Gubra video gallery

Gubra video gallery

Here is a collection of all of our favorite 3D imaging and stereology videos.

TH neuron in an adult mouse brain

High resolution light-sheet microscopy of dopaminergic neurons in an adult mouse brain. The sample was stained with antibodies against Tyrosine hydroxylase (glow scale) to label TH neurons in the substantia nigra (SN) and ventral tegmental area (VTA).

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Functional kidney imaging

High resolution light-sheet microscopy of albumin reuptake in the proximal tubules in a wild-type adult kidney. The sample was labelled in vivo with fluorescent albumin (glow scale) and fluorescent lectin (blue) for labelling of the glomeruli.

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Pancreas imaging

Light-sheet microscopy of an adult pancreas from a wild-type mouse. The sample was stained with antibodies against insulin (glow scale), aSMA (green) to label the vasculature and TH to label the sympathetic nervous system (yellow).

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In vivo distribution of GLP-1R agonist

Light-sheet microscopy of fluorescently labelled GLP-1 (magenta) in the pancreas from an adult wild-type mouse.

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Vascular imaging

Light-sheet microscopy of Evans Blue (magenta) in the brain from an adult wild-type mouse.

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In vivo distribution of GLP-1R agonist

Light-sheet microscopy of fluorescently labelled GLP-1 (glow scale) in the brain from an adult wild-type mouse.

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Neuronal activation in an adult mouse brain

Light-sheet microscopy of activated neurons in an adult mouse brain. After treatment with liraglutide the sample was stained with antibodies against c-Fos (glow scale) to visualise activated neurons in the whole brain.

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Plaques in an adult mouse brain

Light-sheet microscopy of plaques in the brain from an APP/PS1 adult mouse. To visualise plaques the brain was stained with Congo Red (glow scale).

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Inflammation in adipose tissue

Light-sheet microscopy of white adipose tissue from an obese mouse. The sample was stained with antibodies against CD45 (yellow) to label inflammatory cells and SM22 (cyan) to visualize the vasculature.

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Kidney imaging

Light-sheet microscopy of glomeruli and vasculature in an adult kidney from a wild-type mouse. The sample was stained with antibodies against Podocin1 (red) to label glomeruli and aSMA (green) to label the vasculature.

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Retinal vasculature (white)

Light-sheet imaging of the retinal vasculature (white) in the eye from a wild-type adult mouse. The capillaries were labelled in vivo using tomato lectin.

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Healthy liver from an adult mouse

Light-sheet imaging of a healthy liver from an adult mouse stained with antibodies against CK7 (green) to label the bile ducts and alpha-Smooth muscle actin (red) to label the vasculature.

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Imaging of neuronal subtypes

Light-sheet microscopy of an adult brain from a wild-type mouse. The sample was stained with antibodies against Orexin (glow scale) to label the orexin neurons in the hypothalamus.

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Whole brain visualisation of AAV expression

Light-sheet microscopy of a whole adult mouse brain injected with AAV virus (glow scale). Courtesy of Georges Mairet-Coello, UCB.

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Whole brain biodistribution

Light-sheet microscopy of antisense oligonucleotide distribution in the adult mouse brain (glow scale).

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Whole heart imaging of fibrosis

3D light-sheet microscopy of tenascin C labelling in a mouse model of hypertensive heart disease. Courtesy of Qing-Dong Wang, AstraZeneca.

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