Publications

Publications

Tap into Gubra’s vast production of publications and posters to get the latest knowledge and insights within our focus areas: diabetes, obesity, NASH and gastrointestinal diseases.

Methodologies

Disease

Compounds

Species

Model

Target

Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion

Liver International [Epub ahead of print]
Read more...

Half-Life Extending Modifications of Peptide YY3-36 Direct Receptor-Mediated Internalization

Molecular Pharmaceutics 16: 3665-3677, 2019
Read more...

Investigating Intestinal Glucagon after Roux-en-Y Gastric Bypass Surgery

Journal of Clinical Endocrinology & Metabolism [Epub ahead of print]
Read more...

RhoA in tyrosine hydroxylase neurons regulates food intake and body weight via altered sensitivity to peripheral hormones

Journal of Neuroendocrinology 31(7):e12761
Read more...

Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH

Scientific Reports 9:9046, 2019
Read more...

The preprohormone expression profile of enteroendocrine cells following Roux-en-Y gastric bypass in rats

Peptides [Epub ahead of print]
Read more...

Hepatic molecular characteristics of patients with varying degrees of nonalcoholic steatohepatitis compared to healthy normal weight individuals

American Journal of Physiology - Gastroenterology and Liver Physiology 316(4):G462-G472, 2019
Read more...

Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes

Journal of Translational Medicine 17(1):110, 2019
Read more...

Animal models of type 2 diabetes, obesity and nonalcoholic steatohepatitis – clinical translatability and applicability in preclinical drug development

In: Krentz A., Weyer C., Hompesch M. (eds) Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. Springer, Cham. pp 369-403, 2019
Read more...

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

Molecular Metabolism 21:36-50, 2019
Read more...

Bariatric surgery in patients with non-alcoholic fatty liver disease - from pathophysiology to clinical effects

World Journal of Hepatology 11(2):138-149, 2019
Read more...

Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes

Diabetes 68(1):131-140, 2019
Read more...

Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice

Biomedicine & Pharmacotherapy 109:167-173, 2019
Read more...

Molecular characterization of microvesicular and macrovesicular steatosis shows widespread differences in metabolic pathways

Lipids 54(1):109-115, 2019
Read more...

Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis

Digestive Diseases and Sciences 64(5):1238-1256, 2019
Read more...

Flow cytometry reveals distinct changes in hepatic inflammatory cell populations in a diet-induced obese mouse model of non-alcoholic steatohepatitis [poster]

The Liver Meeting (2018)
Read more...

Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice

Physiology and Behavior 192:72-81, 2018
Read more...

Chemical Strategies for Half-life Extension of Biopharmaceuticals: Lipidation and its Alternatives

ACS Medicinal Chemistry Letters 9(7):577-580, 2018
Read more...

Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control

Peptides 101:32–43, 2018
Read more...

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

World Journal of Gastroenterology 24(2):195–210, 2018
Read more...

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis

World Journal of Gastroenterology 24(2):179–194, 2018
Read more...

Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson’s Disease

Frontiers in Neuroanatomy 11:109, 2017
Read more...

GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

Journal of Peptide Science 23(12):845–854, 2017
Read more...

In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes

European Journal of Pharmacology 815:181–189, 2017
Read more...

Mouse models of nonalcoholic steatohepatitis in preclinical drug development

Drug Discovery Today 22(11):1707–1718, 2017
Read more...

Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

Diabetologia 61(2):284–294, 2017
Read more...

Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues

Journal of Medicinal Chemistry 60(17):7434–7446, 2017
Read more...

A hydrogel-microsphere drug delivery system that supports once-monthly administration of a GLP-1 receptor agonist

ACS Chemical Biology 12(8):2107–2116, 2017
Read more...

Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia

Kidney International 92(1):165–178, 2017
Read more...

Neurturin and a GLP-1 analogue act synergistically to alleviate diabetes in Zucker diabetic fatty rats

Diabetes 66(7):2007–2018, 2017
Read more...

Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model

Brain Research 1665:22–35, 2017
Read more...

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice

Molecular Metabolism 6(7):681–692, 2017
Read more...

Neoglycolipids for prolonging the effects of peptides: Self-assembling glucagon-like peptide 1 analogues with albumin binding properties and potent in vivo efficacy

Molecular Pharmacology 14(1):193–205, 2017
Read more...

Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates

Diabetes Obesity and Metabolism 18(12):1176–1190, 2016
Read more...

Half-Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation

ChemMedChem 11(22):2474–2495, 2016
Read more...

Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor  agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson’s disease

Brain Research 1646:354–365, 2016
Read more...

Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery

Endocrinology 157(9):3482–92, 2016
Read more...

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease

PLOS One 11(7):e0158205, 2016
Read more...

Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy

World Journal of Hepatology 8(16):673-684, 2016
Read more...

The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice

Journal of Diabetes Research 2016:7484601, 2016
Read more...

Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs

American Journal of Physiology - Gastrointestinal and Liver Physiology 310(8):G550-560, 2016
Read more...

The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

Brain Research 1634:158–170, 2016
Read more...

Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass

Molecular Metabolism 5(4):296-304, 2016
Read more...

Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes

Diabetologia 58(10):2254–8, 2015
Read more...

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents

PLOS One 10(8):e0135634, 2015
Read more...

Neuromedin U inhibits food intake partly by inhibiting gastric emptying

Peptides 69:56–65, 2015
Read more...

The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats

Peptides 69:47–55, 2015
Read more...

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease

Journal of Alzheimers Disease 46(4):877–88, 2015
Read more...

Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis

Diabetes 64(3):1046–56, 2015
Read more...

Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake

Journal of Peptide Science 21(2):85–94, 2015
Read more...

Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain

Endocrinology 156(1):255–267, 2015
Read more...

Post-surgical effects of Roux-en-Y gastric bypass on glucose homeostasis, intestinal morphology and L-cells in obese Göttingen minipigs

Journal of Obesity and Bariatrics 1(1):8, 2015
Read more...

The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat

European Journal of Pharmacology 741:254-263, 2014
Read more...

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

Journal of Clinical Investigation 124(10):4473-4488, 2014
Read more...

The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat

The Journal of Pharmacology and Experimental Therapeutics 350(3):657–664, 2014
Read more...

The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice

The Journal of Pharmacology and Experimental Therapeutics 350(2):353–360, 2014
Read more...

Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion

PLOS One 9(2):e88227, 2014
Read more...

The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat

Regulatory Peptides 189:31–9, 2014
Read more...

Characterisation of age-dependent beta cell dynamics in the male db/db mice

PLOS One 8(12):e82813, 2013
Read more...

Instruments for automated peptide synthesis

In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:215–24, 2013
Read more...

Peptide release, side-chain deprotection, work-up, and isolation

In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:43–63, 2013
Read more...

Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats

PLOS One 8(6):e65696, 2013
Read more...

Novel insight into the distribution of L-cells in the rat intestinal tract

American Journal of Translational Research 5(3):347–58, 2013
Read more...

Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helixvariants of PYY3-36

Journal of Peptide Science 18(9):579-587, 2012
Read more...

The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice

Journal of Endocrinology 214(3):381–387, 2012
Read more...

The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis

American Journal of Physiolology - Endocrinology and Metabolism 303:E253-E264, 2012
Read more...

Liraglutide: short-lived effect on gastric emptying - long lasting effects on body weight

Diabetes Obesity & Metabolism 14(6):531–538, 2012
Read more...

Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats

Acta Pharmacologica Sinica 33:194–200, 2012
Read more...

Laser capture microdissection and quantitative-PCR analysis

In: Adalberto Merighi (ed.), Neuropeptides: Methods and Protocols, Methods in Molecular Biology 789:127–35, 2011
Read more...

