Publications

Publications

Tap into Gubra’s vast production of publications and posters to get the latest knowledge and insights within our focus areas: diabetes, obesity, NASH and gastrointestinal diseases.

Disease

Target

Compounds

Species

Methodologies

Model

GIP affects hepatic fat and brown adipose tissue thermogenesis, but not white adipose tissue transcriptome in T1D

Journal of Clinical Endocrinology and Metabolism [online ahead of print]
Read more...

Nuclear morphology is a deep learning biomarker of cellular senescence

Nature Aging 2:742–755, 2022
Read more...

Nephroprotective effects of semaglutide as mono- and combination treatment with lisinopril in a mouse model of hypertension-accelerated diabetic kidney disease

Biomedicines 10(7):1661, 2022
Read more...

Structurally-engineered fatty acid 1024 (SEFA-1024) improves diet-induced obesity, insulin resistance, and fatty liver disease

Lipids 57(4-5):241-255, 2022
Read more...

LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men

Cell Reports Medicine 3(4):100582, 2022
Read more...

Effects of ALT-801, a GLP-1 and glucagon receptor dual agonist, in a translational mouse model of non-alcoholic steatohepatitis

Scientific Reports 12(1):6666, 2022
Read more...

Digital brain maps and virtual neuroscience. An emerging role for light sheet fluorescence microscopy in drug development

Frontiers in Neuroscience 16:866884, 2022
Read more...

Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH

Clinical and Translational Science 15(5):1167-1186, 2022
Read more...

Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect

Scientific Reports 12:1696, 2022
Read more...

Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese-diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries

Molecular Metabolism 55:101392, 2021
Read more...

Integrative transcriptomic profiling of a mouse model of hypertension-accelerated diabetic kidney disease

Disease Models & Mechanisms 14(10): dmm049086, 2021
Read more...

Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease

American Journal of Physiology-Renal Physiology 321(2):F149-F161, 2021
Read more...

Empagliflozin improves metabolic and hepatic outcomes in a non-diabetic obese biopsy-proven mouse model of advanced NASH

International Journal of Molecular Sciences 22:6332, 2021
Read more...

Comparative study of voxel-based statistical analysis methods for fluorescently labelled and light sheet imaged whole-brain samples

Proceedings of the 2021 IEEE 18th International Symposium on Biomedical Imaging, p. 1433-1437
Read more...

Whole-brain mapping of amylin-induced neuronal activity in receptor activity–modifying protein (RAMP) 1/3 knockout mice

European Journal of Neuroscience 54:4154-4166, 2021
Read more...

Characterization of combined linagliptin and Y2R agonist treatment in diet-induced obese mice 

Scientific Reports 11:8060, 2021
Read more...

Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism

PLoS One 16(3):e0249239, 2021
Read more...

Elafibranor and liraglutide improve differentially liver health and metabolism in a mouse model of non-alcoholic steatohepatitis

Liver International 41(8):1853-1866, 2021
Read more...

A genetic map of the mouse dorsal vagal complex and its role in obesity

Nature Metabolism 3(4):530-545, 2021
Read more...

Effect of captopril on post-infarction remodelling visualized by light sheet microscopy and echocardiography

Scientific Reports 11(1):5241, 2021
Read more...

Activation of thyroid hormone receptor-β improved disease activity and metabolism independent of body weight in a mouse model of non-alcoholic steatohepatitis and fibrosis

British Journal of Pharmacology 178(12):2412-2423, 2021
Read more...

Interferon lambda 4 genotype and pathway in alcoholic hepatitis

Scandinavian Journal of Gastroenterology 56(3):304-311, 2021
Read more...

Whole-brain activation signatures of weight-lowering drugs

Molecular Metabolism 101171, 2021
Read more...

Deep learning reveals 3D atherosclerotic plaque distribution and composition 

Scientific Reports 10(1):21523, 2020
Read more...

Transcriptomic changes in pancreatic islets, adipose and liver after Roux-en-Y gastric bypass in a diet-induced obese rat model

Peptides 136:170467, 2020
Read more...

