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Peptide chemistry is the foundation of Gubra drug discovery by delivering peptide drug design, peptide synthesis and purification, as well as stability, solubility and formulations. State-of-the-art solid-phase peptide methodologies enables us to synthesize peptides in high yield and purity.
As result of many years of synthesis experience we master a wide variety of chemistries such as unnatural modifications, back-bone modifications, cyclic peptides, half-life extension methodologies and beyond.
- Rational peptide drug design
- Fmoc based solid-phase peptide synthesis (SPPS)
- Microwave assisted solid-phase peptide synthesis (MW-SPPS)
- High-throughput to medium-scale synthesis (up to 20 mmol/g)
- Fully orthogonal chemistries for side-chain modifications
- Cyclic peptides by head to tail connection or lactam bridges (stapled peptides)
- Intra- and interchain disulfide bridge formation
- Plasma half-life extension via by the most advanced methodologies
- RP-HPLC purification
- Physical stability studies by Thioflavin T (ThT) spectroscopic and dynamic light scattering
- Heat accelerated chemical stability assessed by UPLC or LC-MS
- Solubility techniques such as turbidimetry and dynamic light scattering
“Gubra’s scientific competence is outstanding and on par with any academic groups I have worked with”
Dr. Thomas Klein
Senior Principle Scientist | Boehringer Ingelheim
Find out more about the partner program between Boeringer Ingelheim Pharma and Gubra
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