Cro services in
Heart (CVD)
Gubra offers a unique combination of in vivo and ex vivo methodologies to evaluate drug efficacy on cardiovascular endpoints. Advance your drug pipeline using Gubra’s advanced preclinical CRO services within cardiovascular diseases.
Why Gubra?
- Hypertension models with non-invasive blood pressure monitoring
- High-throughput models of atherosclerosis
- Advanced 3D imaging for atherosclerotic plaque quantification
- Heart failure models with cardiac fibrosis
- Extensive experience within echocardiography
Consult with Michael Christensen
Principal Scientist, Scientific Sales
Accelerate your drug development with clinical endpoints applied to heart disease models.
Advanced 3D imaging for assessment of clinically relevant endpoints
We offer sophisticated models of atherosclerosis and apply our world leading 3D imaging platform to analyze plaque formation and bring high-resolution data. For Heart failure models we deliver extensive assessment of cardiac function via echocardiography analysis and image analysis of cardiac fibrosis.
Main Offerings
High resolution
echocardiography
Quantitative
fibrosis scoring
Quantitative
whole heart imaging
Quantitative
plaque lesion imaging
Assessment of
plasma markers
Explore cardioprotective drug candidates with Gubra
Cardiovascular disease (CVD) models
AngII mouse
- Hypertension induced heart failure
- Infusion with angiotensin II in lean mice
- Systolic dysfunction including reduced ejection fraction
- Extensive perivascular/interstitial myocardial fibrosis
DIO-LDLR-KO mouse
- Atherosclerosis mouse model
- Male LDLR-/- mice on western diet
- Dyslipidemia with hypercholesterolemia (LDL)
- Quantitative 3D imaging of plaque formation
- Quantitative 3D imaging of vascular inflammation
DIO-PCSK9-AAV mouse
- Atherosclerosis mouse model
- PCSK9-AAV in combination with WD
- Dyslipidemia/hypercholesterolemia in mice
- Quantitative 3D imaging of plaque formation
- Quantitative 3D imaging of vascular inflammation
Related pages
For further information
Contact us
Gubra
Hørsholm Kongevej 11B
2970 Hørsholm
Denmark
+45 3152 2650