The brainstem preproglucagon system in a non-human primate (Macaca mulatta)

Brain Research 1397:28–37, 2011
Read more...

Stereological assessment of pancreatic beta-cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta-cell function

Journal of Anatomy 217(5):624-630, 2010
Read more...

Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

Progress in Neurobiology 92(3):442–462, 2010
Read more...

The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

Obesity (Silver Spring) 18(7):1289–1296, 2010
Read more...

The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion

Neuroscience Letters 463(2):125–129, 2009
Read more...

Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2

Brain Research Bulletin 78:202–10, 2009
Read more...

Featured publications

Half-Life Extending Modifications of Peptide YY3-36 Direct Receptor-Mediated Internalization

Molecular Pharmaceutics 16: 3665-3677, 2019
Read more...

Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH

Scientific Reports 9:9046, 2019
Read more...

The preprohormone expression profile of enteroendocrine cells following Roux-en-Y gastric bypass in rats

Peptides [Epub ahead of print]
Read more...

Hepatic molecular characteristics of patients with varying degrees of nonalcoholic steatohepatitis compared to healthy normal weight individuals

American Journal of Physiology - Gastroenterology and Liver Physiology 316(4):G462-G472, 2019
Read more...

Animal models of type 2 diabetes, obesity and nonalcoholic steatohepatitis – clinical translatability and applicability in preclinical drug development

In: Krentz A., Weyer C., Hompesch M. (eds) Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. Springer, Cham. pp 369-403, 2019
Read more...

Publications

Tap into Gubra’s vast production of publications and posters to get the latest knowledge and insights within our focus areas: diabetes, obesity, NASH and gastrointestinal diseases.

Featured publications

Half-Life Extending Modifications of Peptide YY3-36 Direct Receptor-Mediated Internalization

Molecular Pharmaceutics 16: 3665-3677, 2019
Read more...

Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH

Scientific Reports 9:9046, 2019
Read more...

The preprohormone expression profile of enteroendocrine cells following Roux-en-Y gastric bypass in rats

Peptides [Epub ahead of print]
Read more...

Hepatic molecular characteristics of patients with varying degrees of nonalcoholic steatohepatitis compared to healthy normal weight individuals

American Journal of Physiology - Gastroenterology and Liver Physiology 316(4):G462-G472, 2019
Read more...

Animal models of type 2 diabetes, obesity and nonalcoholic steatohepatitis – clinical translatability and applicability in preclinical drug development

In: Krentz A., Weyer C., Hompesch M. (eds) Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. Springer, Cham. pp 369-403, 2019
Read more...

Methodologies

Disease

Compounds

Species

Model

Target

Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion

Liver International [Epub ahead of print]
Read more...

Half-Life Extending Modifications of Peptide YY3-36 Direct Receptor-Mediated Internalization

Molecular Pharmaceutics 16: 3665-3677, 2019
Read more...

Investigating Intestinal Glucagon after Roux-en-Y Gastric Bypass Surgery

Journal of Clinical Endocrinology & Metabolism [Epub ahead of print]
Read more...

RhoA in tyrosine hydroxylase neurons regulates food intake and body weight via altered sensitivity to peripheral hormones

Journal of Neuroendocrinology 31(7):e12761
Read more...

Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH

Scientific Reports 9:9046, 2019
Read more...

The preprohormone expression profile of enteroendocrine cells following Roux-en-Y gastric bypass in rats

Peptides [Epub ahead of print]
Read more...

Hepatic molecular characteristics of patients with varying degrees of nonalcoholic steatohepatitis compared to healthy normal weight individuals

American Journal of Physiology - Gastroenterology and Liver Physiology 316(4):G462-G472, 2019
Read more...

Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes

Journal of Translational Medicine 17(1):110, 2019
Read more...

