Publications

Tap into Gubra’s vast production of publications and posters to get the latest knowledge and insights within our focus areas: diabetes, obesity, NASH and gastrointestinal diseases.

GIP affects hepatic fat and brown adipose tissue thermogenesis, but not white adipose tissue transcriptome in T1D

Journal of Clinical Endocrinology and Metabolism [online ahead of print]

Heimbürger SMN, Hoe B, Nielsen CN, Bergman NC, Skov-Jeppesen K, Hartmann B, Holst JJ, Dela F, Overgaard J, Størling J, Vilsbøll T, Dejgaard TF, Havelund JF, Gorshkov V, Kjeldsen F, Færgeman NJK, Madsen MR, Christensen MB, Knop FK

Publications

Publications

GIP affects hepatic fat and brown adipose tissue thermogenesis, but not white adipose tissue transcriptome in T1D

Nuclear morphology is a deep learning biomarker of cellular senescence

Nephroprotective effects of semaglutide as mono- and combination treatment with lisinopril in a mouse model of hypertension-accelerated diabetic kidney disease

Structurally-engineered fatty acid 1024 (SEFA-1024) improves diet-induced obesity, insulin resistance, and fatty liver disease

LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men

Effects of ALT-801, a GLP-1 and glucagon receptor dual agonist, in a translational mouse model of non-alcoholic steatohepatitis

Digital brain maps and virtual neuroscience. An emerging role for light sheet fluorescence microscopy in drug development

Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH

Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect

Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese-diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries

Integrative transcriptomic profiling of a mouse model of hypertension-accelerated diabetic kidney disease

Therapeutic effects of lisinopril and empagliflozin in a mouse model of hypertension-accelerated diabetic kidney disease

Empagliflozin improves metabolic and hepatic outcomes in a non-diabetic obese biopsy-proven mouse model of advanced NASH

Comparative study of voxel-based statistical analysis methods for fluorescently labelled and light sheet imaged whole-brain samples

Whole-brain mapping of amylin-induced neuronal activity in receptor activity–modifying protein (RAMP) 1/3 knockout mice

Characterization of combined linagliptin and Y2R agonist treatment in diet-induced obese mice

Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism

Elafibranor and liraglutide improve differentially liver health and metabolism in a mouse model of non-alcoholic steatohepatitis

A genetic map of the mouse dorsal vagal complex and its role in obesity

Effect of captopril on post-infarction remodelling visualized by light sheet microscopy and echocardiography

Activation of thyroid hormone receptor-β improved disease activity and metabolism independent of body weight in a mouse model of non-alcoholic steatohepatitis and fibrosis

Interferon lambda 4 genotype and pathway in alcoholic hepatitis

Whole-brain activation signatures of weight-lowering drugs

Deep learning reveals 3D atherosclerotic plaque distribution and composition

Transcriptomic changes in pancreatic islets, adipose and liver after Roux-en-Y gastric bypass in a diet-induced obese rat model

An aldehyde responsive, cleavable linker for glucose responsive insulins

Characterization of local gut microbiome and intestinal transcriptome responses to rosiglitazone treatment in db/db mice

3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II

Gut mucosal gene expression and metabolic changes after Roux-en-Y gastric bypass surgery

Identification and metabolic profiling of a novel human gut-derived LEAP2 fragment

An optimized mouse brain atlas for automated mapping and quantification of neuronal activity using iDISCO+ and light sheet fluorescence microscopy

Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy

Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative

Low interleukin-22 binding protein is associated with high mortality in alcoholic hepatitis and modulates interleukin-22 receptor expression

Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

The selective peroxisome proliferator‐activated receptor gamma modulator CHS‐131 improves liver histopathology and metabolism in a mouse model of obesity and nonalcoholic steatohepatitis

Automated image analyses of glomerular hypertrophy in a mouse model of diabetic nephropathy

Whole-brain 3D imaging for quantification of drug targets and treatment effects in mouse models of neurodegenerative diseases

Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis

Activation of adenosine monophosphate-activated protein kinase reduces the onset of diet-induced hepatocellular carcinoma in mice

Rodent models of diabetic kidney disease: human translatability and preclinical validity

Incretin combination therapy for the treatment of non-alcoholic steatohepatitis

Glucagon resistance at the level of amino acid turnover in obese subjects with hepatic steatosis

Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis

Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH

Impact of sex on diabetic nephropathy and the renal transcriptome in UNx db/db C57BLKS mice

Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease

The dorsomedial hypothalamus and nucleus of the solitary tract as key regulators in a rat model of chronic obesity

Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss

Metabolic and gut microbiome changes following GLP-1 or dual GLP-1/GLP-2 receptor agonist treatment in diet-induced obese mice

Mastiha (Pistacia Lentiscus) improves gut microbiota diversity, hepatic steatosis and disease activity in a biopsy-confirmed mouse model of advanced non-alcoholic steatohepatitis and fibrosis

Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source

Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion

Half-Life extending modifications of peptide YY3-36 direct receptor-mediated internalization

Investigating intestinal glucagon after Roux-en-Y gastric bypass surgery

RhoA in tyrosine hydroxylase neurons regulates food intake and body weight via altered sensitivity to peripheral hormones

Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH

The preprohormone expression profile of enteroendocrine cells following Roux-en-Y gastric bypass in rats

Hepatic molecular characteristics of patients with varying degrees of nonalcoholic steatohepatitis compared to healthy normal weight individuals

Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes

Animal models of type 2 diabetes, obesity and nonalcoholic steatohepatitis – clinical translatability and applicability in preclinical drug development

The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

Bariatric surgery in patients with non-alcoholic fatty liver disease - from pathophysiology to clinical effects

Pancreatic β-cell rest replenishes insulin secretory capacity and attenuates diabetes in an extreme model of obese type 2 diabetes

Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice

Molecular characterization of microvesicular and macrovesicular steatosis shows widespread differences in metabolic pathways

Disease progression and pharmacological intervention in a nutrient-deficient rat model of nonalcoholic steatohepatitis

Novel GLP-1/GLP-2 co-agonists display marked effects on gut volume and improves glycemic control in mice

Chemical Strategies for Half-life Extension of Biopharmaceuticals: Lipidation and its Alternatives

Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control

INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis

Metabolic and hepatic effects of liraglutide, obeticholic acid and elafbranor in diet-induced obese mouse models of biopsy-confrmed nonalcoholic steatohepatitis

Application of the physical disector principle for quantification of dopaminergic neuronal loss in a rat 6-hydroxydopamine nigral lesion model of Parkinson’s disease

GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

In-vitro and in-vivo studies supporting the therapeutic potential of ZP3022 in diabetes

Mouse models of nonalcoholic steatohepatitis in preclinical drug development

Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues