Publications

Tap into Gubra’s vast production of publications and posters to get the latest knowledge and insights within our focus areas: diabetes, obesity, NASH and gastrointestinal diseases.

Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice

Pernille Wismann, Søren L. Pedersen, Gitte Hansen, Karin Mannerstedt, Philip J. Pedersen, Palle B. Jeppesen, Niels Vrang, Keld Fosgerau, Jacob Jelsing

Publications

Publications

Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice

INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Body-weight lowering agents and their comparative metabolic and hepatic effects in obese mouse models of non-alcoholic fatty liver disease and steatohepatitis (Gubra poster)

In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes (European Journal of Pharmacology)

Mouse models of nonalcoholic steatohepatitis in preclinical drug development (Drug Discovery Today)

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice (Molecular Metabolism)

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease (PLoS One)

Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy (World Journal of Hepatology)

The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice (Journal of Diabetes Research)

Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass (Molecular Metabolism)

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents ((PLoS One))

Neuromedin U inhibits food intake partly by inhibiting gastric emptying (Peptides)

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease (Journal of Alzheimer’s Disease)

Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain (Endocrinology)

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss (The Journal of Clinical Investigation )

The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat (The Journal of Pharmacology and Experimental Therapeutics)

The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice (The Journal of Pharmacology and Experimental Therapeutics)

Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion (PLoS One)

Characterisation of age-dependent beta cell dynamics in the male db/db mice (PLoS One)

Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats (PLoS One)

Novel insight into the distribution of L-cells in the rat intestinal tract (American Journal of Translational Research)

The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice (Journal of Endocrinology)

Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats (Acta Pharmacologica Sinica)

Stereological assessment of pancreatic beta-cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta-cell function (Journal of Anatomy)

Featured publications

INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Mouse models of nonalcoholic steatohepatitis in preclinical drug development (Drug Discovery Today)

Publications

Featured publications

INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Mouse models of nonalcoholic steatohepatitis in preclinical drug development (Drug Discovery Today)

Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice

INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis (World Journal of Gastroenterology)

Body-weight lowering agents and their comparative metabolic and hepatic effects in obese mouse models of non-alcoholic fatty liver disease and steatohepatitis (Gubra poster)

In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes (European Journal of Pharmacology)

Mouse models of nonalcoholic steatohepatitis in preclinical drug development (Drug Discovery Today)

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice (Molecular Metabolism)

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease (PLoS One)

Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy (World Journal of Hepatology)

The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice (Journal of Diabetes Research)

Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass (Molecular Metabolism)

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents ((PLoS One))

Neuromedin U inhibits food intake partly by inhibiting gastric emptying (Peptides)

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease (Journal of Alzheimer’s Disease)

Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain (Endocrinology)

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss (The Journal of Clinical Investigation )

The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat (The Journal of Pharmacology and Experimental Therapeutics)

The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice (The Journal of Pharmacology and Experimental Therapeutics)

Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion (PLoS One)

Characterisation of age-dependent beta cell dynamics in the male db/db mice (PLoS One)

Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats (PLoS One)

Novel insight into the distribution of L-cells in the rat intestinal tract (American Journal of Translational Research)

The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice (Journal of Endocrinology)

Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats (Acta Pharmacologica Sinica)

Stereological assessment of pancreatic beta-cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta-cell function (Journal of Anatomy)

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