Customized services

Explore high-end models within neurodegenerative and gastrointestinal diseases.

Gastrointestinal diseases

  • Stereological assessment of total inflammatory volume
  • Multiplex cytokine measurements
  • Flow cytometry
  • Immunohistochemistry and In situ hybridizations
  • Cyclosporine as positive control

See snippits from our gallery of whole-brain imaging videos below.

Quantitative analyses of neuron number and projections

In animal models of Parkinson’s disease estimation of dopaminergic neuron numbers and projections are imperative for model phenotyping and assessment of drug treatment effects.

Send us the brains – our 3D c-Fos imaging platform is applicable to any relevant in vivo model in the mouse.

Download our flyer: Whole-brain analysis of dopaminergic cells

Visualization and quantification of whole-brain plaque load

3D whole brain imaging can help identify more efficient drugs for Alzheimer’s disease. At Gubra we have developed a light sheet microscopy based algorithm for visualization and quantification of whole-brain plaque load in mouse models of AD.

Read publication: Whole-brain three-dimensionalimaging for quantification of drugtargets and treatment effects in mousemodels of neurodegenerative diseases

Whole-brain three-dimensional visualization and automated quantitation of tyrosine hydroxylase (TH)-positive neurons

Parkinson’s disease affects tyrosine-hydroxylase-expressing dopaminergic neurons and results in specific motor and non-motor symptoms. With high-resolution whole-brain light-sheet imaging, it is now possible to map every tyrosine-hydroxylase-expressing neuron in the mouse brain and study the underlying mechanisms of Parkinson’s disease.

Read publication: Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson’s disease


Rooted in the Gut-Brain Axis

Gubra is an abbreviation for GUt and BRAin, the original key focus areas of our research and expertise. We believe that the next great leap forward in treatment paradigms within obesity, diabetes and related metabolic disorders will be found in the interplay of the gut and the brain.

A better understanding of the gut-brain axis will reveal the aetiology of diabetes, obesity and related metabolic disorders and guide us towards novel future treatments of today’s unmed medical needs.

Specialist in the Gut and BRAin diseases

Our in-depth knowledge and experience with the GUt and BRAin have prompted several spin-off studies in structurally related disease areas. We call them our customized services.

 

Related Links

Main offerings

 

  • Parkinson’s disease – Aav-Syn mouse model, MPTP mouse model, 6-OHDA rat model, locomotor behaviour, high-end 3D imaging and stereology
  • Alzheimers’s disease – high-end 3D imaging, stereology, total plaque and tangle volume and number
  • Inflammatory bowel disease – DSS model pharmacology, Unbiased stereology, Cytokine assays, Flow Cytometry and 3D imaging
  • Crohn’s disease – TNBS-induced colitis, unbiased stereology

Get in touch

Please get in touch if you are interested in discussing how to get started with your study.

Jacob Jelsing

Co-founder, vice chairman of the board

jacob@gubra.dk
+45 3152 2652