Publications

Tap into Gubra’s vast production of publications and posters to get the latest knowledge and insights within our focus areas: diabetes, obesity, NASH and gastrointestinal diseases.

Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis

Kirstine S. Tølbøl, Birgit Stierstorfer, Jörg F. Rippmann, Sanne S. Veidal, Kristoffer T. G. Rigbolt, Tanja Schönberger, Matthew P. Gillum, Henrik H. Hansen, Niels Vrang, Jacob Jelsing, Michael Feigh, Andre Broermann.

Publications

Publications

Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis

Chemical Strategies for Half-life Extension of Biopharmaceuticals: Lipidation and its Alternatives

Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson’s Disease

Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2

The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion

The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

The brainstem preproglucagon system in a non-human primate (Macaca mulatta)

Laser capture microdissection and quantitative-PCR analysis

Liraglutide: short-lived effect on gastric emptying - long lasting effects on body weight

The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis

Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helixvariants of PYY3-36

Peptide release, side-chain deprotection, work-up, and isolation

Instruments for automated peptide synthesis

The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat

The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat

Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis

Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake

The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats

Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes

The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathyhttps://www.ncbi.nlm.nih.gov/pubmed/26746341

Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs

Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson’s disease

Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates

Half-Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation

Neoglycolipids for prolonging the effects of peptides: Self-assembling glucagon-like peptide 1 analogues with albumin binding properties and potent in vivo efficacy

Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia

Neurturin and a GLP-1 analogue act synergistically to alleviate diabetes in Zucker diabetic fatty rats

Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model

A hydrogel-microsphere drug delivery system that supports once-monthly administration of a GLP-1 receptor agonist

Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues

GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control

Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice

INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes (European Journal of Pharmacology)

Mouse models of nonalcoholic steatohepatitis in preclinical drug development (Drug Discovery Today)

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice (Molecular Metabolism)

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease (PLoS One)

Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy (World Journal of Hepatology)

The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice (Journal of Diabetes Research)

Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass (Molecular Metabolism)

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents ((PLoS One))

Neuromedin U inhibits food intake partly by inhibiting gastric emptying (Peptides)

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease (Journal of Alzheimer’s Disease)

Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain (Endocrinology)

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss (The Journal of Clinical Investigation )

The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat (The Journal of Pharmacology and Experimental Therapeutics)

The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice (The Journal of Pharmacology and Experimental Therapeutics)

Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion (PLoS One)

Characterisation of age-dependent beta cell dynamics in the male db/db mice (PLoS One)

Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats (PLoS One)

Novel insight into the distribution of L-cells in the rat intestinal tract (American Journal of Translational Research)

The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice (Journal of Endocrinology)

Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats (Acta Pharmacologica Sinica)

Stereological assessment of pancreatic beta-cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta-cell function (Journal of Anatomy)

Featured publications

INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Mouse models of nonalcoholic steatohepatitis in preclinical drug development (Drug Discovery Today)

Publications

Featured publications

INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Mouse models of nonalcoholic steatohepatitis in preclinical drug development (Drug Discovery Today)

Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis

Chemical Strategies for Half-life Extension of Biopharmaceuticals: Lipidation and its Alternatives

Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson’s Disease

Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2

The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion

The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

The brainstem preproglucagon system in a non-human primate (Macaca mulatta)

Laser capture microdissection and quantitative-PCR analysis

Liraglutide: short-lived effect on gastric emptying - long lasting effects on body weight

The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis