Publications
Publications
Tap into Gubra’s vast production of publications and posters to get the latest knowledge and insights within our focus areas: diabetes, obesity, NASH and gastrointestinal diseases.
Methodologies
Disease
Model
Species
Compounds
Target
Deep learning reveals 3D atherosclerotic plaque distribution and composition
Scientific Reports 10(1):21523, 2020
Read more...An aldehyde responsive, cleavable linker for glucose responsive insulins
Chemistry European Journal [online ahead of print]
Read more...Characterization of local gut microbiome and intestinal transcriptome responses to rosiglitazone treatment in db/db mice
Biomedicine & Pharmacotherapy 133:110966
Read more...3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II
Disease Models & Mechanisms 13(12):dmm045351, 2020
Read more...An optimized mouse brain atlas for automated mapping and quantification of neuronal activity using iDISCO+ and light sheet fluorescence microscopy
Neuroinformatics [online ahead of print]
Read more...Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy
Scientific Reports 10:16130, 2020
Read more...Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative
Liver International 40:2860-2876, 2020
Read more...Low interleukin-22 binding protein is associated with high mortality in alcoholic hepatitis and modulates interleukin-22 receptor expression
Clinical and Translational Gastroenterology 11(8):e00197
Read more...Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis
BMC Gastroenterology 20:210, 2020
Read more...The selective peroxisome proliferator‐activated receptor gamma modulator CHS‐131 improves liver histopathology and metabolism in a mouse model of obesity and nonalcoholic steatohepatitis
Hepatology Communications 4(9):1302-1315, 2020
Read more...Automated image analyses of glomerular hypertrophy in a mouse model of diabetic nephropathy
Kidney360 1(6): 469-479, 2020
Read more...Whole-brain 3D imaging for quantification of drug targets and treatment effects in mouse models of neurodegenerative diseases
Neural Regeneration Research 15(12):2255-2257, 2020
Read more...Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis
Nature Metabolism 2(5):413–431, 2020
Read more...Activation of adenosine monophosphate-activated protein kinase reduces the onset of diet-induced hepatocellular carcinoma in mice
Hepatology Communications 4(7):1056-1072, 2020
Read more...Rodent models of diabetic kidney disease: human translatability and preclinical validity
Drug Discovery Today [online ahead of print]
Read more...Incretin combination therapy for the treatment of non-alcoholic steatohepatitis
Diabetes, Obesity and Metabolism 22(8):1328-1338, 2020
Read more...Glucagon resistance at the level of amino acid turnover in obese subjects with hepatic steatosis
Diabetes 69(6):1090-1099, 2020
Read more...Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis
Scientific Reports 10(1):1148, 2020
Read more...Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH
BMC Gastroenterology 19(1):228, 2019
Read more...Impact of sex on diabetic nephropathy and the renal transcriptome in UNx db/db C57BLKS mice
Physiology Reports 7(24):e14333, 2019
Read more...Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labelled neuron architecture in the mouse MPTP model of Parkinson's disease
Disease Models & Mechanisms 12(11):dmm042200, 2019
Read more...The dorsomedial hypothalamus and nucleus of the solitary tract as key regulators in a rat model of chronic obesity
Brain Research 1727:146538, 2020
Read more...Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice
Scientific Reports 9(1):15582, 2019
Read more...Mastiha (Pistacia Lentiscus) improves gut microbiota diversity, hepatic steatosis and disease activity in a biopsy-confirmed mouse model of advanced non-alcoholic steatohepatitis and fibrosis
Molecular Nutrition & Food Research 63(24):e1900927, 2019
Read more...Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source
World Journal of Gastroenterology 25(33):4904-4920, 2019
Read more...Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion
Liver International 39(11):2094-2101, 2019
Read more...Half-Life extending modifications of peptide YY3-36 direct receptor-mediated internalization
Molecular Pharmaceutics 16(8):3665-3677, 2019
Read more...RhoA in tyrosine hydroxylase neurons regulates food intake and body weight via altered sensitivity to peripheral hormones
Journal of Neuroendocrinology 31(7):e12761
Read more...Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH
Scientific Reports 9(1):9046, 2019
Read more...Hepatic molecular characteristics of patients with varying degrees of nonalcoholic steatohepatitis compared to healthy normal weight individuals
American Journal of Physiology - Gastroenterology and Liver Physiology 316(4):G462-G472, 2019
Read more...Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes
Journal of Translational Medicine 17:110, 2019
Read more...Animal models of type 2 diabetes, obesity and nonalcoholic steatohepatitis – clinical translatability and applicability in preclinical drug development
In: Krentz A., Weyer C., Hompesch M. (eds) Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. Springer, Cham. pp 369-403, 2019
Read more...The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach
Molecular Metabolism 21:36-50, 2019
Read more...Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes
Diabetes 68(1):131-140, 2019
Read more...Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice
Biomedicine & Pharmacotherapy 109:167-173, 2019
Read more...Molecular characterization of microvesicular and macrovesicular steatosis shows widespread differences in metabolic pathways
Lipids 54(1):109-115, 2019
Read more...Disease progression and pharmacological intervention in a nutrient-deficient rat model of nonalcoholic steatohepatitis
Digestive Diseases and Sciences 64(5):1238-1256, 2019
Read more...Chemical Strategies for Half-life Extension of Biopharmaceuticals: Lipidation and its Alternatives
ACS Medicinal Chemistry Letters 9(7):577-580, 2018
Read more...INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis
World Journal of Gastroenterology 24(2):195–210, 2018
Read more...Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis
World Journal of Gastroenterology 24(2):179–194, 2018
Read more...Application of the physical disector principle for quantification of dopaminergic neuronal loss in a rat 6-hydroxydopamine nigral lesion model of Parkinson’s disease
Frontiers in Neuroanatomy 11:109, 2017
Read more...GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice
Journal of Peptide Science 23(12):845–854, 2017
Read more...In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes
European Journal of Pharmacology 815:181–189, 2017
Read more...Mouse models of nonalcoholic steatohepatitis in preclinical drug development
Drug Discovery Today 22(11):1707–1718, 2017
Read more...Enteroendocrine K and L cells in healthy and type 2 diabetic individuals
Diabetologia 61(2):284–294, 2017
Read more...Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues
Journal of Medicinal Chemistry 60(17):7434–7446, 2017
Read more...A hydrogel-microsphere drug delivery system that supports once-monthly administration of a GLP-1 receptor agonist
ACS Chemical Biology 12(8):2107–2116, 2017
Read more...Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia
Kidney International 92(1):165–178, 2017
Read more...Neurturin and a GLP-1 analogue act synergistically to alleviate diabetes in Zucker diabetic fatty rats
Diabetes 66(7):2007–2018, 2017
Read more...Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model
Brain Research 1665:22–35, 2017
Read more...Neoglycolipids for prolonging the effects of peptides: Self-assembling glucagon-like peptide 1 analogues with albumin binding properties and potent in vivo efficacy
Molecular Pharmacology 14(1):193–205, 2017
Read more...Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates
Diabetes Obesity and Metabolism 18(12):1176–1190, 2016
Read more...Half-Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation
ChemMedChem 11(22):2474–2495, 2016
Read more...Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson’s disease
Brain Research 1646:354–365, 2016
Read more...Long-term treatment with liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has no effect on β-amyloid plaque load in two transgenic APP/PS1 mouse models of Alzheimer’s disease
PLOS One 11(7):e0158205, 2016
Read more...Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy
World Journal of Hepatology 8(16):673-684, 2016
Read more...The IL-1β receptor antagonist SER140 postpones the onset of diabetes in female nonobese diabetic mice
Journal of Diabetes Research 2016:7484601, 2016
Read more...Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs
American Journal of Physiology - Gastrointestinal and Liver Physiology 310(8):G550-560, 2016
Read more...The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy
Brain Research 1634:158–170, 2016
Read more...A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents
PLOS One 10(8):e0135634, 2015
Read more...The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats
Peptides 69:47–55, 2015
Read more...The GLP-1 receptor agonist liraglutide improves memory function and increases hippocampal CA1 neuronal numbers in a senescence-accelerated mouse model of Alzheimer's disease
Journal of Alzheimers Disease 46(4):877–88, 2015
Read more...Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis
Diabetes 64(3):1046–56, 2015
Read more...Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake
Journal of Peptide Science 21(2):85–94, 2015
Read more...Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) Brain
Endocrinology 156(1):255–267, 2015
Read more...The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat
European Journal of Pharmacology 741:254-263, 2014
Read more...The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss
Journal of Clinical Investigation 124(10):4473-4488, 2014
Read more...The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat
The Journal of Pharmacology and Experimental Therapeutics 350(3):657–664, 2014
Read more...The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice
The Journal of Pharmacology and Experimental Therapeutics 350(2):353–360, 2014
Read more...Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion
PLOS One 9(2):e88227, 2014
Read more...Characterisation of age-dependent beta cell dynamics in the male db/db mice
PLOS One 8(12):e82813, 2013
Read more...Instruments for automated peptide synthesis
In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:215–24, 2013
Read more...Peptide release, side-chain deprotection, work-up, and isolation
In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:43–63, 2013
Read more...Novel insight into the distribution of L-cells in the rat intestinal tract
American Journal of Translational Research 5(3):347–58, 2013
Read more...Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helixvariants of PYY3-36
Journal of Peptide Science 18(9):579-587, 2012
Read more...The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice
Journal of Endocrinology 214(3):381–387, 2012
Read more...The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis
American Journal of Physiolology - Endocrinology and Metabolism 303:E253-E264, 2012
Read more...Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats
Acta Pharmacologica Sinica 33:194–200, 2012
Read more...Laser capture microdissection and quantitative-PCR analysis
In: Adalberto Merighi (ed.), Neuropeptides: Methods and Protocols, Methods in Molecular Biology 789:127–35, 2011
Read more...The brainstem preproglucagon system in a non-human primate (Macaca mulatta)
Brain Research 1397:28–37, 2011
Read more...Stereological assessment of pancreatic beta-cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta-cell function
Journal of Anatomy 217(5):624-630, 2010
Read more...Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides
Progress in Neurobiology 92(3):442–462, 2010
Read more...The imprinted gene neuronatin is regulated by metabolic status and associated with obesity
Obesity (Silver Spring) 18(7):1289–1296, 2010
Read more...The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion
Neuroscience Letters 463(2):125–129, 2009
Read more...Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2
Brain Research Bulletin 78:202–10, 2009
Read more...Featured publications
An aldehyde responsive, cleavable linker for glucose responsive insulins
Chemistry European Journal [online ahead of print]
Read more...3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II
Disease Models & Mechanisms 13(12):dmm045351, 2020
Read more...Identification and metabolic profiling of a novel human gut-derived LEAP2 fragment
Journal of Clinical Endocrinology and Metabolism [Online ahead of print]
Read more...An optimized mouse brain atlas for automated mapping and quantification of neuronal activity using iDISCO+ and light sheet fluorescence microscopy
Neuroinformatics [online ahead of print]
Read more...Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy
Scientific Reports 10:16130, 2020
Read more...Publications
Tap into Gubra’s vast production of publications and posters to get the latest knowledge and insights within our focus areas: diabetes, obesity, NASH and gastrointestinal diseases.
Featured publications
An aldehyde responsive, cleavable linker for glucose responsive insulins
Chemistry European Journal [online ahead of print]
Read more...3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II
Disease Models & Mechanisms 13(12):dmm045351, 2020
Read more...Identification and metabolic profiling of a novel human gut-derived LEAP2 fragment
Journal of Clinical Endocrinology and Metabolism [Online ahead of print]
Read more...An optimized mouse brain atlas for automated mapping and quantification of neuronal activity using iDISCO+ and light sheet fluorescence microscopy
Neuroinformatics [online ahead of print]
Read more...Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy
Scientific Reports 10:16130, 2020
Read more...Methodologies
Disease
Model
Species
Compounds
Target
Deep learning reveals 3D atherosclerotic plaque distribution and composition
Scientific Reports 10(1):21523, 2020
Read more...An aldehyde responsive, cleavable linker for glucose responsive insulins
Chemistry European Journal [online ahead of print]
Read more...Characterization of local gut microbiome and intestinal transcriptome responses to rosiglitazone treatment in db/db mice
Biomedicine & Pharmacotherapy 133:110966
Read more...3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II
Disease Models & Mechanisms 13(12):dmm045351, 2020
Read more...An optimized mouse brain atlas for automated mapping and quantification of neuronal activity using iDISCO+ and light sheet fluorescence microscopy
Neuroinformatics [online ahead of print]
Read more...Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy
Scientific Reports 10:16130, 2020
Read more...Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative
Liver International 40:2860-2876, 2020
Read more...Low interleukin-22 binding protein is associated with high mortality in alcoholic hepatitis and modulates interleukin-22 receptor expression
Clinical and Translational Gastroenterology 11(8):e00197
Read more...Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis
BMC Gastroenterology 20:210, 2020
Read more...The selective peroxisome proliferator‐activated receptor gamma modulator CHS‐131 improves liver histopathology and metabolism in a mouse model of obesity and nonalcoholic steatohepatitis
Hepatology Communications 4(9):1302-1315, 2020
Read more...Automated image analyses of glomerular hypertrophy in a mouse model of diabetic nephropathy
Kidney360 1(6): 469-479, 2020
