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Comparative anti-fibrotic efficacy of resmetirom, semaglutide, tirzepatide and efruxifermin in the GAN diet-induced obese and biopsy-confirmed mouse model of MASH

  • Allison Butt

Background & aim: Resmetirom (RES, THR-βR agonist) has recently been FDA-approved for the treatment of metabolic dysfunction-associated steatohepatitis (MASH). Other drug concepts are in late-stage clinical development for MASH, including semaglutide (SEMA, GLP1R agonist), tirzepatide (TZP, GLP1R-GIPR co-agonist) and efruxifermin…

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Additive hepatoprotective effects of semaglutide and resmetirom combination therapy in the GAN diet-induced obese and biopsy-confirmed mouse model of MASH

  • Henrik

Background & Aim: Resmetirom (THR-β receptor agonist) has recently been approved for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) and semaglutide (GLP-1R agonist) is in late-stage clinical development for treatment of MASH. The present study aimed to characterize metabolic, biochemical,…

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