Histology and Stereology

Improve the quality of your study endpoints

We offer complete histology solutions on any tissue from animal to man.

Solutions are custommade to your specific needs using tissue from your internal experiments or tissue from in vivo studies performed at Gubra.

 

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Main technological offerings

Immunohistochemistry

• Single IHC

• Double IHC

• Triple IHC

• Chromagen or fluorescent based

See videos and flyers below

In situ hybridisation

• Single ISH

• Double ISH

• Triple ISH

• Chromagen or fluorescent based

See videos and flyers below

Histochemical stains
  • Hematoxylin Eosin (H&E)
  • Picrosirius red (PSR)
  • Periodic Acid-Schiff (PAS)
  • and more

See videos and flyers below

Histopathology

• Discuss endpoint with our team of histopathologist.

See videos and flyers below

Image Analyses

• AI Image Analysis

• Visiomorph

See videos and flyers below

Laser Capture Microdissection (LCM)

• Gene expression analyses in specific cells or groups of cells.

See videos and flyers below

Stereology

• Beta cell mass

• Gut volume and cell numbers

• Neuron count

• Glomeruli numbers

• newCAST

See videos and flyers below

Neurodegenerative diseases
– a customized service

With a strong academic background in neuroscience and neurostereology we have condected several preclinical studies of neurodegenerative diseases, including Parkinson and Alzheimers Disease.

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Histological Analyses

Pancreas: Stereological assessment of beta cell mass

Gubra has ample experienced with histological and stereological assessment of basically any component of the pancreas, from endocrine to exocrine features. A in-housed develop sampling method (see video) provides the basis for all our investigations.

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Kidney: AI assisted quantification of glomerulosclerosis

At Gubra, we have developed AI-assisted detection of glomeruli in Periodic Schiff-acid stained sections for subsequent quantification of glomerulosclerosis. Histopathological scoring can be performed to assist the quantitative output.

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Gut: The effect of bariatric surgery on gut morphology

We have investigated an enormous plasticity of the gut in mice, rats, pigs and humans and shown adaptations to obesity and different gastric bypass surgeries.

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Biopsy-confirmed NASH with Fibrosis

The Gubra biopsy-confirmed DIO NASH model with fibrosis has become the preferred preclinical standard for assessments of drug induced changes. Check out our advanced histological endpoints.

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Laser Capture Microdissection

See our movie about how Laser capture microdissection (LCM) enables you to fish out specific cells from heterogeneous organs and gives you a level of precision not possible with manual extraction methods.

An introduction to stereology

Stereology is a practical technique for extracting quantitative information about a 3D structure from measurements made on 2D histological section. It produces results that are unbiased, efficient, and more reliable than other ad hoc quantitative analyses

"Gubra is easy to work with – less paperwork, valuable scientific input, flexible project management as well as clear and proactive communication."

Jim Trevaskis
Director | In Vivo Pharmacology | Gilead

“When it comes to working with Gubra, I highly appreciate the strong scientific involvement and curiosity that permeates our collaborations. I cannot ask for a stronger partner in our human physiology and clinical research projects.”

Filip Knop
MD, PhD, Director of Center for Diabetes Research | Gentofte Hospital, University of Copenhagen

“The long term experience and the deep scientific competence of Gubra partners adds value to the studies and is a guaranty for trustworthy results.“

Dr. Michael Mark
Vice President | Boeringer Ingelheim

Get in touch

Get in touch if you are interested in discussing how to get started with your study.

Jacob Jelsing

Co-founder

jacob@gubra.dk
+45 2382 9493