Read more...Whole-brain 3D imaging for quantification of drug targets and treatment effects in mouse models of neurodegenerative diseases
Neural Regeneration Research 15(12):2255-2257, 2020
Read more...Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis
Nature Metabolism 2(5):413–431, 2020
Read more...Activation of adenosine monophosphate-activated protein kinase reduces the onset of diet-induced hepatocellular carcinoma in mice
Hepatology Communications 4(7):1056-1072, 2020
Read more...Rodent models of diabetic kidney disease: human translatability and preclinical validity
Drug Discovery Today [online ahead of print]
Read more...Incretin combination therapy for the treatment of non-alcoholic steatohepatitis
Diabetes, Obesity and Metabolism 22(8):1328-1338, 2020
Read more...Glucagon resistance at the level of amino acid turnover in obese subjects with hepatic steatosis
Diabetes 69(6):1090-1099, 2020
Read more...Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis
Scientific Reports 10(1):1148, 2020
Read more...Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH
BMC Gastroenterology 19(1):228, 2019
Read more...Impact of sex on diabetic nephropathy and the renal transcriptome in UNx db/db C57BLKS mice
Physiology Reports 7(24):e14333, 2019
Read more...Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labelled neuron architecture in the mouse MPTP model of Parkinson's disease
Disease Models & Mechanisms 12(11):dmm042200, 2019
Read more...The dorsomedial hypothalamus and nucleus of the solitary tract as key regulators in a rat model of chronic obesity
Brain Research 1727:146538, 2020
Read more...Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice
Scientific Reports 9(1):15582, 2019
Read more...Mastiha (Pistacia Lentiscus) improves gut microbiota diversity, hepatic steatosis and disease activity in a biopsy-confirmed mouse model of advanced non-alcoholic steatohepatitis and fibrosis
Molecular Nutrition & Food Research 63(24):e1900927, 2019
Read more...Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source
World Journal of Gastroenterology 25(33):4904-4920, 2019
Read more...Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion
Liver International 39(11):2094-2101, 2019
Read more...Half-Life extending modifications of peptide YY3-36 direct receptor-mediated internalization
Molecular Pharmaceutics 16(8):3665-3677, 2019
Read more...RhoA in tyrosine hydroxylase neurons regulates food intake and body weight via altered sensitivity to peripheral hormones
Journal of Neuroendocrinology 31(7):e12761
Read more...Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH
Scientific Reports 9(1):9046, 2019
Read more...Hepatic molecular characteristics of patients with varying degrees of nonalcoholic steatohepatitis compared to healthy normal weight individuals
American Journal of Physiology - Gastroenterology and Liver Physiology 316(4):G462-G472, 2019
Read more...Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes
Journal of Translational Medicine 17:110, 2019
Read more...Animal models of type 2 diabetes, obesity and nonalcoholic steatohepatitis – clinical translatability and applicability in preclinical drug development
In: Krentz A., Weyer C., Hompesch M. (eds) Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. Springer, Cham. pp 369-403, 2019
Read more...The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach
Molecular Metabolism 21:36-50, 2019
Read more...Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes
Diabetes 68(1):131-140, 2019
Read more...Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice
Biomedicine & Pharmacotherapy 109:167-173, 2019
Read more...Molecular characterization of microvesicular and macrovesicular steatosis shows widespread differences in metabolic pathways
Lipids 54(1):109-115, 2019
Read more...Disease progression and pharmacological intervention in a nutrient-deficient rat model of nonalcoholic steatohepatitis
Digestive Diseases and Sciences 64(5):1238-1256, 2019
Read more...Chemical Strategies for Half-life Extension of Biopharmaceuticals: Lipidation and its Alternatives
ACS Medicinal Chemistry Letters 9(7):577-580, 2018
Read more...INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis
World Journal of Gastroenterology 24(2):195–210, 2018
Read more...Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis
World Journal of Gastroenterology 24(2):179–194, 2018
Read more...Application of the physical disector principle for quantification of dopaminergic neuronal loss in a rat 6-hydroxydopamine nigral lesion model of Parkinson’s disease
Frontiers in Neuroanatomy 11:109, 2017
Read more...GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice
Journal of Peptide Science 23(12):845–854, 2017
Read more...In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes
European Journal of Pharmacology 815:181–189, 2017
Read more...Mouse models of nonalcoholic steatohepatitis in preclinical drug development
Drug Discovery Today 22(11):1707–1718, 2017
Read more...Enteroendocrine K and L cells in healthy and type 2 diabetic individuals
Diabetologia 61(2):284–294, 2017
Read more...Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues
Journal of Medicinal Chemistry 60(17):7434–7446, 2017
