Publications

Tap into Gubra’s vast production of publications and posters to get the latest knowledge and insights within our focus areas: diabetes, obesity, NASH and gastrointestinal diseases.

Clinical translatability of a diet-induced obese mouse model of non-alcoholic steatohepatitis [poster]

Rigbolt K, Veidal SS, Suppli M, Lykke Eriksen P, Feigh M, Knop FK, Grønbæk H, Thomsen KL, Jelsing J, Vrang N

Novel Gubra Amylin NASH (GAN) diet-induced obese mouse models of biopsy-confirmed non-alcoholic steatohepatitis [poster]

Veidal SS, Feigh M , Boland ML, Oró D, Tølbøl KS, Jelsing J, Vrang N, Hansen HH, Trevaskis JL

Hepatic molecular characteristics of patients with varying degrees of nonalcoholic steatohepatitis compared to healthy normal weight individuals

American Journal of Physiology - Gastroenterology and Liver Physiology 316(4):G462-G472, 2019

Suppli M, Rigbolt KTG, Veidal SS, Heebøll S, Demant M, Bagger JI, Thrane SW, Nielsen JC, Lund A, Strandberg C, Vilsbøll T, Vrang N, Grønbæk H, Jelsing J, Hansen HH, Knop FK

Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes

Journal of Translational Medicine 17(1):110, 2019

Schumacher‑Petersen C, Christofersen BØ, Kirk RK, Ludvigsen TP, Zois NE, Pedersen HD, Vyberg M, Olsen LH

Animal models of diabetes, obesity and non-alcoholic steatohepatitis in preclinical drug development

In: Krentz A., Weyer C., Hompesch M. (eds) Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. Springer, Cham. pp 369-403, 2019

Hansen HH, Hansen G, Secher T, Feigh M, Veidal SS, Fosgerau K, Jelsing J, Vrang N

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

Molecular Metabolism 21:36-50, 2019

Raichur S, Brunner B, Bielohuby M, Hansen G, Pfenninger A, Wang B, Bruning JC, Larsen PJ, Tennagels N

Bariatric surgery in patients with non-alcoholic fatty liver disease - from pathophysiology to clinical effects

World Journal of Hepatology 11(2):138-149, 2019

Laursen TL, Hagemann CA, Wei C, Kazankov K, Thomsen KL, Knop FK, Grønbæk H

Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes

Diabetes 68(1):131-140, 2019

Boland B, Brown C, Boland ML, Cann J, Sulikowski M, Hansen G, Grønlund RV, King W, Rondinone C, Trevaskis J, Rhodes CJ, Grimsby JS

Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice

Biomedicine & Pharmacotherapy 109:167-173, 2019

Bech EM, Voldum-Clausen K, Pedersen SL, Fabricius K, Rudkjær LCB, Hansen HH, Jelsing J

Molecular characterization of microvesicular and macrovesicular steatosis shows widespread differences in metabolic pathways

Lipids 54(1):109-115, 2019

Kristiansen MNB, Veidal SS, Christoffersen C, Jelsing J, Rigbolt KTG

Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis

Digestive Diseases and Sciences [Epub ahead of print]

Kirstine S. Tølbøl, Birgit Stierstorfer, Jörg F. Rippmann, Sanne S. Veidal, Kristoffer T. G. Rigbolt, Tanja Schönberger, Matthew P. Gillum, Henrik H. Hansen, Niels Vrang, Jacob Jelsing, Michael Feigh, Andre Broermann.

Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice

Physiology and Behavior 192:72-81, 2018

Pernille Wismann, Søren L. Pedersen, Gitte Hansen, Karin Mannerstedt, Philip J. Pedersen, Palle B. Jeppesen, Niels Vrang, Keld Fosgerau, Jacob Jelsing

Chemical Strategies for Half-life Extension of Biopharmaceuticals: Lipidation and its Alternatives

ACS Medicinal Chemistry Letters 9(7):577-580, 2018

Bech EM, Pedersen SL, Jensen K

Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control

Peptides 101:32–43, 2018

Fernandez-Cachon ML, Pedersen SL, Rigbolt KT, Zhang C, Fabricius K, Hansen HH, Elster L, Fink LN, Schäfer M, Rhee NA, Langholz E, Wandall E, Friis SU, Vilmann P, Kristiansen VB, Schmidt C, Schreiter K, Breitschopf K, Hübschle T, Jorsal T, Vilsbøll T, Schmidt T, Theis S, Knop FK, Larsen PJ, Jelsing J