An aldehyde responsive, cleavable linker for glucose responsive insulins

Chemistry 27:1-12, 2021
Read more...

Characterization of local gut microbiome and intestinal transcriptome responses to rosiglitazone treatment in db/db mice

Biomedicine & Pharmacotherapy 133:110966
Read more...

3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II

Disease Models & Mechanisms 13(12):dmm045351, 2020
Read more...

Gut mucosal gene expression and metabolic changes after Roux-en-Y gastric bypass surgery

Obesity 28(11): 2163-2174, 2020
Read more...

Identification and metabolic profiling of a novel human gut-derived LEAP2 fragment

Journal of Clinical Endocrinology and Metabolism 106(2):e966-e981, 2021
Read more...

An optimized mouse brain atlas for automated mapping and quantification of neuronal activity using iDISCO+ and light sheet fluorescence microscopy

Neuroinformatics [online ahead of print]
Read more...

Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy

Scientific Reports 10:16130, 2020
Read more...

Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative

Liver International 40:2860-2876, 2020
Read more...

Low interleukin-22 binding protein is associated with high mortality in alcoholic hepatitis and modulates interleukin-22 receptor expression

Clinical and Translational Gastroenterology 11(8):e00197
Read more...

Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

BMC Gastroenterology 20:210, 2020
Read more...

The selective peroxisome proliferator‐activated receptor gamma modulator CHS‐131 improves liver histopathology and metabolism in a mouse model of obesity and nonalcoholic steatohepatitis

Hepatology Communications 4(9):1302-1315, 2020
Read more...

Automated image analyses of glomerular hypertrophy in a mouse model of diabetic nephropathy

Kidney360 1(6): 469-479, 2020
Read more...

Whole-brain 3D imaging for quantification of drug targets and treatment effects in mouse models of neurodegenerative diseases

Neural Regeneration Research 15(12):2255-2257, 2020
Read more...

Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis

Nature Metabolism 2(5):413–431, 2020
Read more...

Activation of adenosine monophosphate-activated protein kinase reduces the onset of diet-induced hepatocellular carcinoma in mice

Hepatology Communications 4(7):1056-1072, 2020
Read more...

Rodent models of diabetic kidney disease: human translatability and preclinical validity

Drug Discovery Today 26(1):200-217, 2021
Read more...

Incretin combination therapy for the treatment of non-alcoholic steatohepatitis

Diabetes, Obesity and Metabolism 22(8):1328-1338, 2020
Read more...

Glucagon resistance at the level of amino acid turnover in obese subjects with hepatic steatosis

Diabetes 69(6):1090-1099, 2020
Read more...

Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis

Scientific Reports 10(1):1148, 2020
Read more...

Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH

BMC Gastroenterology 19(1):228, 2019
Read more...

Impact of sex on diabetic nephropathy and the renal transcriptome in UNx db/db C57BLKS mice

Physiology Reports 7(24):e14333, 2019
Read more...

Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease

Disease Models & Mechanisms 12(11):dmm042200, 2019
Read more...

The dorsomedial hypothalamus and nucleus of the solitary tract as key regulators in a rat model of chronic obesity

Brain Research 1727:146538, 2020
Read more...

Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss

Scientific Reports 9(1):16161, 2019
Read more...

Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice

Scientific Reports 9(1):15582, 2019
Read more...

Mastiha (Pistacia Lentiscus) improves gut microbiota diversity, hepatic steatosis and disease activity in a biopsy-confirmed mouse model of advanced non-alcoholic steatohepatitis and fibrosis

Molecular Nutrition & Food Research 63(24):e1900927, 2019
Read more...

Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source

World Journal of Gastroenterology 25(33):4904-4920, 2019
Read more...

Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion

Liver International 39(11):2094-2101, 2019
Read more...

Half-Life extending modifications of peptide YY3-36 direct receptor-mediated internalization

Molecular Pharmaceutics 16(8):3665-3677, 2019
Read more...

Investigating intestinal glucagon after Roux-en-Y gastric bypass surgery

Journal of Clinical Endocrinology & Metabolism 104(12):6403-6416, 2019
Read more...