Read more...A hydrogel-microsphere drug delivery system that supports once-monthly administration of a GLP-1 receptor agonist
ACS Chemical Biology 12(8):2107–2116, 2017
Read more...Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia
Kidney International 92(1):165–178, 2017
Read more...Neurturin and a GLP-1 analogue act synergistically to alleviate diabetes in Zucker diabetic fatty rats
Diabetes 66(7):2007–2018, 2017
Read more...Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model
Brain Research 1665:22–35, 2017
Read more...Neoglycolipids for prolonging the effects of peptides: Self-assembling glucagon-like peptide 1 analogues with albumin binding properties and potent in vivo efficacy
Molecular Pharmacology 14(1):193–205, 2017
Read more...Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates
Diabetes Obesity and Metabolism 18(12):1176–1190, 2016
Read more...Half-Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation
ChemMedChem 11(22):2474–2495, 2016
Read more...Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson’s disease
Brain Research 1646:354–365, 2016
Read more...Long-term treatment with liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has no effect on β-amyloid plaque load in two transgenic APP/PS1 mouse models of Alzheimer’s disease
PLOS One 11(7):e0158205, 2016
Read more...Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy
World Journal of Hepatology 8(16):673-684, 2016
Read more...The IL-1β receptor antagonist SER140 postpones the onset of diabetes in female nonobese diabetic mice
Journal of Diabetes Research 2016:7484601, 2016
Read more...Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs
American Journal of Physiology - Gastrointestinal and Liver Physiology 310(8):G550-560, 2016
Read more...The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy
Brain Research 1634:158–170, 2016
Read more...A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents
PLOS One 10(8):e0135634, 2015
Read more...The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats
Peptides 69:47–55, 2015
Read more...The GLP-1 receptor agonist liraglutide improves memory function and increases hippocampal CA1 neuronal numbers in a senescence-accelerated mouse model of Alzheimer's disease
Journal of Alzheimers Disease 46(4):877–88, 2015
Read more...Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis
Diabetes 64(3):1046–56, 2015
Read more...Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake
Journal of Peptide Science 21(2):85–94, 2015
Read more...Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) Brain
Endocrinology 156(1):255–267, 2015
Read more...The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat
European Journal of Pharmacology 741:254-263, 2014
Read more...The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss
Journal of Clinical Investigation 124(10):4473-4488, 2014
Read more...The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat
The Journal of Pharmacology and Experimental Therapeutics 350(3):657–664, 2014
Read more...The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice
The Journal of Pharmacology and Experimental Therapeutics 350(2):353–360, 2014
Read more...Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion
PLOS One 9(2):e88227, 2014
Read more...Characterisation of age-dependent beta cell dynamics in the male db/db mice
PLOS One 8(12):e82813, 2013
Read more...Instruments for automated peptide synthesis
In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:215–24, 2013
Read more...Peptide release, side-chain deprotection, work-up, and isolation
In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:43–63, 2013
Read more...Novel insight into the distribution of L-cells in the rat intestinal tract
American Journal of Translational Research 5(3):347–58, 2013
Read more...Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helixvariants of PYY3-36
Journal of Peptide Science 18(9):579-587, 2012
Read more...The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice
Journal of Endocrinology 214(3):381–387, 2012
Read more...The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis
American Journal of Physiolology - Endocrinology and Metabolism 303:E253-E264, 2012
Read more...Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats
Acta Pharmacologica Sinica 33:194–200, 2012
Read more...Laser capture microdissection and quantitative-PCR analysis
In: Adalberto Merighi (ed.), Neuropeptides: Methods and Protocols, Methods in Molecular Biology 789:127–35, 2011
Read more...The brainstem preproglucagon system in a non-human primate (Macaca mulatta)
Brain Research 1397:28–37, 2011
Read more...Stereological assessment of pancreatic beta-cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta-cell function
Journal of Anatomy 217(5):624-630, 2010
Read more...Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides
Progress in Neurobiology 92(3):442–462, 2010
Read more...The imprinted gene neuronatin is regulated by metabolic status and associated with obesity
Obesity (Silver Spring) 18(7):1289–1296, 2010
Read more...The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion
Neuroscience Letters 463(2):125–129, 2009
Read more...Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2
Brain Research Bulletin 78:202–10, 2009
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