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

World Journal of Gastroenterology 24(2):195–210, 2018

Jonathan D. Roth, Michael Feigh, Sanne S. Veidal, Louise K.D. Fensholdt, Kristoffer T. Rigbolt, Henrik H. Hansen, Li C. Chen, Mathieu Petitjean, Weslyn Friley, Niels Vrang, Jacob Jelsing, Mark Young

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis

World Journal of Gastroenterology 24(2):179–194, 2018

Tølbøl KS, Kristiansen MN, Hansen HH, Veidal SS, Rigbolt KT, Gillum MP, Jelsing J, Vrang N, Feigh M

Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson’s Disease

Frontiers in Neuroanatomy 11:109, 2017

Fabricius K, Barkholt P, Jelsing J, Hansen HH

GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

Journal of Peptide Science 23(12):845–854, 2017

van Witteloostuijn SB, Dalbøge LS, Hansen G, Midtgaard SR, Jensen GV, Jensen KJ, Vrang N, Jelsing J, Pedersen SL

In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes

European Journal of Pharmacology 815:181–189, 2017

Skarbaliene J, Rigbolt KT, Fosgerau K, Billestrup N

Mouse models of nonalcoholic steatohepatitis in preclinical drug development

Drug Discovery Today 22(11):1707–1718, 2017

Hansen HH, Feigh M, Veidal SS, Rigbolt KT, Vrang N, Fosgerau K.

Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

Diabetologia 61(2):284–294, 2017

Jorsal T, Rhee NA, Pedersen J, Wahlgren CD, Mortensen B, Jepsen SL, Jelsing J, Dalbøge LS, Vilmann P, Hassan H, Hendel JW, Poulsen SS, Holst JJ, Vilsbøll T, Knop FK

Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues

Journal of Medicinal Chemistry 60(17):7434–7446, 2017

Bech EM, Martos-Maldonado MC, Wismann P, Sørensen KK, van Witteloostuijn SB, Thygesen MB, Vrang N, Jelsing J, Pedersen SL, Jensen KJ

A hydrogel-microsphere drug delivery system that supports once-monthly administration of a GLP-1 receptor agonist

ACS Chemical Biology 12(8):2107–2116, 2017

Schneider EL, Hearn BR, Pfaff SJ, Reid R, Parkes DG, Vrang N, Ashley GW, Santi DV

Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia

Kidney International 92(1):165–178, 2017

Mace ML, Gravesen E, Nordholm A, Hofman-Bang J, Secher T, Olgaard K, Lewin E

Neurturin and a GLP-1 analogue act synergistically to alleviate diabetes in Zucker diabetic fatty rats

Diabetes 66(7):2007–2018, 2017

Trevaskis JL, Sacramento CB, Jouihan H, Ali S, Le Lay J, Oldham S, Bhagroo N, Boland BB, Cann J, Chang Y, O'Day T, Howard V, Reers C, Winzell MS, Smith DM, Feigh M, Barkholt P, Schreiter K, Austen M, Andag U, Thompson S, Jermutus L, Coghlan MP, Grimsby J, Dohrmann C, Rhodes CJ, Rondinone CM, Sharma A

Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model

Brain Research 1665:22–35, 2017

Helboe L, Egebjerg J, Barkholt P, Volbracht C

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice (Molecular Metabolism)

Molecular Metabolism 6(7):681–692, 2017

Wismann P, Barkholt P, Secher T, Vrang N, Hansen HB, Jeppesen PB, Baggio LL, Koehler JA, Drucker DJ, Sandoval DA, Jelsing J.

Neoglycolipids for prolonging the effects of peptides: Self-assembling glucagon-like peptide 1 analogues with albumin binding properties and potent in vivo efficacy

Molecular Pharmacology 14(1):193–205, 2017

van Witteloostuijn SB, Mannerstedt K, Wismann P, Bech EM, Thygesen MB, Vrang N, Jelsing J, Jensen KJ, Pedersen SL

Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates

Diabetes Obesity and Metabolism 18(12):1176–1190, 2016

Henderson SJ, Konkar A, Hornigold DC, Trevaskis JL, Jackson R, Fritsch Fredin M, Jansson-Löfmark R, Naylor J, Rossi A, Bednarek MA, Bhagroo N, Salari H, Will S, Oldham S, Hansen G, Feigh M, Klein T, Grimsby J, Maguire S, Jermutus L, Rondinone CM, Coghlan MP

Half-Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation

ChemMedChem 11(22):2474–2495, 2016

van Witteloostuijn SB, Pedersen SL, Jensen KJ

Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson’s disease

Brain Research 1646:354–365, 2016

Hansen HH, Fabricius K, Barkholt P, Mikkelsen JD, Jelsing J, Pyke C, Knudsen LB, Vrang N

Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery

Endocrinology 157(9):3482–92, 2016

Ratner C, Skov LJ, Raida Z, Bächler T, Bellmann-Sickert K, Le Foll C, Sivertsen B, Dalbøge LS, Hartmann B, Beck-Sickinger AG, Madsen AN, Jelsing J, Holst JJ, Lutz TA, Andrews ZB, Holst B

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease

PLOS One 11(7):e0158205, 2016

Hansen HH, Fabricius K, Barkholt P, Kongsbak-Wismann P, Schlumberger C, Jelsing J, Terwel D, Termont A, Pyke C, Knudsen LB, Vrang N.

Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy

World Journal of Hepatology 8(16):673-684, 2016

Maria Nicoline Baandrup Kristiansen, Sanne Skovgård Veidal, Kristoffer Tobias Gustav Rigbolt, Kirstine Sloth Tølbøl, Jacob Jelsing, Niels Vrang, Michael Feigh

The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice

Journal of Diabetes Research 2016:7484601, 2016

Cucak H, Hansen G, Vrang N, Skarsfeldt T, Steiness E, Jelsing J.

Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs

American Journal of Physiology - Gastrointestinal and Liver Physiology 310(8):G550-560, 2016

Hansen CF, Thymann T, Andersen AD, Holst JJ, Hartmann B, Hilsted L, Langhorn L, Jelsing J, Sangild PT

The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

Brain Research 1634:158–170, 2016

Hansen HH, Barkholt P, Fabricius K, Jelsing J, Terwel D, Pyke C, Knudsen LB, Vrang N

Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass

Molecular Metabolism 5(4):296-304, 2016

Barkholt P, Pedersen PJ, Hay-Schmidt A, Jelsing J, Hansen HH, Vrang N.

Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes

Diabetologia 58(10):2254–8, 2015

Rhee NA, Wahlgren CD, Pedersen J, Mortensen B, Langholz E, Wandall EP, Friis SU, Vilmann P, Paulsen SJ, Kristiansen VB, Jelsing J, Dalbøge LS, Poulsen SS, Holst JJ, Vilsbøll T, Knop FK

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents

PLOS One 10(8):e0135634, 2015

Dalbøge LS, Pedersen PJ, Hansen G, Fabricius K, Hansen HB, Jelsing J, Vrang N.

Neuromedin U inhibits food intake partly by inhibiting gastric emptying

Peptides 69:56–65, 2015

Dalbøge LS, Pedersen SL, Secher T, Holst B, Vrang N, Jelsing J.

The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats

Peptides 69:47–55, 2015

Skarbaliene J, Secher T, Jelsing J, Ansarullah, Neerup TS, Billestrup N, Fosgerau K

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease

Journal of Alzheimers Disease 46(4):877–88, 2015

Hansen HH, Fabricius K, Barkholt P, Niehoff ML, Morley JE, Jelsing J, Pyke C, Knudsen LB, Farr SA, Vrang N.

Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis

Diabetes 64(3):1046–56, 2015

Koehler JA, Baggio LL, Cao X, Abdulla T, Campbell JE, Secher T, Jelsing J, Larsen B, Drucker DJ

Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake

Journal of Peptide Science 21(2):85–94, 2015

Dalbøge LS, Pedersen SL, van Witteloostuijn SB, Rasmussen JE, Rigbolt KT, Jensen KJ, Holst B, Vrang N, Jelsing J

Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain

Endocrinology 156(1):255–267, 2015

Heppner KM, Kirigiti M, Secher A, Paulsen SJ, Buckingham R, Pyke C, Knudsen LB, Vrang N, Grove KL.

Post-surgical effects of Roux-en-Y gastric bypass on glucose homeostasis, intestinal morphology and L-cells in obese Göttingen minipigs

Journal of Obesity and Bariatrics 1(1):8, 2015

Barkholt P, Vegge A, Clausen TR, Birck MM, Fels JJ, Støckel M, Gögenur I, Eriksen T, Holst JJ, Hansen AK, Thymann T, Jelsing J, Sangild PT, Raun K

The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat

European Journal of Pharmacology 741:254-263, 2014

Hansen HH, Hansen G, Paulsen S, Vrang N, Mark M, Jelsing J, Klein T

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

Journal of Clinical Investigation 124(10):4473-4488, 2014

Secher A, Jelsing J, Baquero AF, Hecksher-Sørensen J, Cowley MA, Dalbøge LS, Hansen G, Grove KL, Pyke C, Raun K, Schäffer L, Tang-Christensen M, Verma S, Witgen BM, Vrang N, Bjerre Knudsen L.

