Background & aim: Central regulation of appetite and satiety engages neuronal populations distributed across the brain. The identification of novel drug targets, development of anti-obesity therapeutics, and validation of their mode of action benefit from whole-brain imaging. Light-sheet fluorescence…
Background & aim: Neurodegenerative diseases are characterized by complex, large-scale structural and cellular alterations across the brain. Understanding these changes requires comprehensive, whole-brain analysis at high spatial resolution. Three-dimensional light sheet fluorescence microscopy (3D LSFM) enables rapid imaging of intact…
Background & aim: Nutrient-stimulated gut hormone peptide YY3e36 (PYY3e36) selectively activates the neuropeptide Y2 receptor (NPY2R) and reduces energy intake in humans. We describe the discovery and pharmacology of the long-acting NPY2R agonist BI 1820237 and its potential bodyweight-lowering efficacy…
Speaker Urmas Roostalu Urmas is department manager for 3D Imaging and work in his team is focused on high throughput sample preparation and microscopy of proteins, mRNAs, and pharmacological compounds in whole organs. He has PhD in molecular biology and…
In this webinar, Gubra Scientist and imaging specialist Jacob Hecksher-Sørensen introduces to our interactive brain browser Gubra 3D Explorer. With this tool, you can explore individual brain regions of interest, display quantitative c-Fos data and filter for regions with statistically significant response to…
