Whole-brain neuronal activity mapping

Whole-Brain c-Fos Imaging for Neuronal Activity Exploration

Gubra provides preclinical c-Fos imaging using automated whole-brain light-sheet fluorescence microscopy, enabling rapid turnaround times. Combine c-Fos imaging with customized in vivo pharmacology studies at Gubra or ship your samples to us for imaging.

What is c-Fos?

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Study the whole brain
instead of sections

Using fluorescence light sheet microscopy and tissue clearing, we scan whole rodent brains at single-cell resolution to capture total c-Fos distribution, enabling a deeper understanding of your compound.

Detailed data reporting

Our c-Fos Analysis Approach

Gubra’s expertise in whole brain imaging and AI-based image analysis provides accurate quantification of whole mouse and rat brain c-Fos signal.

Results are delivered as a comprehensive, publication-ready report designed to support internal decision-making, regulatory documentation, and external communication.

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Comprehensive brain-wide analysis delivered as publication-ready report

Our c-Fos pipeline provides:

Increased confidence in mechanism-of-action interpretation with clearer resolution and signal detection
Easy to interpret group comparisons
Faster access to decision-ready results
Regional insights at your fingertips with an interactive brain viewer

From In Vivo Studies to IND Submission

Accelerate your preclinical neuroscience programs towards IND filing

Gubra has vast experience in working with pharmaceutical and biotechnology companies to advance their preclinical programs efficiently and confidently. We support you at every stage, from strategic study design and in vivo execution to IND reporting.

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Complete data analysis from raw data to full interpretation

Statistically compare brain-wide c-Fos expression levels across your experimental groups at the voxel level, highlighting regions of upregulation and downregulation.

With our proprietary mouse brain atlas, compare neuronal activation across brain regions to get a comprehensive overview and uncover hidden patterns.

Gain a broader view of your compound’s mode of action using our library of brain activation patterns for reference drugs and proprietary data analytics. Leverage established comparator profiles to assess the similarity of your test compound, strengthening translational interpretation and disease-relevant decision-making. Explore functional associations of activated brain regions.

Contact us to discuss how enhanced whole brain c-Fos imaging can accelerate your preclinical drug discovery projects.

Learn about other ways we use whole brain imaging.

Contact us

Gubra

Hørsholm Kongevej 11B
2970 Hørsholm
Denmark

+45 3152 2650