The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat

The Journal of Pharmacology and Experimental Therapeutics 350(3):657–664, 2014

Hansen HH, Jelsing J, Hansen CF, Hansen G, Vrang N, Mark M, Klein T, Mayoux E.

The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice

The Journal of Pharmacology and Experimental Therapeutics 350(2):353–360, 2014

Dalbøge LS, Almholt DL, Neerup TS, Vrang N, Jelsing J, Fosgerau K.

Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion

PLOS One 9(2):e88227, 2014

Paulsen SJ, Larsen LK, Hansen G, Chelur S, Larsen PJ, Vrang N.

The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat

Regulatory Peptides 189:31–9, 2014

Hansen CF, Vassiliadis E, Vrang N, Sangild PT, Cummings BP, Havel P, Jelsing J

Characterisation of age-dependent beta cell dynamics in the male db/db mice

PLOS One 8(12):e82813, 2013

Dalbøge LS, Almholt DL, Neerup TS, Vassiliadis E, Vrang N, Pedersen L, Fosgerau K, Jelsing J.

Instruments for automated peptide synthesis

In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:215–24, 2013

Pedersen SL, Jensen KJ

Peptide release, side-chain deprotection, work-up, and isolation

In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:43–63, 2013

Pedersen SL, Jensen KJ

Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats

PLOS One 8(6):e65696, 2013

Hansen CF, Bueter M, Theis N, Lutz T, Paulsen S, Dalbøge LS, Vrang N, Jelsing J.

Novel insight into the distribution of L-cells in the rat intestinal tract

American Journal of Translational Research 5(3):347–58, 2013

Hansen CF, Vrang N, Sangild PT, Jelsing J.

Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helixvariants of PYY3-36

Journal of Peptide Science 18(9):579-587, 2012

Pedersen SL, Bhatia VK, Jurt S, Paulsson JF, Pedersen MH, Jorgensen R, Holst B, Stamou D, Vrang N, Zerbe O, Jensen KJ

The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice

Journal of Endocrinology 214(3):381–387, 2012

Jelsing J, Vrang N, van Witteloostuijn SB, Mark M, Klein T.

The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis

American Journal of Physiolology - Endocrinology and Metabolism 303:E253-E264, 2012

Vrang N, Jelsing J, Simonsen L, Jensen AE, Thorup I, Søeborg H, Knudsen LB

Liraglutide: short-lived effect on gastric emptying - long lasting effects on body weight

Diabetes Obesity & Metabolism 14(6):531–538, 2012

Jelsing J, Vrang N, Hansen G, Raun K, Tang-Christensen M, Knudsen LB

Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats

Acta Pharmacologica Sinica 33:194–200, 2012

Hansen G, Jelsing J, Vrang N.

Laser capture microdissection and quantitative-PCR analysis

In: Adalberto Merighi (ed.), Neuropeptides: Methods and Protocols, Methods in Molecular Biology 789:127–35, 2011

Paulsen SJ, Larsen LK

The brainstem preproglucagon system in a non-human primate (Macaca mulatta)

Brain Research 1397:28–37, 2011

Vrang N, Grove K

Stereological assessment of pancreatic beta-cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta-cell function

Journal of Anatomy 217(5):624-630, 2010

Paulsen SJ, Vrang N, Larsen LK, Larsen PJ, Jelsing J.

Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

Progress in Neurobiology 92(3):442–462, 2010

Vrang N, Larsen PJ

The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

Obesity (Silver Spring) 18(7):1289–1296, 2010

Vrang N, Meyre D, Froguel P, Jelsing J, Tang-Christensen M, Vatin V, Mikkelsen JD, Thirstrup K, Larsen LK, Cullberg KB, Fahrenkrug J, Jacobson P, Sjöström L, Carlsson LM, Liu Y, Liu X, Deng HW, Larsen PJ

The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion

Neuroscience Letters 463(2):125–129, 2009

Jelsing J, Larsen PJ, Vrang N

Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2

Brain Research Bulletin 78:202–10, 2009

Jelsing J, Galzin AM, Guillot E, Pruniaux MP, Larsen PJ, Vrang N

Featured publications

Hepatic molecular characteristics of patients with varying degrees of nonalcoholic steatohepatitis compared to healthy normal weight individuals

American Journal of Physiology - Gastroenterology and Liver Physiology 316(4):G462-G472, 2019

Suppli M, Rigbolt KTG, Veidal SS, Heebøll S, Demant M, Bagger JI, Thrane SW, Nielsen JC, Lund A, Strandberg C, Vilsbøll T, Vrang N, Grønbæk H, Jelsing J, Hansen HH, Knop FK

Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice

Biomedicine & Pharmacotherapy 109:167-173, 2019

Bech EM, Voldum-Clausen K, Pedersen SL, Fabricius K, Rudkjær LCB, Hansen HH, Jelsing J

Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis

Digestive Diseases and Sciences [Epub ahead of print]

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

World Journal of Gastroenterology 24(2):195–210, 2018

Jonathan D. Roth, Michael Feigh, Sanne S. Veidal, Louise K.D. Fensholdt, Kristoffer T. Rigbolt, Henrik H. Hansen, Li C. Chen, Mathieu Petitjean, Weslyn Friley, Niels Vrang, Jacob Jelsing, Mark Young

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis

World Journal of Gastroenterology 24(2):179–194, 2018

Tølbøl KS, Kristiansen MN, Hansen HH, Veidal SS, Rigbolt KT, Gillum MP, Jelsing J, Vrang N, Feigh M

Publications

Tap into Gubra’s vast production of publications and posters to get the latest knowledge and insights within our focus areas: diabetes, obesity, NASH and gastrointestinal diseases.

Featured publications

Hepatic molecular characteristics of patients with varying degrees of nonalcoholic steatohepatitis compared to healthy normal weight individuals

American Journal of Physiology - Gastroenterology and Liver Physiology 316(4):G462-G472, 2019

Suppli M, Rigbolt KTG, Veidal SS, Heebøll S, Demant M, Bagger JI, Thrane SW, Nielsen JC, Lund A, Strandberg C, Vilsbøll T, Vrang N, Grønbæk H, Jelsing J, Hansen HH, Knop FK

Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice

Biomedicine & Pharmacotherapy 109:167-173, 2019

Bech EM, Voldum-Clausen K, Pedersen SL, Fabricius K, Rudkjær LCB, Hansen HH, Jelsing J

Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis

Digestive Diseases and Sciences [Epub ahead of print]

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

World Journal of Gastroenterology 24(2):195–210, 2018

Jonathan D. Roth, Michael Feigh, Sanne S. Veidal, Louise K.D. Fensholdt, Kristoffer T. Rigbolt, Henrik H. Hansen, Li C. Chen, Mathieu Petitjean, Weslyn Friley, Niels Vrang, Jacob Jelsing, Mark Young

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis

World Journal of Gastroenterology 24(2):179–194, 2018

Tølbøl KS, Kristiansen MN, Hansen HH, Veidal SS, Rigbolt KT, Gillum MP, Jelsing J, Vrang N, Feigh M

Clinical translatability of a diet-induced obese mouse model of non-alcoholic steatohepatitis [poster]

Rigbolt K, Veidal SS, Suppli M, Lykke Eriksen P, Feigh M, Knop FK, Grønbæk H, Thomsen KL, Jelsing J, Vrang N

Novel Gubra Amylin NASH (GAN) diet-induced obese mouse models of biopsy-confirmed non-alcoholic steatohepatitis [poster]

Veidal SS, Feigh M , Boland ML, Oró D, Tølbøl KS, Jelsing J, Vrang N, Hansen HH, Trevaskis JL

Hepatic molecular characteristics of patients with varying degrees of nonalcoholic steatohepatitis compared to healthy normal weight individuals

American Journal of Physiology - Gastroenterology and Liver Physiology 316(4):G462-G472, 2019

Suppli M, Rigbolt KTG, Veidal SS, Heebøll S, Demant M, Bagger JI, Thrane SW, Nielsen JC, Lund A, Strandberg C, Vilsbøll T, Vrang N, Grønbæk H, Jelsing J, Hansen HH, Knop FK

Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes

Journal of Translational Medicine 17(1):110, 2019

Schumacher‑Petersen C, Christofersen BØ, Kirk RK, Ludvigsen TP, Zois NE, Pedersen HD, Vyberg M, Olsen LH

Animal models of diabetes, obesity and non-alcoholic steatohepatitis in preclinical drug development

In: Krentz A., Weyer C., Hompesch M. (eds) Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. Springer, Cham. pp 369-403, 2019

Hansen HH, Hansen G, Secher T, Feigh M, Veidal SS, Fosgerau K, Jelsing J, Vrang N

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

Molecular Metabolism 21:36-50, 2019

Raichur S, Brunner B, Bielohuby M, Hansen G, Pfenninger A, Wang B, Bruning JC, Larsen PJ, Tennagels N

Bariatric surgery in patients with non-alcoholic fatty liver disease - from pathophysiology to clinical effects

