Elucidating the potential benefit of pump-delivered subcutaneous GLP-1R agonist: an exploratory study in the diet-induced obese mouse
Background & aim: Subcutaneous pump delivery of the GLP1-receptor-agonist exenatide reduced body weight and improved glycemia in the DIO mouse. Basal-bolus administration conferred advantage over basal alone. This mode of incretin-based therapy offers an alternative to conventional intermittent dosing and…
Mucosal transcriptomic landscape along the small and large intestines in individuals with and without type 2 diabetes
Background & aim: A detailed mapping of functional differences among intestinal regions in healthy individuals remains incomplete. Identifying regional alterations in individuals with type 2 diabetes (T2D) could enhance our understanding of disease-related intestinal changes. Aim: To characterise the transcriptomic…
GIP affects hepatic fat and brown adipose tissue thermogenesis, but not white adipose tissue transcriptome in T1D
Journal of Clinical Endocrinology and Metabolism 107(12):3261-3274, 2022
LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men
Cell Reports Medicine 3(4):100582, 2022
Imaging diabetes using light sheet microscopy
In this webinar, principal scientist and biologist Jacob Hecksher-Sørensen talks about how to label the beta cells and image the whole pancreas, how to quantify the beta cell volume in mouse models of Type 1 and Type 2 diabetes, and lastly, Jacob…