Digital brain maps and virtual neuroscience. An emerging role for light sheet fluorescence microscopy in drug development
Frontiers in Neuroscience 16:866884, 2022
Nephroprotective effects of semaglutide in a preclinical model of hypertensive diabetic kidney disease
In this webinar, Gubra’s experts on preclinical DKD models, Principal Scientists Mette Østergaard and Henrik Björk Hansen, will discuss the effects of semaglutide on renal functional, histological and gene expression markers of advanced DKD in the db/db UNx-ReninAAV mouse.
Preclinical drug discovery in NASH – Narrowing the translational gap
In this webinar Principal Scientist at Gubra Henrik Björk Hansen discusses strategies to improve clinical translatability of preclinical models of NASH. The webinar introduces a diet-induced obese and biopsy-confirmed rodent model of NASH with progressive development of fibrosis and hepatocellular carcinoma, that recapitulates…
Lost in translation – how to improve the translatability of rodent models of diabetic kidney disease
Senior scientist Mette Viberg Østergaard introduces to the challenges of using current rodent models of diabetic kidney disease in drug discovery and development. Mette then presents an example of how translatability may be improved in a model of diabetic kidney disease in…
Imaging diabetes using light sheet microscopy
In this webinar, principal scientist and biologist Jacob Hecksher-Sørensen talks about how to label the beta cells and image the whole pancreas, how to quantify the beta cell volume in mouse models of Type 1 and Type 2 diabetes, and lastly, Jacob…
Whole brain imaging using light sheet microscopy
In this webinar, principal scientist and biologist Jacob Hecksher-Sørensen talks about the basic principles of 3D imaging, how to visualize and quantify intensities and cells in the whole brain. Finally, he talks about how this can be applied to large study groups.
Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH
Clinical and Translational Science 15(5):1167-1186, 2022