Histology and Stereology
Improve the quality of your study endpoints
We offer complete histology solutions on any tissue from animal to man.
Solutions are custommade to your specific needs using tissue from your internal experiments or tissue from in vivo studies performed at Gubra.
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Main technological offerings
Immunohistochemistry
In situ hybridisation
Histochemical stains
- Hematoxylin Eosin (H&E)
- Picrosirius red (PSR)
- Periodic Acid-Schiff (PAS)
- and more
Histopathology
• Discuss endpoint with our team of histopathologist.
Image Analyses
Laser Capture Microdissection (LCM)
• Gene expression analyses in specific cells or groups of cells.
Stereology
• Beta cell mass
• Gut volume and cell numbers
• Neuron count
• Glomeruli numbers
• newCAST
Neurodegenerative diseases
– a customized service
With a strong academic background in neuroscience and neurostereology we have condected several preclinical studies of neurodegenerative diseases, including Parkinson and Alzheimers Disease.
Histological Analyses
Pancreas: Stereological assessment of beta cell mass
Gubra has ample experienced with histological and stereological assessment of basically any component of the pancreas, from endocrine to exocrine features. A in-housed develop sampling method (see video) provides the basis for all our investigations.
Kidney: AI assisted quantification of glomerulosclerosis
At Gubra, we have developed AI-assisted detection of glomeruli in Periodic Schiff-acid stained sections for subsequent quantification of glomerulosclerosis. Histopathological scoring can be performed to assist the quantitative output.
Gut: The effect of bariatric surgery on gut morphology
We have investigated an enormous plasticity of the gut in mice, rats, pigs and humans and shown adaptations to obesity and different gastric bypass surgeries.
Biopsy-confirmed NASH with Fibrosis
The Gubra biopsy-confirmed DIO NASH model with fibrosis has become the preferred preclinical standard for assessments of drug induced changes. Check out our advanced histological endpoints.
Laser Capture Microdissection
See our movie about how Laser capture microdissection (LCM) enables you to fish out specific cells from heterogeneous organs and gives you a level of precision not possible with manual extraction methods.
An introduction to stereology
Stereology is a practical technique for extracting quantitative information about a 3D structure from measurements made on 2D histological section. It produces results that are unbiased, efficient, and more reliable than other ad hoc quantitative analyses