World Journal of Hepatology 11(2):138-149, 2019

Laursen TL, Hagemann CA, Wei C, Kazankov K, Thomsen KL, Knop FK, Grønbæk H

Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes

Diabetes 68(1):131-140, 2019

Boland B, Brown C, Boland ML, Cann J, Sulikowski M, Hansen G, Grønlund RV, King W, Rondinone C, Trevaskis J, Rhodes CJ, Grimsby JS

Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice

Biomedicine & Pharmacotherapy 109:167-173, 2019

Bech EM, Voldum-Clausen K, Pedersen SL, Fabricius K, Rudkjær LCB, Hansen HH, Jelsing J

Molecular characterization of microvesicular and macrovesicular steatosis shows widespread differences in metabolic pathways

Lipids 54(1):109-115, 2019

Kristiansen MNB, Veidal SS, Christoffersen C, Jelsing J, Rigbolt KTG

Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis

Digestive Diseases and Sciences [Epub ahead of print]

Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice

Physiology and Behavior 192:72-81, 2018

Pernille Wismann, Søren L. Pedersen, Gitte Hansen, Karin Mannerstedt, Philip J. Pedersen, Palle B. Jeppesen, Niels Vrang, Keld Fosgerau, Jacob Jelsing

Chemical Strategies for Half-life Extension of Biopharmaceuticals: Lipidation and its Alternatives

ACS Medicinal Chemistry Letters 9(7):577-580, 2018

Bech EM, Pedersen SL, Jensen K

Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control

Peptides 101:32–43, 2018

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

World Journal of Gastroenterology 24(2):195–210, 2018

Jonathan D. Roth, Michael Feigh, Sanne S. Veidal, Louise K.D. Fensholdt, Kristoffer T. Rigbolt, Henrik H. Hansen, Li C. Chen, Mathieu Petitjean, Weslyn Friley, Niels Vrang, Jacob Jelsing, Mark Young

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis

World Journal of Gastroenterology 24(2):179–194, 2018

Tølbøl KS, Kristiansen MN, Hansen HH, Veidal SS, Rigbolt KT, Gillum MP, Jelsing J, Vrang N, Feigh M

Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson’s Disease

Frontiers in Neuroanatomy 11:109, 2017

Fabricius K, Barkholt P, Jelsing J, Hansen HH

GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

Journal of Peptide Science 23(12):845–854, 2017

van Witteloostuijn SB, Dalbøge LS, Hansen G, Midtgaard SR, Jensen GV, Jensen KJ, Vrang N, Jelsing J, Pedersen SL

In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes

European Journal of Pharmacology 815:181–189, 2017

Skarbaliene J, Rigbolt KT, Fosgerau K, Billestrup N

Mouse models of nonalcoholic steatohepatitis in preclinical drug development

Drug Discovery Today 22(11):1707–1718, 2017

Hansen HH, Feigh M, Veidal SS, Rigbolt KT, Vrang N, Fosgerau K.

Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

Diabetologia 61(2):284–294, 2017

Jorsal T, Rhee NA, Pedersen J, Wahlgren CD, Mortensen B, Jepsen SL, Jelsing J, Dalbøge LS, Vilmann P, Hassan H, Hendel JW, Poulsen SS, Holst JJ, Vilsbøll T, Knop FK

Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues

Journal of Medicinal Chemistry 60(17):7434–7446, 2017

Bech EM, Martos-Maldonado MC, Wismann P, Sørensen KK, van Witteloostuijn SB, Thygesen MB, Vrang N, Jelsing J, Pedersen SL, Jensen KJ

A hydrogel-microsphere drug delivery system that supports once-monthly administration of a GLP-1 receptor agonist

ACS Chemical Biology 12(8):2107–2116, 2017

Schneider EL, Hearn BR, Pfaff SJ, Reid R, Parkes DG, Vrang N, Ashley GW, Santi DV

Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia

Kidney International 92(1):165–178, 2017

Mace ML, Gravesen E, Nordholm A, Hofman-Bang J, Secher T, Olgaard K, Lewin E

Neurturin and a GLP-1 analogue act synergistically to alleviate diabetes in Zucker diabetic fatty rats

Diabetes 66(7):2007–2018, 2017

Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model

Brain Research 1665:22–35, 2017

Helboe L, Egebjerg J, Barkholt P, Volbracht C

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice (Molecular Metabolism)

Molecular Metabolism 6(7):681–692, 2017

Wismann P, Barkholt P, Secher T, Vrang N, Hansen HB, Jeppesen PB, Baggio LL, Koehler JA, Drucker DJ, Sandoval DA, Jelsing J.

