Imaging

New technologies such as light sheet microscopy and whole organ immunohistochemistry are revolutionizing our understanding of disease progression and drug distribution.  As one of the first CRO’s in the world, Gubra has implemented these novel technologies into our existing pre-clinical platform, and now offers 3D imaging of intact organs with single cell resolution.

3D imaging is particularly useful when studying complex structures such as the vasculature or neuronal innervation. By injecting fluorescently labelled molecules, such as peptides or antibodies, you can also use the technology to visualize distribution throughout the body and in particular how they access the CNS.

We offer:

• Whole organ imaging (light sheet microscopy)
• In vivo distribution of peptides and antibodies
• Whole organ immunohistochemistry (iDISCO)
• 3D Receptor mapping
• Quantitative image analysis

Normal liver stained for aSMA and CK7

NASH liver stained for a SMA and CK7