Publications

Publications

Tap into Gubra’s vast production of publications and posters to get the latest knowledge and insights within our focus areas: diabetes, obesity, NASH and gastrointestinal diseases.

Disease/target

Methodologies

Model/species

Chemical Strategies for Half-life Extension of Biopharmaceuticals: Lipidation and its Alternatives

Read more...

Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson’s Disease

Read more...

Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2

Read more...

The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion

Read more...

The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

Read more...

Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

Read more...

The brainstem preproglucagon system in a non-human primate (Macaca mulatta)

Read more...

Laser capture microdissection and quantitative-PCR analysis

Read more...

Liraglutide: short-lived effect on gastric emptying - long lasting effects on body weight

Read more...

The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis

Read more...

Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helixvariants of PYY3-36

Read more...

Peptide release, side-chain deprotection, work-up, and isolation

Read more...

Instruments for automated peptide synthesis

Read more...

The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat

Read more...

The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat

Read more...

Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis

Read more...

Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake

Read more...

The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats

Read more...

Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes

Read more...

The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathyhttps://www.ncbi.nlm.nih.gov/pubmed/26746341

Read more...

Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs

Read more...

Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor  agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson’s disease

Read more...

Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates

Read more...

Half-Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation

Read more...

Neoglycolipids for prolonging the effects of peptides: Self-assembling glucagon-like peptide 1 analogues with albumin binding properties and potent in vivo efficacy

Read more...

Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia

Read more...

Neurturin and a GLP-1 analogue act synergistically to alleviate diabetes in Zucker diabetic fatty rats

Read more...

Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model

Read more...

A hydrogel-microsphere drug delivery system that supports once-monthly administration of a GLP-1 receptor agonist

Read more...

Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues

Read more...

GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

Read more...

Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control

Read more...

Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

Read more...

Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice

Read more...

INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Read more...

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Read more...

Body-weight lowering agents and their comparative metabolic and hepatic effects in obese mouse models of non-alcoholic fatty liver disease and steatohepatitis (Gubra poster)

Read more...

In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes (European Journal of Pharmacology)

Read more...

Mouse models of nonalcoholic steatohepatitis in preclinical drug development (Drug Discovery Today)

Read more...

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice (Molecular Metabolism)

Read more...

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease (PLoS One)

Read more...

Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy (World Journal of Hepatology)

Read more...

The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice (Journal of Diabetes Research)

Read more...

Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass (Molecular Metabolism)

Read more...

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents ((PLoS One))

Read more...

Neuromedin U inhibits food intake partly by inhibiting gastric emptying (Peptides)

Read more...

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease (Journal of Alzheimer’s Disease)

Read more...

Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain (Endocrinology)

Read more...

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss (The Journal of Clinical Investigation )

Read more...

The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat (The Journal of Pharmacology and Experimental Therapeutics)

Read more...

The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice (The Journal of Pharmacology and Experimental Therapeutics)

Read more...

Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion (PLoS One)

Read more...

Characterisation of age-dependent beta cell dynamics in the male db/db mice (PLoS One)

Read more...

Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats (PLoS One)

Read more...

Novel insight into the distribution of L-cells in the rat intestinal tract (American Journal of Translational Research)

Read more...

The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice (Journal of Endocrinology)

Read more...

Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats (Acta Pharmacologica Sinica)

Read more...

Stereological assessment of pancreatic beta-cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta-cell function (Journal of Anatomy)

Read more...

Featured publications

INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Read more...

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Read more...

Mouse models of nonalcoholic steatohepatitis in preclinical drug development (Drug Discovery Today)

Read more...

Publications

Tap into Gubra’s vast production of publications and posters to get the latest knowledge and insights within our focus areas: diabetes, obesity, NASH and gastrointestinal diseases.

Featured publications

INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Read more...

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Read more...

Mouse models of nonalcoholic steatohepatitis in preclinical drug development (Drug Discovery Today)

Read more...

Disease/target

Methodologies

Model/species

Chemical Strategies for Half-life Extension of Biopharmaceuticals: Lipidation and its Alternatives

Read more...

Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson’s Disease

Read more...

Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2

Read more...

The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion

Read more...

The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

Read more...

Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

Read more...

The brainstem preproglucagon system in a non-human primate (Macaca mulatta)

Read more...

Laser capture microdissection and quantitative-PCR analysis

Read more...

Liraglutide: short-lived effect on gastric emptying - long lasting effects on body weight

Read more...

The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis

Read more...

Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helixvariants of PYY3-36

Read more...

Peptide release, side-chain deprotection, work-up, and isolation

Read more...

Instruments for automated peptide synthesis

Read more...

The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat

Read more...

The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat

Read more...

Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis

Read more...

Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake

Read more...

The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats

Read more...

Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes

Read more...

The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathyhttps://www.ncbi.nlm.nih.gov/pubmed/26746341

Read more...

Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs

Read more...

Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor  agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson’s disease

Read more...

Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates

Read more...

Half-Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation

Read more...

Neoglycolipids for prolonging the effects of peptides: Self-assembling glucagon-like peptide 1 analogues with albumin binding properties and potent in vivo efficacy

Read more...

Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia

Read more...

Neurturin and a GLP-1 analogue act synergistically to alleviate diabetes in Zucker diabetic fatty rats

Read more...

Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model

Read more...

A hydrogel-microsphere drug delivery system that supports once-monthly administration of a GLP-1 receptor agonist

Read more...

Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues

Read more...

GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

Read more...

Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control

Read more...

Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

Read more...

Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice

Read more...

INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Read more...

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Read more...

Body-weight lowering agents and their comparative metabolic and hepatic effects in obese mouse models of non-alcoholic fatty liver disease and steatohepatitis (Gubra poster)

Read more...

In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes (European Journal of Pharmacology)

Read more...

Mouse models of nonalcoholic steatohepatitis in preclinical drug development (Drug Discovery Today)

Read more...

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice (Molecular Metabolism)

Read more...

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease (PLoS One)

Read more...

Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy (World Journal of Hepatology)

Read more...

The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice (Journal of Diabetes Research)

Read more...

Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass (Molecular Metabolism)

Read more...

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents ((PLoS One))

Read more...

Neuromedin U inhibits food intake partly by inhibiting gastric emptying (Peptides)

Read more...

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease (Journal of Alzheimer’s Disease)

Read more...

Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain (Endocrinology)

Read more...

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss (The Journal of Clinical Investigation )

Read more...

The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat (The Journal of Pharmacology and Experimental Therapeutics)

Read more...

The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice (The Journal of Pharmacology and Experimental Therapeutics)

Read more...

Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion (PLoS One)

Read more...

Characterisation of age-dependent beta cell dynamics in the male db/db mice (PLoS One)

Read more...

Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats (PLoS One)

Read more...

Novel insight into the distribution of L-cells in the rat intestinal tract (American Journal of Translational Research)

Read more...

The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice (Journal of Endocrinology)

Read more...

Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats (Acta Pharmacologica Sinica)

Read more...

Stereological assessment of pancreatic beta-cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta-cell function (Journal of Anatomy)

Read more...

Gubra

Hørsholm Kongevej 11B
2970 Hørsholm
Denmark

info@gubra.dk
+45 3152 ­2650