Publication

Aberrant basement membrane production by HSCs in MASLD is attenuated by the bile acid analog INT-767

Hepatology Communications 25;8(12):e0574, 2024. Ramachandran P, Brice M, Sutherland EF, Hoy AM, Papachristoforou E, Jia L, Turner F, Kendall TJ, Marwick JA, Carragher NO, Oró D, Feigh M, Leeming DJ, Nielsen MJ, Karsdal MA, Hartmann N, Erickson M, Adorini L, Roth JD, Fallowfield JA.

Subjects

Mouse AMLN ob/ob-MASH mouse Body weight Metabolic dysfunction-associated steatohepatitis Histopathology score Image analysis Immunohistochemistry (IHC)Liver biopsy Liver morphometry

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INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

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