Mode of action studies

Mode of action studies Hyperinsulinaemic euglycaemic clamp Glucose infusion rate during hyperinsulinaemic euglycaemic clamp in lean and male Gubra DIO rats. Data demonstrates a reduced insulin sensivity in Gubra DIO rats compared to lean animals, and improved insulin...

Chronic efficacy studies

Chronic efficacy studies Longterm effects on glucose homeostasis in ZDF rats Data demonstrating the efficacy of 8 weeks chronic treatment with the DPP-4i (linagliptin), SGLT-2i (dapagliflozin), GLP-1 (liraglutide) and SUR (glibenclamide) on OGTT insulin and glucose...