RhoA in tyrosine hydroxylase neurons regulates food intake and body weight via altered sensitivity to peripheral hormones

Journal of Neuroendocrinology 31(7):e12761, 2019
Read more...

Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH

Scientific Reports 9(1):9046, 2019
Read more...

The preprohormone expression profile of enteroendocrine cells following Roux-en-Y gastric bypass in rats

Peptides 118:170100, 2019
Read more...

Hepatic molecular characteristics of patients with varying degrees of nonalcoholic steatohepatitis compared to healthy normal weight individuals

American Journal of Physiology - Gastroenterology and Liver Physiology 316(4):G462-G472, 2019
Read more...

Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes

Journal of Translational Medicine 17:110, 2019
Read more...

Animal models of type 2 diabetes, obesity and nonalcoholic steatohepatitis – clinical translatability and applicability in preclinical drug development

In: Krentz A., Weyer C., Hompesch M. (eds) Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. Springer, Cham. pp 369-403, 2019
Read more...

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

Molecular Metabolism 21:36-50, 2019
Read more...

Bariatric surgery in patients with non-alcoholic fatty liver disease - from pathophysiology to clinical effects

World Journal of Hepatology 11(2):138-149, 2019
Read more...

Pancreatic β-cell rest replenishes insulin secretory capacity and attenuates diabetes in an extreme model of obese type 2 diabetes

Diabetes 68(1):131-140, 2019
Read more...

Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice

Biomedicine & Pharmacotherapy 109:167-173, 2019
Read more...

Molecular characterization of microvesicular and macrovesicular steatosis shows widespread differences in metabolic pathways

Lipids 54(1):109-115, 2019
Read more...

Disease progression and pharmacological intervention in a nutrient-deficient rat model of nonalcoholic steatohepatitis

Digestive Diseases and Sciences 64(5):1238-1256, 2019
Read more...

Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice

Physiology and Behavior 192:72-81, 2018
Read more...

Chemical Strategies for Half-life Extension of Biopharmaceuticals: Lipidation and its Alternatives

ACS Medicinal Chemistry Letters 9(7):577-580, 2018
Read more...

Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control

Peptides 101:32–43, 2018
Read more...

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

World Journal of Gastroenterology 24(2):195–210, 2018
Read more...

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis

World Journal of Gastroenterology 24(2):179–194, 2018
Read more...

Application of the physical disector principle for quantification of dopaminergic neuronal loss in a rat 6-hydroxydopamine nigral lesion model of Parkinson’s disease

Frontiers in Neuroanatomy 11:109, 2017
Read more...

GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

Journal of Peptide Science 23(12):845–854, 2017
Read more...

In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes

European Journal of Pharmacology 815:181–189, 2017
Read more...

Mouse models of nonalcoholic steatohepatitis in preclinical drug development

Drug Discovery Today 22(11):1707–1718, 2017
Read more...

Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

Diabetologia 61(2):284–294, 2017
Read more...

Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues

Journal of Medicinal Chemistry 60(17):7434–7446, 2017
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A hydrogel-microsphere drug delivery system that supports once-monthly administration of a GLP-1 receptor agonist

ACS Chemical Biology 12(8):2107–2116, 2017
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Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia

Kidney International 92(1):165–178, 2017
Read more...

Neurturin and a GLP-1 analogue act synergistically to alleviate diabetes in Zucker diabetic fatty rats

Diabetes 66(7):2007–2018, 2017
Read more...

Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model

Brain Research 1665:22–35, 2017
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The endogenous preproglucagon system is not essential for gut growth homeostasis in mice

Molecular Metabolism 6(7):681–692, 2017
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Neoglycolipids for prolonging the effects of peptides: Self-assembling glucagon-like peptide 1 analogues with albumin binding properties and potent in vivo efficacy

Molecular Pharmacology 14(1):193–205, 2017
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Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates

Diabetes Obesity and Metabolism 18(12):1176–1190, 2016
Read more...

Half-Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation

ChemMedChem 11(22):2474–2495, 2016
Read more...

Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson’s disease

Brain Research 1646:354–365, 2016
Read more...

Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery

Endocrinology 157(9):3482–92, 2016
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Long-term treatment with liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has no effect on β-amyloid plaque load in two transgenic APP/PS1 mouse models of Alzheimer’s disease

PLOS One 11(7):e0158205, 2016
Read more...

Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy

World Journal of Hepatology 8(16):673-684, 2016
Read more...

The IL-1β receptor antagonist SER140 postpones the onset of diabetes in female nonobese diabetic mice

Journal of Diabetes Research 2016:7484601, 2016
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Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs

American Journal of Physiology - Gastrointestinal and Liver Physiology 310(8):G550-560, 2016
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The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

Brain Research 1634:158–170, 2016
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Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass

Molecular Metabolism 5(4):296-304, 2016
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Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes

Diabetologia 58(10):2254–8, 2015
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A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents

PLOS One 10(8):e0135634, 2015
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Neuromedin U inhibits food intake partly by inhibiting gastric emptying

Peptides 69:56–65, 2015
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The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats

Peptides 69:47–55, 2015
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The GLP-1 receptor agonist liraglutide improves memory function and increases hippocampal CA1 neuronal numbers in a senescence-accelerated mouse model of Alzheimer's disease

Journal of Alzheimers Disease 46(4):877–88, 2015
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Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis

Diabetes 64(3):1046–56, 2015
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Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake

Journal of Peptide Science 21(2):85–94, 2015
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Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) Brain

Endocrinology 156(1):255–267, 2015
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Post-surgical effects of Roux-en-Y gastric bypass on glucose homeostasis, intestinal morphology and L-cells in obese Göttingen minipigs

Journal of Obesity and Bariatrics 1(1):8, 2015
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The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat

European Journal of Pharmacology 741:254-263, 2014
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The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

Journal of Clinical Investigation 124(10):4473-4488, 2014
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The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat

The Journal of Pharmacology and Experimental Therapeutics 350(3):657–664, 2014
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The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice

The Journal of Pharmacology and Experimental Therapeutics 350(2):353–360, 2014
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Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion

PLOS One 9(2):e88227, 2014
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The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat

Regulatory Peptides 189:31–9, 2014
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Characterisation of age-dependent beta cell dynamics in the male db/db mice

PLOS One 8(12):e82813, 2013
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Instruments for automated peptide synthesis

In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:215–24, 2013
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Peptide release, side-chain deprotection, work-up, and isolation

In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:43–63, 2013
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Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats

PLOS One 8(6):e65696, 2013
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Novel insight into the distribution of L-cells in the rat intestinal tract

American Journal of Translational Research 5(3):347–58, 2013
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Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helixvariants of PYY3-36

Journal of Peptide Science 18(9):579-587, 2012
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The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice

Journal of Endocrinology 214(3):381–387, 2012
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The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis

American Journal of Physiolology - Endocrinology and Metabolism 303:E253-E264, 2012
Read more...

Liraglutide: short-lived effect on gastric emptying - long lasting effects on body weight

Diabetes Obesity & Metabolism 14(6):531–538, 2012
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Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats

Acta Pharmacologica Sinica 33:194–200, 2012
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Laser capture microdissection and quantitative-PCR analysis

In: Adalberto Merighi (ed.), Neuropeptides: Methods and Protocols, Methods in Molecular Biology 789:127–35, 2011
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The brainstem preproglucagon system in a non-human primate (Macaca mulatta)

Brain Research 1397:28–37, 2011
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Stereological assessment of pancreatic beta-cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta-cell function

Journal of Anatomy 217(5):624-630, 2010
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Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

Progress in Neurobiology 92(3):442–462, 2010
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The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

Obesity (Silver Spring) 18(7):1289–1296, 2010
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The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion

Neuroscience Letters 463(2):125–129, 2009
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Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2

Brain Research Bulletin 78:202–10, 2009
Read more...

Featured publications

Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease

American Journal of Physiology-Renal Physiology 321(2):F149-F161, 2021
Read more...

Whole-brain activation signatures of weight-lowering drugs

Molecular Metabolism 101171, 2021
Read more...

An aldehyde responsive, cleavable linker for glucose responsive insulins

Chemistry 27:1-12, 2021
Read more...

