Cro services in
Whole Brain Histology
& 3D imaging
Gubra provides innovative solutions for preclinical CNS research using quantitative whole brain histology and imaging. Whether you are working on a publication or a late-stage mode of action project, we can help characterizing a variety of CNS endpoints ranging from neuronal activity (c-Fos), blood-brain-barrier (BBB) passage to markers of neurodegeneration. Using light-sheet fluorescent microscopy (LSFM) in combination with AI-assisted image analysis and cloud-based brain browser, we deliver precise quantitative data of the entire brain directly to your desktop.
Why Gubra?
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Experts in quantitative whole brain histology and light-sheet microscopy
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Studies tailored to meet the requirements of publications or IND/NDA reports
- Quantitative data from hundreds of brain regions
- Cloud-based interactive data viewer for delivering complex data
- Well-established models for neuronal activity (c-Fos), drug distribution and gene therapy
Consult with Jacob Hecksher-Sørensen
Director, Scientific Sales
Discover how whole brain imaging can help you advance your drug development.
Imaging services that enable quantification and visualization of your drug’s effects
Gubra is changing the future of preclinical CNS drug discovery with an industry-leading 3D imaging platform. Explore how our whole-brain imaging pipeline can visualize drug distribution, map drug targets and quantify treatment outcomes in unprecedented detail.
Main Offerings
Quantitative
whole brain imaging
Anatomical
reference mapping
Automated
stereotactic surgery
Complete
pharmacological solutions
Multiplexed
IHC & ISH endpoints
Gene
& cell therapy
Complex 3D imaging data to clear interpretable data
Atlas-defined CNS imaging endpoints
Parkinson’s Disease
- Quantification of total dopaminergic neuron numbers
- Mapping and quantifying α-synuclein aggregate spreading Neuroinflammation markers
- Markers of axon architecture
- Monitoring progression of motor deficits
Alzheimer’s Disease
- Quantification of amyloid plaque burden
- Mapping cerebral amyloid angiopathy
- Visualization of drug distribution and BBB penetration
- Neuronal loss and brain atrophy
CNS activation
- Whole-brain activation (c-Fos) maps
- Voxel-based statistical maps for subanatomical responses
- Comparative c-Fos maps for benchmarking drugs
Drug distribution
- Visualization and mapping of CNS drug distribution
- Parenchyma vs vascular drug distribution
- Mapping and quantifying BBB penetrance
Gene therapy
- Distribution of AAV and non-viral gene delivery systems
- Visualization of siRNA distribution
- Validation and quantification of target knockdown/overexpression
Gene expression
- Whole-brain in situ hybridization for gene expression maps
- Quantification of drug target expression at single-nuclei resolution
- Delineating gene expression changes in disease models
Related pages
For further information
Contact us
Gubra
Hørsholm Kongevej 11B
2970 Hørsholm
Denmark
+45 3152 2650