Animal models of type 2 diabetes, obesity and nonalcoholic steatohepatitis – clinical translatability and applicability in preclinical drug development

In: Krentz A., Weyer C., Hompesch M. (eds) Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease. Springer, Cham. pp 369-403, 2019
Read more...

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

Molecular Metabolism 21:36-50, 2019
Read more...

Bariatric surgery in patients with non-alcoholic fatty liver disease - from pathophysiology to clinical effects

World Journal of Hepatology 11(2):138-149, 2019
Read more...

Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes

Diabetes 68(1):131-140, 2019
Read more...

Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice

Biomedicine & Pharmacotherapy 109:167-173, 2019
Read more...

Molecular characterization of microvesicular and macrovesicular steatosis shows widespread differences in metabolic pathways

Lipids 54(1):109-115, 2019
Read more...

Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis

Digestive Diseases and Sciences 64(5):1238-1256, 2019
Read more...

Flow cytometry reveals distinct changes in hepatic inflammatory cell populations in a diet-induced obese mouse model of non-alcoholic steatohepatitis [poster]

The Liver Meeting (2018)
Read more...

Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice

Physiology and Behavior 192:72-81, 2018
Read more...

Chemical Strategies for Half-life Extension of Biopharmaceuticals: Lipidation and its Alternatives

ACS Medicinal Chemistry Letters 9(7):577-580, 2018
Read more...

Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control

Peptides 101:32–43, 2018
Read more...

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

World Journal of Gastroenterology 24(2):195–210, 2018
Read more...

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis

World Journal of Gastroenterology 24(2):179–194, 2018
Read more...

Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson’s Disease

Frontiers in Neuroanatomy 11:109, 2017
Read more...

GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

Journal of Peptide Science 23(12):845–854, 2017
Read more...

In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes

European Journal of Pharmacology 815:181–189, 2017
Read more...

Mouse models of nonalcoholic steatohepatitis in preclinical drug development

Drug Discovery Today 22(11):1707–1718, 2017
Read more...

Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

Diabetologia 61(2):284–294, 2017
Read more...

Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues

Journal of Medicinal Chemistry 60(17):7434–7446, 2017
Read more...

A hydrogel-microsphere drug delivery system that supports once-monthly administration of a GLP-1 receptor agonist

ACS Chemical Biology 12(8):2107–2116, 2017
Read more...

Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia

Kidney International 92(1):165–178, 2017
Read more...

Neurturin and a GLP-1 analogue act synergistically to alleviate diabetes in Zucker diabetic fatty rats

Diabetes 66(7):2007–2018, 2017
Read more...

Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model

Brain Research 1665:22–35, 2017
Read more...

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice

Molecular Metabolism 6(7):681–692, 2017
Read more...

Neoglycolipids for prolonging the effects of peptides: Self-assembling glucagon-like peptide 1 analogues with albumin binding properties and potent in vivo efficacy

Molecular Pharmacology 14(1):193–205, 2017
Read more...

Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates

Diabetes Obesity and Metabolism 18(12):1176–1190, 2016
Read more...

Half-Life Extension of Biopharmaceuticals using Chemical Methods: Alternatives to PEGylation

ChemMedChem 11(22):2474–2495, 2016
Read more...

Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor  agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson’s disease

Brain Research 1646:354–365, 2016
Read more...

Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery

Endocrinology 157(9):3482–92, 2016
Read more...

Long-Term Treatment with Liraglutide, a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist, Has No Effect on β-Amyloid Plaque Load in Two Transgenic APP/PS1 Mouse Models of Alzheimer’s Disease

PLOS One 11(7):e0158205, 2016
Read more...

Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy

World Journal of Hepatology 8(16):673-684, 2016
Read more...

The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice

Journal of Diabetes Research 2016:7484601, 2016
Read more...

Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs

American Journal of Physiology - Gastrointestinal and Liver Physiology 310(8):G550-560, 2016
Read more...