3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II

Disease Models & Mechanisms 13(12):dmm045351, 2020
Read more...

Identification and metabolic profiling of a novel human gut-derived LEAP2 fragment

Journal of Clinical Endocrinology and Metabolism 106(2):e966-e981, 2021
Read more...

Publications

Tap into Gubra’s vast production of publications and posters to get the latest knowledge and insights within our focus areas: diabetes, obesity, NASH and gastrointestinal diseases.

Featured publications

Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease

American Journal of Physiology-Renal Physiology 321(2):F149-F161, 2021
Read more...

Whole-brain activation signatures of weight-lowering drugs

Molecular Metabolism 101171, 2021
Read more...

An aldehyde responsive, cleavable linker for glucose responsive insulins

Chemistry 27:1-12, 2021
Read more...

3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II

Disease Models & Mechanisms 13(12):dmm045351, 2020
Read more...

Identification and metabolic profiling of a novel human gut-derived LEAP2 fragment

Journal of Clinical Endocrinology and Metabolism 106(2):e966-e981, 2021
Read more...

Disease

Target

Compounds

Species

Methodologies

Model

GIP affects hepatic fat and brown adipose tissue thermogenesis, but not white adipose tissue transcriptome in T1D

Journal of Clinical Endocrinology and Metabolism [online ahead of print]
Read more...

Nuclear morphology is a deep learning biomarker of cellular senescence

Nature Aging 2:742–755, 2022
Read more...

Nephroprotective effects of semaglutide as mono- and combination treatment with lisinopril in a mouse model of hypertension-accelerated diabetic kidney disease

Biomedicines 10(7):1661, 2022
Read more...

Structurally-engineered fatty acid 1024 (SEFA-1024) improves diet-induced obesity, insulin resistance, and fatty liver disease

Lipids 57(4-5):241-255, 2022
Read more...

LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men

Cell Reports Medicine 3(4):100582, 2022
Read more...

Effects of ALT-801, a GLP-1 and glucagon receptor dual agonist, in a translational mouse model of non-alcoholic steatohepatitis

Scientific Reports 12(1):6666, 2022
Read more...

Digital brain maps and virtual neuroscience. An emerging role for light sheet fluorescence microscopy in drug development

Frontiers in Neuroscience 16:866884, 2022
Read more...

Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH

Clinical and Translational Science 15(5):1167-1186, 2022
Read more...

Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect

Scientific Reports 12:1696, 2022
Read more...

Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese-diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries

Molecular Metabolism 55:101392, 2021
Read more...

Integrative transcriptomic profiling of a mouse model of hypertension-accelerated diabetic kidney disease

Disease Models & Mechanisms 14(10): dmm049086, 2021
Read more...

Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease

American Journal of Physiology-Renal Physiology 321(2):F149-F161, 2021
Read more...

Empagliflozin improves metabolic and hepatic outcomes in a non-diabetic obese biopsy-proven mouse model of advanced NASH

International Journal of Molecular Sciences 22:6332, 2021
Read more...

Comparative study of voxel-based statistical analysis methods for fluorescently labelled and light sheet imaged whole-brain samples

Proceedings of the 2021 IEEE 18th International Symposium on Biomedical Imaging, p. 1433-1437
Read more...

Whole-brain mapping of amylin-induced neuronal activity in receptor activity–modifying protein (RAMP) 1/3 knockout mice

European Journal of Neuroscience 54:4154-4166, 2021
Read more...

Characterization of combined linagliptin and Y2R agonist treatment in diet-induced obese mice 

Scientific Reports 11:8060, 2021
Read more...

Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism

PLoS One 16(3):e0249239, 2021
Read more...

Elafibranor and liraglutide improve differentially liver health and metabolism in a mouse model of non-alcoholic steatohepatitis

Liver International 41(8):1853-1866, 2021
Read more...

A genetic map of the mouse dorsal vagal complex and its role in obesity

Nature Metabolism 3(4):530-545, 2021
Read more...

Effect of captopril on post-infarction remodelling visualized by light sheet microscopy and echocardiography

Scientific Reports 11(1):5241, 2021
Read more...