Neoglycolipids for prolonging the effects of peptides: Self-assembling glucagon-like peptide 1 analogues with albumin binding properties and potent in vivo efficacy

Molecular Pharmacology 14(1):193–205, 2017

van Witteloostuijn SB, Mannerstedt K, Wismann P, Bech EM, Thygesen MB, Vrang N, Jelsing J, Jensen KJ, Pedersen SL

Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates

Diabetes Obesity and Metabolism 18(12):1176–1190, 2016

Half-Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation

ChemMedChem 11(22):2474–2495, 2016

van Witteloostuijn SB, Pedersen SL, Jensen KJ

Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson’s disease

Brain Research 1646:354–365, 2016

Hansen HH, Fabricius K, Barkholt P, Mikkelsen JD, Jelsing J, Pyke C, Knudsen LB, Vrang N

Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery

Endocrinology 157(9):3482–92, 2016

Ratner C, Skov LJ, Raida Z, Bächler T, Bellmann-Sickert K, Le Foll C, Sivertsen B, Dalbøge LS, Hartmann B, Beck-Sickinger AG, Madsen AN, Jelsing J, Holst JJ, Lutz TA, Andrews ZB, Holst B

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease

PLOS One 11(7):e0158205, 2016

Hansen HH, Fabricius K, Barkholt P, Kongsbak-Wismann P, Schlumberger C, Jelsing J, Terwel D, Termont A, Pyke C, Knudsen LB, Vrang N.

Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy

World Journal of Hepatology 8(16):673-684, 2016

Maria Nicoline Baandrup Kristiansen, Sanne Skovgård Veidal, Kristoffer Tobias Gustav Rigbolt, Kirstine Sloth Tølbøl, Jacob Jelsing, Niels Vrang, Michael Feigh

The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice

Journal of Diabetes Research 2016:7484601, 2016

Cucak H, Hansen G, Vrang N, Skarsfeldt T, Steiness E, Jelsing J.

Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs

American Journal of Physiology - Gastrointestinal and Liver Physiology 310(8):G550-560, 2016

Hansen CF, Thymann T, Andersen AD, Holst JJ, Hartmann B, Hilsted L, Langhorn L, Jelsing J, Sangild PT

The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

Brain Research 1634:158–170, 2016

Hansen HH, Barkholt P, Fabricius K, Jelsing J, Terwel D, Pyke C, Knudsen LB, Vrang N

Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass

Molecular Metabolism 5(4):296-304, 2016

Barkholt P, Pedersen PJ, Hay-Schmidt A, Jelsing J, Hansen HH, Vrang N.

Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes

Diabetologia 58(10):2254–8, 2015

Rhee NA, Wahlgren CD, Pedersen J, Mortensen B, Langholz E, Wandall EP, Friis SU, Vilmann P, Paulsen SJ, Kristiansen VB, Jelsing J, Dalbøge LS, Poulsen SS, Holst JJ, Vilsbøll T, Knop FK

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents

PLOS One 10(8):e0135634, 2015

Dalbøge LS, Pedersen PJ, Hansen G, Fabricius K, Hansen HB, Jelsing J, Vrang N.

Neuromedin U inhibits food intake partly by inhibiting gastric emptying

Peptides 69:56–65, 2015

Dalbøge LS, Pedersen SL, Secher T, Holst B, Vrang N, Jelsing J.

The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats

Peptides 69:47–55, 2015

Skarbaliene J, Secher T, Jelsing J, Ansarullah, Neerup TS, Billestrup N, Fosgerau K

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease

Journal of Alzheimers Disease 46(4):877–88, 2015

Hansen HH, Fabricius K, Barkholt P, Niehoff ML, Morley JE, Jelsing J, Pyke C, Knudsen LB, Farr SA, Vrang N.

Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis

Diabetes 64(3):1046–56, 2015

Koehler JA, Baggio LL, Cao X, Abdulla T, Campbell JE, Secher T, Jelsing J, Larsen B, Drucker DJ

Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake

Journal of Peptide Science 21(2):85–94, 2015

Dalbøge LS, Pedersen SL, van Witteloostuijn SB, Rasmussen JE, Rigbolt KT, Jensen KJ, Holst B, Vrang N, Jelsing J

Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain

Endocrinology 156(1):255–267, 2015

Heppner KM, Kirigiti M, Secher A, Paulsen SJ, Buckingham R, Pyke C, Knudsen LB, Vrang N, Grove KL.

