclein (αSyn) in combination with changes in the dopaminergic system constitute histopathological hallmarks of Parkinson’s disease (PD). While existing preclinical models often recapitulate advanced stages of PD, we here applied 3D whole-brain imaging to provide a combined spatiotemporal map of changes in αSyn aggregate architecture and tyrosine hydroxylase (TH) positive cell populations over the course of synucleinopathy in the αSyn pre-formed fibril (PFF) mouse model of earlystage PD.

Subjects
3D imagingAlpha-synucleinMouseParkinson's disease modelsBioinformaticsParkinson's diseaseImage analysisLight sheet fluorescence microscopy (LSFM)

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