Activation of thyroid hormone receptor-β improved disease activity and metabolism independent of body weight in a mouse model of non-alcoholic steatohepatitis and fibrosis

British Journal of Pharmacology 178(12):2412-2423, 2021
Read more...

Interferon lambda 4 genotype and pathway in alcoholic hepatitis

Scandinavian Journal of Gastroenterology 56(3):304-311, 2021
Read more...

Whole-brain activation signatures of weight-lowering drugs

Molecular Metabolism 101171, 2021
Read more...

Deep learning reveals 3D atherosclerotic plaque distribution and composition 

Scientific Reports 10(1):21523, 2020
Read more...

Transcriptomic changes in pancreatic islets, adipose and liver after Roux-en-Y gastric bypass in a diet-induced obese rat model

Peptides 136:170467, 2020
Read more...

An aldehyde responsive, cleavable linker for glucose responsive insulins

Chemistry 27:1-12, 2021
Read more...

Characterization of local gut microbiome and intestinal transcriptome responses to rosiglitazone treatment in db/db mice

Biomedicine & Pharmacotherapy 133:110966
Read more...

3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II

Disease Models & Mechanisms 13(12):dmm045351, 2020
Read more...

Gut mucosal gene expression and metabolic changes after Roux-en-Y gastric bypass surgery

Obesity 28(11): 2163-2174, 2020
Read more...

Identification and metabolic profiling of a novel human gut-derived LEAP2 fragment

Journal of Clinical Endocrinology and Metabolism 106(2):e966-e981, 2021
Read more...

An optimized mouse brain atlas for automated mapping and quantification of neuronal activity using iDISCO+ and light sheet fluorescence microscopy

Neuroinformatics [online ahead of print]
Read more...

Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy

Scientific Reports 10:16130, 2020
Read more...

Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative

Liver International 40:2860-2876, 2020
Read more...

Low interleukin-22 binding protein is associated with high mortality in alcoholic hepatitis and modulates interleukin-22 receptor expression

Clinical and Translational Gastroenterology 11(8):e00197
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Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

BMC Gastroenterology 20:210, 2020
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The selective peroxisome proliferator‐activated receptor gamma modulator CHS‐131 improves liver histopathology and metabolism in a mouse model of obesity and nonalcoholic steatohepatitis

Hepatology Communications 4(9):1302-1315, 2020
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Automated image analyses of glomerular hypertrophy in a mouse model of diabetic nephropathy

Kidney360 1(6): 469-479, 2020
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Whole-brain 3D imaging for quantification of drug targets and treatment effects in mouse models of neurodegenerative diseases

Neural Regeneration Research 15(12):2255-2257, 2020
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Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis

Nature Metabolism 2(5):413–431, 2020
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Activation of adenosine monophosphate-activated protein kinase reduces the onset of diet-induced hepatocellular carcinoma in mice

Hepatology Communications 4(7):1056-1072, 2020
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Rodent models of diabetic kidney disease: human translatability and preclinical validity

Drug Discovery Today 26(1):200-217, 2021
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Incretin combination therapy for the treatment of non-alcoholic steatohepatitis

Diabetes, Obesity and Metabolism 22(8):1328-1338, 2020
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Glucagon resistance at the level of amino acid turnover in obese subjects with hepatic steatosis

Diabetes 69(6):1090-1099, 2020
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Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis

Scientific Reports 10(1):1148, 2020
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Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH

BMC Gastroenterology 19(1):228, 2019
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Impact of sex on diabetic nephropathy and the renal transcriptome in UNx db/db C57BLKS mice

Physiology Reports 7(24):e14333, 2019
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Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease

Disease Models & Mechanisms 12(11):dmm042200, 2019
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The dorsomedial hypothalamus and nucleus of the solitary tract as key regulators in a rat model of chronic obesity

Brain Research 1727:146538, 2020
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Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss

Scientific Reports 9(1):16161, 2019
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Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice

Scientific Reports 9(1):15582, 2019
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Mastiha (Pistacia Lentiscus) improves gut microbiota diversity, hepatic steatosis and disease activity in a biopsy-confirmed mouse model of advanced non-alcoholic steatohepatitis and fibrosis

