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Peptide chemistry

Peptide chemistry is the foundation of Gubra drug discovery by delivering peptide drug design, peptide synthesis and purification, as well as stability, solubility and formulations. State-of-the-art solid-phase peptide methodologies enables us to synthesize peptides in high yield and purity.

As result of many years of synthesis experience we master a wide variety of chemistries such as unnatural modifications, back-bone modifications, cyclic peptides, half-life extension methodologies and beyond.

We offer:

 

  • Rational peptide drug design
  • Fmoc based solid-phase peptide synthesis (SPPS)
  • Microwave assisted solid-phase peptide synthesis (MW-SPPS)
  • High-throughput to medium-scale synthesis (up to 20 mmol/g)
  • Fully orthogonal chemistries for side-chain modifications
  • Cyclic peptides by head to tail connection or lactam bridges (stapled peptides)
  • Intra- and interchain disulfide bridge formation
  • Plasma half-life extension via by the most advanced methodologies
  • RP-HPLC purification
  • Physical stability studies by Thioflavin T (ThT) spectroscopic and dynamic light scattering
  • Heat accelerated chemical stability assessed by UPLC or LC-MS
  • Solubility techniques such as turbidimetry and dynamic light scattering

“Gubra’s scientific competence is outstanding and on par with any academic groups I have worked with”

Dr. Thomas Klein
Senior Principle Scientist | Boehringer Ingelheim

NASH review

Review of preclinical models of NASH discussing the advantages and limitations of current in vivo mouse models used in drug discovery for NASH.
Read more  |  See other publications 

Press Release

Find out more about the partner program between Boeringer Ingelheim Pharma and Gubra

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Gubra

Hørsholm Kongevej 11B
2970 Hørsholm
Denmark

info@gubra.dk
+45 3152 ­2650