Services within 3D imaging
Quantitative 3D imaging using light sheet fluorescent microscopy is currently revolutionizing
the way we look at pre-clinical endpoints and biodistribution
Publications
Posters
Publications
Get in touch
Please get in touch if you are interested in discussing how to get started with your study. Reach out to Director Jacob Hecksher-Søresensen jhs@gubra.dk Ph. +45 2986 9407

A mouse brain atlas for virtual neuroscience
NeuroPedia is our vision of neuroscience in the future. It is an open source database for digital whole-brain maps recorded using light-sheet microscopy. The underlying principle is that all maps registered to the same reference brain are compatible. This will allow researchers to share and compare data from different experiments or overlay gene expression data with neuronal activity or connectivity – virtually!

3D imaging publications
Quantitative Gubra 3D imaging studies across various organs.
CNS
- Whole-brain activation signatures of weight-lowering drugs
- Whole-brain mapping of amylin-induced neuronal activity in receptor activity–modifying protein (RAMP) 1/3 knockout mice
- Comparative study of voxel-based statistical analysis methods for fluorescently labelled and light sheet imaged whole-brain samples
- An optimized mouse brain atlas for automated mapping and quantification of neuronal activity using iDISCO+ and light sheet fluorescence microscopy
- Whole-brain three-dimensional imaging for quantification of drug targets and treatment effects in mouse models of neurodegenerative diseases
- Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson’s disease
Pancreas
Cardiovascular system
Gubra 3D Experience
To enable fast and efficient data mining of quantitative 3D imaging data, Gubra has developed a web-based 3D imaging data viewer (Gubra 3D Experience, G3DE). This resource provides researchers with a platform for exploring Gubra’s published 3D imaging data in further detail.
Click here to explore individual brain regions of interest, display quantitative c-Fos data and filter for regions with statistically significant response to drug treatment.
Gubra imaging approach
Gubra is a world leader in whole organ imaging and AI-assisted quantification. We strongly believe that this approach is the future in pre-clinical drug discovery.
Quantitative 3D light sheet microscopy can be applied to all organs in mouse and rat. It can be used in combination with immunolabelling or in vivo distribution of fluorescently labelled molecules.
Our imaging platform is integrated into Gubra’s pipeline and works seamlessly in combination with our animal models to ensure absolute quantification of disease endpoints
Related Links:
Main offerings
- Quantitative whole brain imaging
- Neuronal activation (drug induced or physiological)
- Whole organ quantification of Islet counts and beta cell volume in model of T1 and T2 diabetes
- Glomeruli count and volumetric analysis in models of kidney disease
- Vascular remodelling in heart, eyes and adipose tissue
- Drug distribution (all organs)
- Customized endpoints – any specific endpoint you have in mind
Get in touch
Please get in touch if you are interested in discussing how to get your study started.

Jacob Hecksher-Søresensen
Director
jhs@gubra.dk
+45 2986 9407