Molecular Nutrition & Food Research 63(24):e1900927, 2019
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Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source

World Journal of Gastroenterology 25(33):4904-4920, 2019
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Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion

Liver International 39(11):2094-2101, 2019
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Half-Life extending modifications of peptide YY3-36 direct receptor-mediated internalization

Molecular Pharmaceutics 16(8):3665-3677, 2019
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Investigating intestinal glucagon after Roux-en-Y gastric bypass surgery

Journal of Clinical Endocrinology & Metabolism 104(12):6403-6416, 2019
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RhoA in tyrosine hydroxylase neurons regulates food intake and body weight via altered sensitivity to peripheral hormones

Journal of Neuroendocrinology 31(7):e12761, 2019
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Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH

Scientific Reports 9(1):9046, 2019
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The preprohormone expression profile of enteroendocrine cells following Roux-en-Y gastric bypass in rats

Peptides 118:170100, 2019
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Hepatic molecular characteristics of patients with varying degrees of nonalcoholic steatohepatitis compared to healthy normal weight individuals

American Journal of Physiology - Gastroenterology and Liver Physiology 316(4):G462-G472, 2019
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Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes

Journal of Translational Medicine 17:110, 2019
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Animal models of type 2 diabetes, obesity and nonalcoholic steatohepatitis – clinical translatability and applicability in preclinical drug development

In: Krentz A., Weyer C., Hompesch M. (eds) Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. Springer, Cham. pp 369-403, 2019
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The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

Molecular Metabolism 21:36-50, 2019
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Bariatric surgery in patients with non-alcoholic fatty liver disease - from pathophysiology to clinical effects

World Journal of Hepatology 11(2):138-149, 2019
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Pancreatic β-cell rest replenishes insulin secretory capacity and attenuates diabetes in an extreme model of obese type 2 diabetes

Diabetes 68(1):131-140, 2019
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Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice

Biomedicine & Pharmacotherapy 109:167-173, 2019
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Molecular characterization of microvesicular and macrovesicular steatosis shows widespread differences in metabolic pathways

Lipids 54(1):109-115, 2019
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Disease progression and pharmacological intervention in a nutrient-deficient rat model of nonalcoholic steatohepatitis

Digestive Diseases and Sciences 64(5):1238-1256, 2019
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Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice

Physiology and Behavior 192:72-81, 2018
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Chemical Strategies for Half-life Extension of Biopharmaceuticals: Lipidation and its Alternatives

ACS Medicinal Chemistry Letters 9(7):577-580, 2018
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Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control

Peptides 101:32–43, 2018
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INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

World Journal of Gastroenterology 24(2):195–210, 2018
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Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis

World Journal of Gastroenterology 24(2):179–194, 2018
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Application of the physical disector principle for quantification of dopaminergic neuronal loss in a rat 6-hydroxydopamine nigral lesion model of Parkinson’s disease

Frontiers in Neuroanatomy 11:109, 2017
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GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

Journal of Peptide Science 23(12):845–854, 2017
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In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes

European Journal of Pharmacology 815:181–189, 2017
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Mouse models of nonalcoholic steatohepatitis in preclinical drug development

Drug Discovery Today 22(11):1707–1718, 2017
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Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

Diabetologia 61(2):284–294, 2017
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Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues

Journal of Medicinal Chemistry 60(17):7434–7446, 2017
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A hydrogel-microsphere drug delivery system that supports once-monthly administration of a GLP-1 receptor agonist

ACS Chemical Biology 12(8):2107–2116, 2017
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Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia

Kidney International 92(1):165–178, 2017
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Neurturin and a GLP-1 analogue act synergistically to alleviate diabetes in Zucker diabetic fatty rats

Diabetes 66(7):2007–2018, 2017
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Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model

Brain Research 1665:22–35, 2017
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The endogenous preproglucagon system is not essential for gut growth homeostasis in mice

Molecular Metabolism 6(7):681–692, 2017
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Neoglycolipids for prolonging the effects of peptides: Self-assembling glucagon-like peptide 1 analogues with albumin binding properties and potent in vivo efficacy

Molecular Pharmacology 14(1):193–205, 2017
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Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates

Diabetes Obesity and Metabolism 18(12):1176–1190, 2016
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Half-Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation

ChemMedChem 11(22):2474–2495, 2016
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Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson’s disease

Brain Research 1646:354–365, 2016
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Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery

Endocrinology 157(9):3482–92, 2016
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Long-term treatment with liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has no effect on β-amyloid plaque load in two transgenic APP/PS1 mouse models of Alzheimer’s disease

PLOS One 11(7):e0158205, 2016
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Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy

World Journal of Hepatology 8(16):673-684, 2016
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The IL-1β receptor antagonist SER140 postpones the onset of diabetes in female nonobese diabetic mice

Journal of Diabetes Research 2016:7484601, 2016
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Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs

American Journal of Physiology - Gastrointestinal and Liver Physiology 310(8):G550-560, 2016
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The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

Brain Research 1634:158–170, 2016
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Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass

Molecular Metabolism 5(4):296-304, 2016
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Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes

Diabetologia 58(10):2254–8, 2015
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A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents

PLOS One 10(8):e0135634, 2015
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Neuromedin U inhibits food intake partly by inhibiting gastric emptying

Peptides 69:56–65, 2015
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The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats

Peptides 69:47–55, 2015
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The GLP-1 receptor agonist liraglutide improves memory function and increases hippocampal CA1 neuronal numbers in a senescence-accelerated mouse model of Alzheimer's disease

Journal of Alzheimers Disease 46(4):877–88, 2015
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Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis

Diabetes 64(3):1046–56, 2015
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Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake

Journal of Peptide Science 21(2):85–94, 2015
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Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) Brain

Endocrinology 156(1):255–267, 2015
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Post-surgical effects of Roux-en-Y gastric bypass on glucose homeostasis, intestinal morphology and L-cells in obese Göttingen minipigs

Journal of Obesity and Bariatrics 1(1):8, 2015
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The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat

European Journal of Pharmacology 741:254-263, 2014
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The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

Journal of Clinical Investigation 124(10):4473-4488, 2014
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The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat

The Journal of Pharmacology and Experimental Therapeutics 350(3):657–664, 2014
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The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice

The Journal of Pharmacology and Experimental Therapeutics 350(2):353–360, 2014
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Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion

PLOS One 9(2):e88227, 2014
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The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat

Regulatory Peptides 189:31–9, 2014
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Characterisation of age-dependent beta cell dynamics in the male db/db mice

PLOS One 8(12):e82813, 2013
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Instruments for automated peptide synthesis

In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:215–24, 2013
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Peptide release, side-chain deprotection, work-up, and isolation

In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:43–63, 2013
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Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats

PLOS One 8(6):e65696, 2013
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Novel insight into the distribution of L-cells in the rat intestinal tract

American Journal of Translational Research 5(3):347–58, 2013
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Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helixvariants of PYY3-36

Journal of Peptide Science 18(9):579-587, 2012
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The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice

Journal of Endocrinology 214(3):381–387, 2012
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The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis

American Journal of Physiolology - Endocrinology and Metabolism 303:E253-E264, 2012
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Liraglutide: short-lived effect on gastric emptying - long lasting effects on body weight

Diabetes Obesity & Metabolism 14(6):531–538, 2012
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Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats

Acta Pharmacologica Sinica 33:194–200, 2012
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Laser capture microdissection and quantitative-PCR analysis

In: Adalberto Merighi (ed.), Neuropeptides: Methods and Protocols, Methods in Molecular Biology 789:127–35, 2011
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The brainstem preproglucagon system in a non-human primate (Macaca mulatta)

Brain Research 1397:28–37, 2011
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Stereological assessment of pancreatic beta-cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta-cell function

Journal of Anatomy 217(5):624-630, 2010
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Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

Progress in Neurobiology 92(3):442–462, 2010
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The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

Obesity (Silver Spring) 18(7):1289–1296, 2010
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The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion

Neuroscience Letters 463(2):125–129, 2009
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Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2

Brain Research Bulletin 78:202–10, 2009
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