The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

Brain Research 1634:158–170, 2016
Read more...

Alterations in hypothalamic gene expression following Roux-en-Y gastric bypass

Molecular Metabolism 5(4):296-304, 2016
Read more...

Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes

Diabetologia 58(10):2254–8, 2015
Read more...

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents

PLOS One 10(8):e0135634, 2015
Read more...

Neuromedin U inhibits food intake partly by inhibiting gastric emptying

Peptides 69:56–65, 2015
Read more...

The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats

Peptides 69:47–55, 2015
Read more...

The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease

Journal of Alzheimers Disease 46(4):877–88, 2015
Read more...

Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis

Diabetes 64(3):1046–56, 2015
Read more...

Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake

Journal of Peptide Science 21(2):85–94, 2015
Read more...

Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain

Endocrinology 156(1):255–267, 2015
Read more...

Post-surgical effects of Roux-en-Y gastric bypass on glucose homeostasis, intestinal morphology and L-cells in obese Göttingen minipigs

Journal of Obesity and Bariatrics 1(1):8, 2015
Read more...

The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat

European Journal of Pharmacology 741:254-263, 2014
Read more...

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

Journal of Clinical Investigation 124(10):4473-4488, 2014
Read more...

The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves β-cell mass and restores glucose homeostasis in the male zucker diabetic fatty rat

The Journal of Pharmacology and Experimental Therapeutics 350(3):657–664, 2014
Read more...

The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice

The Journal of Pharmacology and Experimental Therapeutics 350(2):353–360, 2014
Read more...

Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion

PLOS One 9(2):e88227, 2014
Read more...

The effect of ileal interposition surgery on enteroendocrine cell numbers in the UC Davis type 2 diabetes mellitus rat

Regulatory Peptides 189:31–9, 2014
Read more...

Characterisation of age-dependent beta cell dynamics in the male db/db mice

PLOS One 8(12):e82813, 2013
Read more...

Instruments for automated peptide synthesis

In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:215–24, 2013
Read more...

Peptide release, side-chain deprotection, work-up, and isolation

In: Knud J. Jensen et al. (eds.), Peptide Synthesis and Applications, Methods in Molecular Biology, 1047:43–63, 2013
Read more...

Hypertrophy dependent doubling of L-cells in Roux-en-Y gastric bypass operated rats

PLOS One 8(6):e65696, 2013
Read more...

Novel insight into the distribution of L-cells in the rat intestinal tract

American Journal of Translational Research 5(3):347–58, 2013
Read more...

Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helixvariants of PYY3-36

Journal of Peptide Science 18(9):579-587, 2012
Read more...

The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice

Journal of Endocrinology 214(3):381–387, 2012
Read more...

The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis

American Journal of Physiolology - Endocrinology and Metabolism 303:E253-E264, 2012
Read more...

Liraglutide: short-lived effect on gastric emptying - long lasting effects on body weight

Diabetes Obesity & Metabolism 14(6):531–538, 2012
Read more...

Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats

Acta Pharmacologica Sinica 33:194–200, 2012
Read more...

Laser capture microdissection and quantitative-PCR analysis

In: Adalberto Merighi (ed.), Neuropeptides: Methods and Protocols, Methods in Molecular Biology 789:127–35, 2011
Read more...

The brainstem preproglucagon system in a non-human primate (Macaca mulatta)

Brain Research 1397:28–37, 2011
Read more...

Stereological assessment of pancreatic beta-cell mass development in male Zucker Diabetic Fatty (ZDF) rats: correlation with pancreatic beta-cell function

Journal of Anatomy 217(5):624-630, 2010
Read more...

Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides

Progress in Neurobiology 92(3):442–462, 2010
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The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

Obesity (Silver Spring) 18(7):1289–1296, 2010
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The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion

Neuroscience Letters 463(2):125–129, 2009
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Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2

Brain Research Bulletin 78:202–10, 2009
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