Post-surgical effects of Roux-en-Y gastric bypass on glucose homeostasis, intestinal morphology and L-cells in obese Göttingen minipigs

Journal of Obesity and Bariatrics 1(1):8, 2015

Barkholt P, Vegge A, Clausen TR, Birck MM, Fels JJ, Støckel M, Gögenur I, Eriksen T, Holst JJ, Hansen AK, Thymann T, Jelsing J, Sangild PT, Raun K

The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat

European Journal of Pharmacology 741:254-263, 2014

Hansen HH, Hansen G, Paulsen S, Vrang N, Mark M, Jelsing J, Klein T

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

Journal of Clinical Investigation 124(10):4473-4488, 2014

Secher A, Jelsing J, Baquero AF, Hecksher-Sørensen J, Cowley MA, Dalbøge LS, Hansen G, Grove KL, Pyke C, Raun K, Schäffer L, Tang-Christensen M, Verma S, Witgen BM, Vrang N, Bjerre Knudsen L.

The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat

The Journal of Pharmacology and Experimental Therapeutics 350(3):657–664, 2014

Hansen HH, Jelsing J, Hansen CF, Hansen G, Vrang N, Mark M, Klein T, Mayoux E.

The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice

The Journal of Pharmacology and Experimental Therapeutics 350(2):353–360, 2014

Dalbøge LS, Almholt DL, Neerup TS, Vrang N, Jelsing J, Fosgerau K.

Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion

PLOS One 9(2):e88227, 2014

Paulsen SJ, Larsen LK, Hansen G, Chelur S, Larsen PJ, Vrang N.

The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat

Regulatory Peptides 189:31–9, 2014

Hansen CF, Vassiliadis E, Vrang N, Sangild PT, Cummings BP, Havel P, Jelsing J

Characterisation of age-dependent beta cell dynamics in the male db/db mice

PLOS One 8(12):e82813, 2013

Dalbøge LS, Almholt DL, Neerup TS, Vassiliadis E, Vrang N, Pedersen L, Fosgerau K, Jelsing J.

Instruments for automated peptide synthesis

In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:215–24, 2013

Pedersen SL, Jensen KJ

Peptide release, side-chain deprotection, work-up, and isolation

In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:43–63, 2013

Pedersen SL, Jensen KJ

Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats

PLOS One 8(6):e65696, 2013

Hansen CF, Bueter M, Theis N, Lutz T, Paulsen S, Dalbøge LS, Vrang N, Jelsing J.

Novel insight into the distribution of L-cells in the rat intestinal tract

American Journal of Translational Research 5(3):347–58, 2013

Hansen CF, Vrang N, Sangild PT, Jelsing J.

Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helixvariants of PYY3-36

Journal of Peptide Science 18(9):579-587, 2012

Pedersen SL, Bhatia VK, Jurt S, Paulsson JF, Pedersen MH, Jorgensen R, Holst B, Stamou D, Vrang N, Zerbe O, Jensen KJ

The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice

Journal of Endocrinology 214(3):381–387, 2012

Jelsing J, Vrang N, van Witteloostuijn SB, Mark M, Klein T.

The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis

American Journal of Physiolology - Endocrinology and Metabolism 303:E253-E264, 2012

Vrang N, Jelsing J, Simonsen L, Jensen AE, Thorup I, Søeborg H, Knudsen LB

Liraglutide: short-lived effect on gastric emptying - long lasting effects on body weight

Diabetes Obesity & Metabolism 14(6):531–538, 2012

Jelsing J, Vrang N, Hansen G, Raun K, Tang-Christensen M, Knudsen LB

Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats

Acta Pharmacologica Sinica 33:194–200, 2012

Hansen G, Jelsing J, Vrang N.

Laser capture microdissection and quantitative-PCR analysis

In: Adalberto Merighi (ed.), Neuropeptides: Methods and Protocols, Methods in Molecular Biology 789:127–35, 2011

Paulsen SJ, Larsen LK

The brainstem preproglucagon system in a non-human primate (Macaca mulatta)

Brain Research 1397:28–37, 2011

Vrang N, Grove K

Stereological assessment of pancreatic beta-cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta-cell function

Journal of Anatomy 217(5):624-630, 2010

Paulsen SJ, Vrang N, Larsen LK, Larsen PJ, Jelsing J.

Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

Progress in Neurobiology 92(3):442–462, 2010

Vrang N, Larsen PJ

The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

Obesity (Silver Spring) 18(7):1289–1296, 2010

The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion

Neuroscience Letters 463(2):125–129, 2009

Jelsing J, Larsen PJ, Vrang N

Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2

Brain Research Bulletin 78:202–10, 2009

Jelsing J, Galzin AM, Guillot E, Pruniaux MP, Larsen PJ, Vrang N

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